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F8AF48

- F8AF48_PYRYC

UniProt

F8AF48 - F8AF48_PYRYC

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Protein

Ribulose bisphosphate carboxylase

Gene
rbcL, PYCH_00090
Organism
Pyrococcus yayanosii (strain CH1 / JCM 16557)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei156 – 1561Proton acceptor By similarityUniRule annotation
Binding sitei158 – 1581Substrate By similarityUniRule annotation
Metal bindingi182 – 1821Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi184 – 1841Magnesium By similarityUniRule annotation
Metal bindingi185 – 1851Magnesium By similarityUniRule annotation
Active sitei274 – 2741Proton acceptor By similarityUniRule annotation
Binding sitei275 – 2751Substrate By similarityUniRule annotation
Binding sitei307 – 3071Substrate By similarityUniRule annotation
Sitei314 – 3141Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. oxidoreductase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. carbon fixation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotation, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPYAY529709:GHZ0-9-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotation
Ordered Locus Names:PYCH_00090Imported
OrganismiPyrococcus yayanosii (strain CH1 / JCM 16557)Imported
Taxonomic identifieri529709 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
ProteomesiUP000008386: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei182 – 1821N6-carboxylysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF8AF48.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 3463Substrate binding By similarityUniRule annotation
Regioni366 – 3694Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK01601.
OMAiIFRESHY.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01133. RuBisCO_L_type3.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

F8AF48-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVEWYLDF VDLDYTPGRD ELIVEYYFEP NGVSPEEAAG RIASESSIGT    50
WTTLWKLPDM AKRSMAKVFS LEKSGEGYIA KIAYPLTLFE EGNLVQLFSA 100
IAGNIFGMKA LKNLRLLDFH PPYEYLRHFK GPQYGVKGIR EFMGIEDRPL 150
TATVPKPKMG WSVDEYAEIA YELWSGGIDL LKDDENFTSF PFNRFEERVR 200
KLYAVRDRVE AETGETKEYL INITGPAHVM EKRAQLVAAE GGQYIMIDIV 250
VVGWSALQYM REVAEDLGLA IHAHRAMHAA FTRNPRHGIS MFVLAKAARM 300
VGVDQIHTGT AVGKMAGDYE EVKRINGFLL SEWEHIKPIF PVASGGLHPG 350
LMPELIRLFG RDLVIQVGGG VMGHPDGPRA GAKALRDAIE AAIEGVSLEE 400
KAKESPELKK ALEKWGYLKP K 421
Length:421
Mass (Da):47,126
Last modified:September 21, 2011 - v1
Checksum:iDC4D0153E37B1599
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002779 Genomic DNA. Translation: AEH23722.1.
RefSeqiYP_004622994.1. NC_015680.1.

Genome annotation databases

EnsemblBacteriaiAEH23722; AEH23722; PYCH_00090.
GeneIDi10836592.
KEGGipya:PYCH_00090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002779 Genomic DNA. Translation: AEH23722.1 .
RefSeqi YP_004622994.1. NC_015680.1.

3D structure databases

ProteinModelPortali F8AF48.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH23722 ; AEH23722 ; PYCH_00090 .
GeneIDi 10836592.
KEGGi pya:PYCH_00090.

Phylogenomic databases

KOi K01601.
OMAi IFRESHY.

Enzyme and pathway databases

BioCyci PYAY529709:GHZ0-9-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01133. RuBisCO_L_type3.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the obligate piezophilic hyperthermophilic archaeon Pyrococcus yayanosii CH1."
    Jun X., Lupeng L., Minjuan X., Oger P., Fengping W., Jebbar M., Xiang X.
    J. Bacteriol. 193:4297-4298(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CH1 / JCM 16557.

Entry informationi

Entry nameiF8AF48_PYRYC
AccessioniPrimary (citable) accession number: F8AF48
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi