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F8A9U8 (F8A9U8_THEID) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Thein_0262 EMBL AEH44146.1
OrganismThermodesulfatator indicus (strain DSM 15286 / JCM 11887 / CIR29812) [Complete proteome] [HAMAP] EMBL AEH44146.1
Taxonomic identifier667014 [NCBI]
Taxonomic lineageBacteriaThermodesulfobacteriaThermodesulfobacterialesThermodesulfobacteriaceaeThermodesulfatator

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011127

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011127

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011127

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011127

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011127.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011127

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain102 – 295194ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding130 – 18051ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2501Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2621Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2621Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2641Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8A9U8 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: C99DBCFDE5A2D1AF

FASTA30132,344
        10         20         30         40         50         60 
MMLKVALLCG GKSAEREVSL KGGQAVAAAL KKLGHQFKIF DPAKDLPLLA QETKNYNVAF 

        70         80         90        100        110        120 
LVLHGPGGED GTIQGFLDSL GLSYQGAGVL GSALAMDKAL SKILYQEAGL LVPKGLVLEK 

       130        140        150        160        170        180 
NKPLPQINFF PLVVKPVSQG SSVGISIVRT PDELDSALEA AFALEERVLV EEYLEGRELT 

       190        200        210        220        230        240 
VGILGEEALP VVEIIPGEGH TFFDYQAKYT PGVTQELCPA PIPEEIAREA QRAALAAHQA 

       250        260        270        280        290        300 
LRLRHYSRTD FILVGERLYV LETNTIPGMT ETSLLPLAAK VAGYPFEDLV QKLLDLALTA 


A 

« Hide

References

[1]"The complete genome of Thermodesulfatator indicus DSM 15286."
Lucas S., Copeland A., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L., Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Saunders L., Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V. expand/collapse author list , Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 15286 / JCM 11887 / CIR29812.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002683 Genomic DNA. Translation: AEH44146.1.
RefSeqYP_004625110.1. NC_015681.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH44146; AEH44146; Thein_0262.
GeneID10840489.
KEGGtid:Thein_0262.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycTIND667014:GI6G-265-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8A9U8_THEID
AccessionPrimary (citable) accession number: F8A9U8
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)