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F8AH01

- F8AH01_PYRYC

UniProt

F8AH01 - F8AH01_PYRYC

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Protein

DNA ligase

Gene
lig, PYCH_03680
Organism
Pyrococcus yayanosii (strain CH1 / JCM 16557)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei274 – 2741ATP By similarityUniRule annotation
Active sitei276 – 2761N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei281 – 2811ATP By similarityUniRule annotation
Binding sitei296 – 2961ATP By similarityUniRule annotation
Binding sitei326 – 3261ATP By similarityUniRule annotation
Binding sitei366 – 3661ATP By similarityUniRule annotation
Binding sitei441 – 4411ATP By similarityUniRule annotation
Binding sitei447 – 4471ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPYAY529709:GHZ0-374-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PYCH_03680Imported
OrganismiPyrococcus yayanosii (strain CH1 / JCM 16557)Imported
Taxonomic identifieri529709 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000008386: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF8AH01.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F8AH01-1 [UniParc]FASTAAdd to Basket

« Hide

MEGDGWRDIK VVRNPYFSLR IVPTVVPMRY LELAQLYQRL EKTTLKTLKT    50
RLVADFLKKV PNDLLEIIPY LILGDVFPEW DERELGVGEK LLIRAVSMAT 100
GVDAKEIENS VKETGDLGES VALAIKKRKQ RSFFSQPLTI KRVYDTLVKV 150
AEISGEGSQD KKLKYLANLF MDAEPIEAKY LARTILGIMR TGVAEGILRD 200
AIAEAFHVKV ELVERAYMLT SDFGFVTKVA KLEGNEGLAK VTIQVGKPIK 250
PMLAQQAASI KDALLEMGGE AEFEIKYDGA RVQVHKDGDR IIVYSRRLEN 300
VTRSIPEVVE RLKRAIKAEK AIVEGELVAV GEDGRPLPFQ YVLRRFRRKY 350
NIEEMIEKIP LELNLFDVLY VGGKALIDEP FIERRKTLEG IIEADGWIKV 400
AENLITKSVE EAESFYRKAL GMGHEGLMAK RLDSVYEPGN RGKKWLKIKP 450
TMENLDLVII GAEWGEGRRA HVFGSFILGA YDPHTGEFVE VGKVGSGFTD 500
EDLIEFTKML KRLITKEEGK RVWFEPKVVI EVTYQEIQKS PKYRSGFALR 550
FPRYVALRDD KGPEDADTIE RIAQLYELQE RMKGKKIA 588
Length:588
Mass (Da):66,835
Last modified:September 21, 2011 - v1
Checksum:i97387297BC0BFCE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002779 Genomic DNA. Translation: AEH24059.1.
RefSeqiYP_004623331.1. NC_015680.1.

Genome annotation databases

EnsemblBacteriaiAEH24059; AEH24059; PYCH_03680.
GeneIDi10836944.
KEGGipya:PYCH_03680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002779 Genomic DNA. Translation: AEH24059.1 .
RefSeqi YP_004623331.1. NC_015680.1.

3D structure databases

ProteinModelPortali F8AH01.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH24059 ; AEH24059 ; PYCH_03680 .
GeneIDi 10836944.
KEGGi pya:PYCH_03680.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci PYAY529709:GHZ0-374-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the obligate piezophilic hyperthermophilic archaeon Pyrococcus yayanosii CH1."
    Jun X., Lupeng L., Minjuan X., Oger P., Fengping W., Jebbar M., Xiang X.
    J. Bacteriol. 193:4297-4298(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH1 / JCM 16557.

Entry informationi

Entry nameiF8AH01_PYRYC
AccessioniPrimary (citable) accession number: F8AH01
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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