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Protein

Malate dehydrogenase

Gene

mdh

Organism
Roseobacter litoralis (strain ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported
Biological processTricarboxylic acid cycleUniRule annotationSAAS annotation
LigandNADUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotationImported
Ordered Locus Names:RLO149_c030910Imported
OrganismiRoseobacter litoralis (strain ATCC 49566 / DSM 6996 / JCM 21268 / NBRC 15278 / OCh 149)Imported
Taxonomic identifieri391595 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRoseobacter
Proteomesi
  • UP000001353 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi391595.RLO149_c030910.

Structurei

3D structure databases

ProteinModelPortaliF7ZIY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 143Ldh_1_NInterPro annotationAdd BLAST139
Domaini147 – 306Ldh_1_CInterPro annotationAdd BLAST160

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
KOiK00024.
OMAiICIIANP.
OrthoDBiPOG091H02N6.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

F7ZIY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPKIALIG AGQIGGTLAH LAALKELGDV VLFDIAEGVP EGKALDIAES
60 70 80 90 100
GPSAKFDARM SGTQSYADIA GADVCIVTAG VARKPGMSRD DLLGINLKVM
110 120 130 140 150
KSVGEGIAAH APDAFVICIT NPLDAMVWAL REFSGLPHEK VCGMAGVLDS
160 170 180 190 200
ARFRHFLADE FDVSMKDVTA FVLGGHGDTM VPLVRYSTVA GIPLPDLVKM
210 220 230 240 250
GWTTQDKLDA IVQRTRDGGA EIVGLLKTGS AFYAPATSAI EMAESYLKDQ
260 270 280 290 300
KRVLPCAAYV DGAYGLKGFY VGVPTVIGAG GIERVVEISM NKDEQAMFDS
310 320
SVKAVKGLVT ACKGIDDSLS
Length:320
Mass (Da):33,525
Last modified:September 21, 2011 - v1
Checksum:i51408FB529DFC007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002623 Genomic DNA. Translation: AEI95047.1.
RefSeqiWP_013962957.1. NC_015730.1.

Genome annotation databases

EnsemblBacteriaiAEI95047; AEI95047; RLO149_c030910.
KEGGirli:RLO149_c030910.

Similar proteinsi

Entry informationi

Entry nameiF7ZIY7_ROSLO
AccessioniPrimary (citable) accession number: F7ZIY7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 22, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported