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F8AH01

- F8AH01_PYRYC

UniProt

F8AH01 - F8AH01_PYRYC

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Protein

DNA ligase

Gene

lig

Organism
Pyrococcus yayanosii (strain CH1 / JCM 16557)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei274 – 2741ATPUniRule annotation
Active sitei276 – 2761N6-AMP-lysine intermediateUniRule annotation
Binding sitei281 – 2811ATPUniRule annotation
Binding sitei296 – 2961ATPUniRule annotation
Binding sitei326 – 3261ATPUniRule annotation
Binding sitei366 – 3661ATPUniRule annotation
Binding sitei441 – 4411ATPUniRule annotation
Binding sitei447 – 4471ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPYAY529709:GHZ0-374-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PYCH_03680Imported
OrganismiPyrococcus yayanosii (strain CH1 / JCM 16557)Imported
Taxonomic identifieri529709 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000008386: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8AH01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8AH01 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGDGWRDIK VVRNPYFSLR IVPTVVPMRY LELAQLYQRL EKTTLKTLKT
60 70 80 90 100
RLVADFLKKV PNDLLEIIPY LILGDVFPEW DERELGVGEK LLIRAVSMAT
110 120 130 140 150
GVDAKEIENS VKETGDLGES VALAIKKRKQ RSFFSQPLTI KRVYDTLVKV
160 170 180 190 200
AEISGEGSQD KKLKYLANLF MDAEPIEAKY LARTILGIMR TGVAEGILRD
210 220 230 240 250
AIAEAFHVKV ELVERAYMLT SDFGFVTKVA KLEGNEGLAK VTIQVGKPIK
260 270 280 290 300
PMLAQQAASI KDALLEMGGE AEFEIKYDGA RVQVHKDGDR IIVYSRRLEN
310 320 330 340 350
VTRSIPEVVE RLKRAIKAEK AIVEGELVAV GEDGRPLPFQ YVLRRFRRKY
360 370 380 390 400
NIEEMIEKIP LELNLFDVLY VGGKALIDEP FIERRKTLEG IIEADGWIKV
410 420 430 440 450
AENLITKSVE EAESFYRKAL GMGHEGLMAK RLDSVYEPGN RGKKWLKIKP
460 470 480 490 500
TMENLDLVII GAEWGEGRRA HVFGSFILGA YDPHTGEFVE VGKVGSGFTD
510 520 530 540 550
EDLIEFTKML KRLITKEEGK RVWFEPKVVI EVTYQEIQKS PKYRSGFALR
560 570 580
FPRYVALRDD KGPEDADTIE RIAQLYELQE RMKGKKIA
Length:588
Mass (Da):66,835
Last modified:September 21, 2011 - v1
Checksum:i97387297BC0BFCE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002779 Genomic DNA. Translation: AEH24059.1.
RefSeqiYP_004623331.1. NC_015680.1.

Genome annotation databases

EnsemblBacteriaiAEH24059; AEH24059; PYCH_03680.
GeneIDi10836944.
KEGGipya:PYCH_03680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002779 Genomic DNA. Translation: AEH24059.1 .
RefSeqi YP_004623331.1. NC_015680.1.

3D structure databases

ProteinModelPortali F8AH01.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH24059 ; AEH24059 ; PYCH_03680 .
GeneIDi 10836944.
KEGGi pya:PYCH_03680.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci PYAY529709:GHZ0-374-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the obligate piezophilic hyperthermophilic archaeon Pyrococcus yayanosii CH1."
    Jun X., Lupeng L., Minjuan X., Oger P., Fengping W., Jebbar M., Xiang X.
    J. Bacteriol. 193:4297-4298(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH1 / JCM 16557Imported.

Entry informationi

Entry nameiF8AH01_PYRYC
AccessioniPrimary (citable) accession number: F8AH01
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3