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Protein

Alanine racemase

Gene

FsymDg_3922

Organism
Frankia symbiont subsp. Datisca glomerata
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (FsymDg_3922)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei272 – 2721Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciFSYM656024:GHLT-3953-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:FsymDg_3922Imported
OrganismiFrankia symbiont subsp. Datisca glomerataImported
Taxonomic identifieri656024 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaFrankialesFrankiaceaeFrankia
ProteomesiUP000001549 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi656024.FsymDg_3922.

Structurei

3D structure databases

ProteinModelPortaliF8AUZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiITMDQLM.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8AUZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTQSEGLRA CAIVDLDAVR ASVATLVARA GNAATMAVVK SDGYGHGMSA
60 70 80 90 100
CARAAVEAGA SWLGVAVIEE GLALRAAGFT VPVFAWLTAP GEPLADALAA
110 120 130 140 150
DIDLSASAPW MLAEIAAAAR HTGRRARVHL KADTGLGRGG ATEADWPSLC
160 170 180 190 200
DAAAALAAED LIEVTGVWSH LAFADSPGHP TVRGQIGRFA DAVTIAEKTG
210 220 230 240 250
LRPQVRHLAN SAATLVSPDA RFDMVRPGIS VYGLSPGPQV GSPAALGLRP
260 270 280 290 300
AMTLTARLAL AKRVPAGSGV SYAHRYTTAV ASTLGLVPLG YADGVPRAAG
310 320 330 340 350
NTAEVLLAGR RRRIAGTVCM DQFVVDVGDD PVQAGDQVIL FGSGEHGEPT
360 370 380 390 400
AQDWADALGT INYEIVTRVG VRVPRVHLNA SDGPRGTGRQ APGGPGAARP
410 420 430 440
APGMAGSAPA AVGPSDAGLS GAGSSGPGLP GAGPSAPGWL PS
Length:442
Mass (Da):44,366
Last modified:September 21, 2011 - v1
Checksum:i2919D5013DA8C90F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002801 Genomic DNA. Translation: AEH11197.1.
RefSeqiWP_013875075.1. NC_015656.1.
YP_004585118.1. NC_015656.1.

Genome annotation databases

EnsemblBacteriaiAEH11197; AEH11197; FsymDg_3922.
KEGGifsy:FsymDg_3922.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002801 Genomic DNA. Translation: AEH11197.1.
RefSeqiWP_013875075.1. NC_015656.1.
YP_004585118.1. NC_015656.1.

3D structure databases

ProteinModelPortaliF8AUZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi656024.FsymDg_3922.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH11197; AEH11197; FsymDg_3922.
KEGGifsy:FsymDg_3922.

Phylogenomic databases

KOiK01775.
OMAiITMDQLM.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciFSYM656024:GHLT-3953-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Frankia symbiont of Datisca glomerata."
    US DOE Joint Genome Institute
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Chertkov O., Teshima H., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Berry A.
    , Pawlowski K., Persson T., Vanden Heuvel B., Benson D., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 4085684Imported.

Entry informationi

Entry nameiF8AUZ4_FRADG
AccessioniPrimary (citable) accession number: F8AUZ4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.