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F8AM17

- F8AM17_METOI

UniProt

F8AM17 - F8AM17_METOI

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Protein
Ribulose bisphosphate carboxylase
Gene
rbcL, Metok_0719
Organism
Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531Proton acceptor By similarityUniRule annotation
Binding sitei155 – 1551Substrate By similarityUniRule annotation
Metal bindingi179 – 1791Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Metal bindingi182 – 1821Magnesium By similarityUniRule annotation
Active sitei269 – 2691Proton acceptor By similarityUniRule annotation
Binding sitei270 – 2701Substrate By similarityUniRule annotation
Binding sitei302 – 3021Substrate By similarityUniRule annotation
Sitei309 – 3091Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMOKI647113:GHB9-744-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:Metok_0719Imported
OrganismiMethanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)Imported
Taxonomic identifieri647113 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus
ProteomesiUP000009296: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8AM17.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni353 – 3553Substrate binding By similarityUniRule annotation
Regioni375 – 3784Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

F8AM17-1 [UniParc]FASTAAdd to Basket

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MDYLELGYEP KDNELLSCMV VKAENLKKAA NDIAGESSIG TWTELKTMKS    50
EIYKKLKPRV YEINEMGKEG DTNIGLIKIA YPLDTFEPNN MPGTLAGIAG 100
NIFGMKSLNG LRILDFRFPK EFIKCYSGPK YGIKGIRKLL NVMERPLVGT 150
IVKPKVGLNS EEHAKVAYNS WIGGCDIVKD DENLVSQDFN KFEGRLHKVL 200
ECRDKAESET GEKKIYMPNI TAPYREMVRR AELVEDAGCE YAMIDVVVLG 250
FSAVQQIREE GFNFAIHAHR AMHAAITRSR EWGISMLALA KIYRLLGVDQ 300
LHIGTVVGKM EGGKDEVCSI RDEIVLEDVK EDNKNKFFNQ KWHGLNNTFP 350
VSSGGVYPKL VPEIVNIFGK DVIIQAGGGI HGHPEGTVAG ARAMRASVEA 400
SIEGIPLSEK AEEVSELKKA LEYWK 425
Length:425
Mass (Da):47,362
Last modified:September 21, 2011 - v1
Checksum:iE2A1A4B6BF3F5829
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002792 Genomic DNA. Translation: AEH06696.1.
RefSeqiWP_013866882.1. NC_015636.1.
YP_004576474.1. NC_015636.1.

Genome annotation databases

EnsemblBacteriaiAEH06696; AEH06696; Metok_0719.
GeneIDi10772860.
KEGGimok:Metok_0719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002792 Genomic DNA. Translation: AEH06696.1 .
RefSeqi WP_013866882.1. NC_015636.1.
YP_004576474.1. NC_015636.1.

3D structure databases

ProteinModelPortali F8AM17.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH06696 ; AEH06696 ; Metok_0719 .
GeneIDi 10772860.
KEGGi mok:Metok_0719.

Phylogenomic databases

KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci MOKI647113:GHB9-744-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methanothermococcus okinawensis IH1."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sieprawska-Lupa M., Takai K.
    , Miyazaki J., Whitman W., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14208 / JCM 11175 / IH1.

Entry informationi

Entry nameiF8AM17_METOI
AccessioniPrimary (citable) accession number: F8AM17
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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