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Protein

DNA ligase

Gene

lig

Organism
Pyrococcus yayanosii (strain CH1 / JCM 16557)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei274ATPUniRule annotation1
Active sitei276N6-AMP-lysine intermediateUniRule annotation1
Binding sitei281ATPUniRule annotation1
Binding sitei296ATPUniRule annotation1
Binding sitei326ATPUniRule annotation1
Binding sitei366ATPUniRule annotation1
Binding sitei441ATPUniRule annotation1
Binding sitei447ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PYCH_03680Imported
OrganismiPyrococcus yayanosii (strain CH1 / JCM 16557)Imported
Taxonomic identifieri529709 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000008386 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi529709.PYCH_03680

Structurei

3D structure databases

ProteinModelPortaliF8AH01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini354 – 482DNA_LIGASE_A3InterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS00333 DNA_LIGASE_A2, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F8AH01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDGWRDIK VVRNPYFSLR IVPTVVPMRY LELAQLYQRL EKTTLKTLKT
60 70 80 90 100
RLVADFLKKV PNDLLEIIPY LILGDVFPEW DERELGVGEK LLIRAVSMAT
110 120 130 140 150
GVDAKEIENS VKETGDLGES VALAIKKRKQ RSFFSQPLTI KRVYDTLVKV
160 170 180 190 200
AEISGEGSQD KKLKYLANLF MDAEPIEAKY LARTILGIMR TGVAEGILRD
210 220 230 240 250
AIAEAFHVKV ELVERAYMLT SDFGFVTKVA KLEGNEGLAK VTIQVGKPIK
260 270 280 290 300
PMLAQQAASI KDALLEMGGE AEFEIKYDGA RVQVHKDGDR IIVYSRRLEN
310 320 330 340 350
VTRSIPEVVE RLKRAIKAEK AIVEGELVAV GEDGRPLPFQ YVLRRFRRKY
360 370 380 390 400
NIEEMIEKIP LELNLFDVLY VGGKALIDEP FIERRKTLEG IIEADGWIKV
410 420 430 440 450
AENLITKSVE EAESFYRKAL GMGHEGLMAK RLDSVYEPGN RGKKWLKIKP
460 470 480 490 500
TMENLDLVII GAEWGEGRRA HVFGSFILGA YDPHTGEFVE VGKVGSGFTD
510 520 530 540 550
EDLIEFTKML KRLITKEEGK RVWFEPKVVI EVTYQEIQKS PKYRSGFALR
560 570 580
FPRYVALRDD KGPEDADTIE RIAQLYELQE RMKGKKIA
Length:588
Mass (Da):66,835
Last modified:September 21, 2011 - v1
Checksum:i97387297BC0BFCE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002779 Genomic DNA Translation: AEH24059.1

Genome annotation databases

EnsemblBacteriaiAEH24059; AEH24059; PYCH_03680
KEGGipya:PYCH_03680

Similar proteinsi

Entry informationi

Entry nameiF8AH01_PYRYC
AccessioniPrimary (citable) accession number: F8AH01
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 25, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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