Skip Header

Contribute Send feedback
Read comments (?) or add your own

F8AK58 (F8AK58_METOI) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine synthase 1 HAMAP-Rule MF_00421
EC=6.3.5.3 HAMAP-Rule MF_00421
Alternative name(s):
Phosphoribosylformylglycinamidine synthase I HAMAP-Rule MF_00421
Gene names
Name:purQ HAMAP-Rule MF_00421
Ordered Locus Names:Metok_1462 EMBL AEH07425.1
OrganismMethanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1) [Complete proteome] [HAMAP] EMBL AEH07425.1
Taxonomic identifier647113 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanococci › Methanococcales › Methanococcaceae › Methanothermococcus ›

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H2O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate. HAMAP-Rule MF_00421

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2. HAMAP-Rule MF_00421

Subunit structure

Heterodimer of two subunits, PurQ and PurL By similarity. HAMAP-Rule MF_00421

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00421.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_00421

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain2 – 226225Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_00421

Sites

Active site851Nucleophile By similarity HAMAP-Rule MF_00421
Active site2021 By similarity HAMAP-Rule MF_00421
Active site2041 By similarity HAMAP-Rule MF_00421

Sequences

Sequence LengthMass (Da)Tools
F8AK58 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 3FBA6AAC56E07817

FASTA22624,970
        10         20         30         40         50         60 
MDIAVIKFLG TNCDKDVCHT VKLAGGKPEL VWFSETDLSR FNGAVIPGGF SYGDYLRAGA 

        70         80         90        100        110        120 
ISSKTPVING LKKMIDDGKP VLGICNGAQI GLEAGFSYGT LTNNINARFI CKWVYIRVEN 

       130        140        150        160        170        180 
NNTPFTKYYK KGEVLKIPIA HAEGRFYTDE DTLQEMYKKN MVVFKYCDEN GEVTDEVNPN 

       190        200        210        220 
GSIDNIAGVC NENKNCVLLM PHPERASEKI LGSDDGLNMF KAMISK

« Hide

References

[1]"Complete sequence of chromosome of Methanothermococcus okinawensis IH1."
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sieprawska-Lupa M., Takai K. expand/collapse author list , Miyazaki J., Whitman W., Woyke T.
Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 14208 / JCM 11175 / IH1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002792 Genomic DNA. Translation: AEH07425.1.
RefSeqYP_004577203.1. NC_015636.1.

3D structure databases

ProteinModelPortalF8AK58.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH07425; AEH07425; Metok_1462.
GeneID10773620.
KEGGmok:Metok_1462.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01952.
OMAFPGTNCD.

Enzyme and pathway databases

BioCycMOKI647113:GHB9-1504-MONOMER.
UniPathwayUPA00074; UER00128.

Family and domain databases

HAMAPMF_00421. PurQ.
InterProIPR017926. GATASE_1.
IPR010075. PRibForGlyAmidine_synth_I.
[Graphical view]
PIRSFPIRSF001586. FGAM_synth_I. 1 hit.
TIGRFAMsTIGR01737. FGAM_synth_I. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8AK58_METOI
AccessionPrimary (citable) accession number: F8AK58
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info