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F8A1C6 (F8A1C6_CELGA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Celgi_1154 EMBL AEI11673.1
OrganismCellvibrio gilvus (strain ATCC 13127 / NRRL B-14078) [Complete proteome] [HAMAP] EMBL AEI11673.1
Taxonomic identifier593907 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeCellulomonadaceaeCellulomonas

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain161 – 372212ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding193 – 24856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3261Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3391Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3391Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3411Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F8A1C6 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: E6EF1077CC40DAB5

FASTA38240,607
        10         20         30         40         50         60 
MNAVPSPQSL DDAVRRPRVM VLFGGRSGEH AISCATAGGV LRALDRERYD VVAVGVTPTG 

        70         80         90        100        110        120 
RWVLADDDPD RWAITDGRLP QVEDTASHVV LPSDTGDRDV LVVQDGGAPR SIGEIDVVFP 

       130        140        150        160        170        180 
LLHGPFGEDG TLQGMLELAD VRYVGAGVLA SAVGMDKHMM KVVFEGHGLP VSPFVTVLPG 

       190        200        210        220        230        240 
AFARDPEGIT ARVAALGLPV FVKPARAGSS LGISRVTDLA DLPAAIAAAH EHDPKVVVEA 

       250        260        270        280        290        300 
AVVGREIECG VLGGRGGRRP RASLPGEIVV DHGKHAFYDF EAKYLDESAV RLACPADLSP 

       310        320        330        340        350        360 
DAVARVQEVA VRAFEALGCE GLARVDVFVT EDDQVVVNEI NTMPGFTPFS MYPRMWQSSG 

       370        380 
LSYPELVDEL VQLALERPTG LR 

« Hide

References

[1]"Complete sequence of Cellvibrio gilvus ATCC 13127."
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Munk A., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Mead D., Brumm P., Woyke T.
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13127 / NRRL B-14078.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002665 Genomic DNA. Translation: AEI11673.1.
RefSeqYP_004600241.1. NC_015671.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEI11673; AEI11673; Celgi_1154.
GeneID10812170.
KEGGcga:Celgi_1154.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF8A1C6_CELGA
AccessionPrimary (citable) accession number: F8A1C6
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: February 19, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)