Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F8AJL1

- HPRT_METOI

UniProt

F8AJL1 - HPRT_METOI

Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciMOKI647113:GHB9-1270-MONOMER.
    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
    Short name:
    HGPRTaseUniRule annotation
    Gene namesi
    Name:hptUniRule annotation
    Ordered Locus Names:Metok_1229
    OrganismiMethanothermococcus okinawensis (strain DSM 14208 / JCM 11175 / IH1)
    Taxonomic identifieri647113 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanothermococcus
    ProteomesiUP000009296: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415485Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF8AJL1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

    Phylogenomic databases

    KOiK00759.
    OMAiIATDIPY.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01467. Hypx_phosphoribosyltr.
    InterProiIPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8AJL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLLEDTLKS CPIVKRGEYN YFIHPITDGV PLMNSQLLRE VATKIIKISD    50
    MDIDKIVTAE AMGIPIATTI SLYTDIPYVI MRKRKYLLEG EIPVHQETGY 100
    SKGELYLNGV NKGDKVLIVD DVISTGGTMV AIIKALEKAG AHIKDIVCVI 150
    ERGNGKEEVK EKTGYDVKTL VKIDVVNGKV VIL 183
    Length:183
    Mass (Da):20,232
    Last modified:September 21, 2011 - v1
    Checksum:i215A03625F8F8596
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002792 Genomic DNA. Translation: AEH07197.1.
    RefSeqiWP_013867380.1. NC_015636.1.
    YP_004576975.1. NC_015636.1.

    Genome annotation databases

    EnsemblBacteriaiAEH07197; AEH07197; Metok_1229.
    GeneIDi10773385.
    KEGGimok:Metok_1229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002792 Genomic DNA. Translation: AEH07197.1 .
    RefSeqi WP_013867380.1. NC_015636.1.
    YP_004576975.1. NC_015636.1.

    3D structure databases

    ProteinModelPortali F8AJL1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH07197 ; AEH07197 ; Metok_1229 .
    GeneIDi 10773385.
    KEGGi mok:Metok_1229.

    Phylogenomic databases

    KOi K00759.
    OMAi IATDIPY.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .
    BioCyci MOKI647113:GHB9-1270-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01467. Hypx_phosphoribosyltr.
    InterProi IPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Methanothermococcus okinawensis IH1."
      Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Held B., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Sieprawska-Lupa M., Takai K.
      , Miyazaki J., Whitman W., Woyke T.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 14208 / JCM 11175 / IH1.

    Entry informationi

    Entry nameiHPRT_METOI
    AccessioniPrimary (citable) accession number: F8AJL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3