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F8AVM7 (F8AVM7_FRADG) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:FsymDg_3700 EMBL AEH10977.1
OrganismFrankia symbiont subsp. Datisca glomerata [Complete proteome] [HAMAP] EMBL AEH10977.1
Taxonomic identifier656024 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Frankineae › Frankiaceae › Frankia

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS000291

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS000291

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS000291.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS000291

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain168 – 375208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding196 – 25055ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3291Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3421Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3421Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3441Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8AVM7 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: F8A2F8921914D4D7

FASTA38539,480
        10         20         30         40         50         60 
MPGSPPRRTR IAVLYGGRST EHAISCVSAG SVLRALDRRR YDVVAVGITP DGRWVLGPDD 

        70         80         90        100        110        120 
PDALAVRDGV LPAVDATARP VVLPGDPTVG GLIALDGVAV SAGPGPADRG TADLGAVGLG 

       130        140        150        160        170        180 
AVDVVFPLLH GPFGEDGTVQ GLLEMAAVPY VGSGVFASAA AMDKQYMKIL LAAAGLDIGP 

       190        200        210        220        230        240 
YTVLRAGQAL SGDDRERLGL PVFVKPARGG SSIGISRVDA WDDLATALKA ARAVDPKVLV 

       250        260        270        280        290        300 
EAAVVGREVE CGVLGSLDGG GPEASLPAEV TVASSAGSAG FYDFEAKYLS DAARFDVPAN 

       310        320        330        340        350        360 
LPAEVTAAVR QIAVRAFVAL DCAGLARVDV FVRPDGSVVV NEVNTMPGFT PTSMFPRMWA 

       370        380 
ATGLDYPRLV DRLVALATRH GTGLH

« Hide

References

[1]"Complete sequence of chromosome of Frankia symbiont of Datisca glomerata."
US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Chertkov O., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Berry A. expand/collapse author list , Pawlowski K., Persson T., Vanden Heuvel B., Benson D., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 4085684 EMBL AEH10977.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002801 Genomic DNA. Translation: AEH10977.1.
RefSeqYP_004584898.1. NC_015656.1.

3D structure databases

ProteinModelPortalF8AVM7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH10977; AEH10977; FsymDg_3700.
GeneID10784385.
KEGGfsy:FsymDg_3700.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMALLHGPFG.

Enzyme and pathway databases

BioCycFSYM656024:GHLT-3728-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8AVM7_FRADG
AccessionPrimary (citable) accession number: F8AVM7
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 29, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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