ID   F8AEB6_PYRYC            Unreviewed;       606 AA.
AC   F8AEB6;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=aldehyde ferredoxin oxidoreductase {ECO:0000256|ARBA:ARBA00012818};
DE            EC=1.2.7.5 {ECO:0000256|ARBA:ARBA00012818};
GN   OrderedLocusNames=PYCH_09430 {ECO:0000313|EMBL:AEH24628.1};
OS   Pyrococcus yayanosii (strain CH1 / JCM 16557).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=529709 {ECO:0000313|EMBL:AEH24628.1, ECO:0000313|Proteomes:UP000008386};
RN   [1] {ECO:0000313|EMBL:AEH24628.1, ECO:0000313|Proteomes:UP000008386}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH1 / JCM 16557 {ECO:0000313|Proteomes:UP000008386};
RX   PubMed=21705594; DOI=10.1128/JB.05345-11;
RA   Jun X., Lupeng L., Minjuan X., Oger P., Fengping W., Jebbar M., Xiang X.;
RT   "Complete genome sequence of the obligate piezophilic hyperthermophilic
RT   archaeon Pyrococcus yayanosii CH1.";
RL   J. Bacteriol. 193:4297-4298(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a
CC         carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:16421, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17478,
CC         ChEBI:CHEBI:29067, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738; EC=1.2.7.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001714};
CC   -!- COFACTOR:
CC       Name=W-bis(molybdopterin guanine dinucleotide); Xref=ChEBI:CHEBI:60537;
CC         Evidence={ECO:0000256|ARBA:ARBA00001930};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966};
CC   -!- SIMILARITY: Belongs to the AOR/FOR family.
CC       {ECO:0000256|ARBA:ARBA00011032}.
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DR   EMBL; CP002779; AEH24628.1; -; Genomic_DNA.
DR   RefSeq; WP_013905685.1; NC_015680.1.
DR   AlphaFoldDB; F8AEB6; -.
DR   STRING; 529709.PYCH_09430; -.
DR   GeneID; 10837518; -.
DR   KEGG; pya:PYCH_09430; -.
DR   eggNOG; arCOG00706; Archaea.
DR   HOGENOM; CLU_020364_1_0_2; -.
DR   OrthoDB; 30771at2157; -.
DR   Proteomes; UP000008386; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 2; 1.
DR   Gene3D; 1.10.599.10; Aldehyde Ferredoxin Oxidoreductase Protein, subunit A, domain 3; 1.
DR   Gene3D; 3.60.9.10; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   PANTHER; PTHR30038; ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   PANTHER; PTHR30038:SF0; TUNGSTEN-CONTAINING ALDEHYDE FERREDOXIN OXIDOREDUCTASE; 1.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; Aldehyde ferredoxin oxidoreductase, C-terminal domains; 1.
DR   SUPFAM; SSF56228; Aldehyde ferredoxin oxidoreductase, N-terminal domain; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Tungsten {ECO:0000256|ARBA:ARBA00023245}.
FT   DOMAIN          4..207
FT                   /note="Aldehyde ferredoxin oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00790"
SQ   SEQUENCE   606 AA;  67230 MW;  A0E6F56C66237039 CRC64;
     MFGYNGKILR VNLSDETIKE ETFNEAFAKR WLGTRGFGIY YLLKEIDPTI DPFSPENKLI
     FATGPLTGTS APTGGRYMVI TKSPLTEYVA MANSGGFFGP ELKFAGWDAL IIEGKANHPV
     YIYINDESVE IKDASHLWGK VVSETEERLK EEVGDKNVQI ASIGPAGENK VRFAAVMNNG
     HRAAGRGGVG AVMGSKNLKA IVVRGHKKVE VADKGKFMEV VREKIEKLKK DPVAGGGLPK
     YGTAVLVNII NENGLYPTRN FQKGVFEYAY EQSGEAMAAK YLTKNKPCFA CPIGCGRVNR
     LPTLGITEGP EYESVWALGA NLGINDLASI IEANHLADEF GMDTISLGGT LATAMELYEK
     GLLKQEDIGE DAPPFRWGNT EVLHYYVEKI ARREGFGDVL AEGGYRLAEK FNGLEYFMGV
     KKQELPAYDP RGAEGHGLGY ATNNRGGCHI KQYMISPEIL GYPYKMDPHD ISDEKVKMVI
     LFQDLTALVD AAGLCVFTTF GLGADDYRDL LNAALGWDFS TEDYLKIGER IWNAERLFNL
     KAGLDPVKED TLPKRLLEEP MPEGPHKGHV VRLKEMLPRY YKFRGWTEDG RIPEEKLKEL
     GLEEFI
//