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F8AJL1

- HPRT_METOI

UniProt

F8AJL1 - HPRT_METOI

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Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene
hpt, Metok_1229
Organism
Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMOKI647113:GHB9-1270-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:Metok_1229
OrganismiMethanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)
Taxonomic identifieri647113 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus
ProteomesiUP000009296: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotationPRO_0000415485Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8AJL1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8AJL1-1 [UniParc]FASTAAdd to Basket

« Hide

MNLLEDTLKS CPIVKRGEYN YFIHPITDGV PLMNSQLLRE VATKIIKISD    50
MDIDKIVTAE AMGIPIATTI SLYTDIPYVI MRKRKYLLEG EIPVHQETGY 100
SKGELYLNGV NKGDKVLIVD DVISTGGTMV AIIKALEKAG AHIKDIVCVI 150
ERGNGKEEVK EKTGYDVKTL VKIDVVNGKV VIL 183
Length:183
Mass (Da):20,232
Last modified:September 21, 2011 - v1
Checksum:i215A03625F8F8596
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002792 Genomic DNA. Translation: AEH07197.1.
RefSeqiWP_013867380.1. NC_015636.1.
YP_004576975.1. NC_015636.1.

Genome annotation databases

EnsemblBacteriaiAEH07197; AEH07197; Metok_1229.
GeneIDi10773385.
KEGGimok:Metok_1229.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002792 Genomic DNA. Translation: AEH07197.1 .
RefSeqi WP_013867380.1. NC_015636.1.
YP_004576975.1. NC_015636.1.

3D structure databases

ProteinModelPortali F8AJL1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH07197 ; AEH07197 ; Metok_1229 .
GeneIDi 10773385.
KEGGi mok:Metok_1229.

Phylogenomic databases

KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MOKI647113:GHB9-1270-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Methanothermococcus okinawensis IH1."
    Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sieprawska-Lupa M., Takai K.
    , Miyazaki J., Whitman W., Woyke T.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 14208 / JCM 11175 / IH1.

Entry informationi

Entry nameiHPRT_METOI
AccessioniPrimary (citable) accession number: F8AJL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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