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F8AH01

- F8AH01_PYRYC

UniProt

F8AH01 - F8AH01_PYRYC

Protein

DNA ligase

Gene

lig

Organism
Pyrococcus yayanosii (strain CH1 / JCM 16557)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei274 – 2741ATPUniRule annotation
    Active sitei276 – 2761N6-AMP-lysine intermediateUniRule annotation
    Binding sitei281 – 2811ATPUniRule annotation
    Binding sitei296 – 2961ATPUniRule annotation
    Binding sitei326 – 3261ATPUniRule annotation
    Binding sitei366 – 3661ATPUniRule annotation
    Binding sitei441 – 4411ATPUniRule annotation
    Binding sitei447 – 4471ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPYAY529709:GHZ0-374-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:PYCH_03680Imported
    OrganismiPyrococcus yayanosii (strain CH1 / JCM 16557)Imported
    Taxonomic identifieri529709 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
    ProteomesiUP000008386: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF8AH01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F8AH01-1 [UniParc]FASTAAdd to Basket

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    MEGDGWRDIK VVRNPYFSLR IVPTVVPMRY LELAQLYQRL EKTTLKTLKT    50
    RLVADFLKKV PNDLLEIIPY LILGDVFPEW DERELGVGEK LLIRAVSMAT 100
    GVDAKEIENS VKETGDLGES VALAIKKRKQ RSFFSQPLTI KRVYDTLVKV 150
    AEISGEGSQD KKLKYLANLF MDAEPIEAKY LARTILGIMR TGVAEGILRD 200
    AIAEAFHVKV ELVERAYMLT SDFGFVTKVA KLEGNEGLAK VTIQVGKPIK 250
    PMLAQQAASI KDALLEMGGE AEFEIKYDGA RVQVHKDGDR IIVYSRRLEN 300
    VTRSIPEVVE RLKRAIKAEK AIVEGELVAV GEDGRPLPFQ YVLRRFRRKY 350
    NIEEMIEKIP LELNLFDVLY VGGKALIDEP FIERRKTLEG IIEADGWIKV 400
    AENLITKSVE EAESFYRKAL GMGHEGLMAK RLDSVYEPGN RGKKWLKIKP 450
    TMENLDLVII GAEWGEGRRA HVFGSFILGA YDPHTGEFVE VGKVGSGFTD 500
    EDLIEFTKML KRLITKEEGK RVWFEPKVVI EVTYQEIQKS PKYRSGFALR 550
    FPRYVALRDD KGPEDADTIE RIAQLYELQE RMKGKKIA 588
    Length:588
    Mass (Da):66,835
    Last modified:September 21, 2011 - v1
    Checksum:i97387297BC0BFCE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002779 Genomic DNA. Translation: AEH24059.1.
    RefSeqiYP_004623331.1. NC_015680.1.

    Genome annotation databases

    EnsemblBacteriaiAEH24059; AEH24059; PYCH_03680.
    GeneIDi10836944.
    KEGGipya:PYCH_03680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002779 Genomic DNA. Translation: AEH24059.1 .
    RefSeqi YP_004623331.1. NC_015680.1.

    3D structure databases

    ProteinModelPortali F8AH01.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH24059 ; AEH24059 ; PYCH_03680 .
    GeneIDi 10836944.
    KEGGi pya:PYCH_03680.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci PYAY529709:GHZ0-374-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the obligate piezophilic hyperthermophilic archaeon Pyrococcus yayanosii CH1."
      Jun X., Lupeng L., Minjuan X., Oger P., Fengping W., Jebbar M., Xiang X.
      J. Bacteriol. 193:4297-4298(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CH1 / JCM 16557Imported.

    Entry informationi

    Entry nameiF8AH01_PYRYC
    AccessioniPrimary (citable) accession number: F8AH01
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3