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F7YW42

- F7YW42_9THEM

UniProt

F7YW42 - F7YW42_9THEM

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Protein
Thymidine kinase
Gene
tdk, Theth_0436
Organism
Thermotoga thermarum DSM 5069
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP By similarityUniRule annotation
Nucleotide bindingi83 – 864ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingSAAS annotations, Nucleotide-binding, ZincSAAS annotations

Enzyme and pathway databases

BioCyciTTHE688269:GHXV-449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:Theth_0436Imported
OrganismiThermotoga thermarum DSM 5069Imported
Taxonomic identifieri688269 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000006804: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7YW42-1 [UniParc]FASTAAdd to Basket

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MAGKLTMIVG PMYSGKTTEL LSFVEIYKLG RKKFKVFKPA IDDRYGKSLV    50
KTHTGLEVEA IAVEGSKDIV NLLEEKIDAV FIDEVQFFDK DLVRIVKQLI 100
DSNVDVFCAG LDMTFKQNPF ETTAALMAIA DEVIKKKAVC EVCGEYKANL 150
TYKVTEEEKE IDIGGKEKYI AVCRDCYNNL SKERIK 186
Length:186
Mass (Da):20,982
Last modified:September 21, 2011 - v1
Checksum:iB3E9DA2D0FE74E95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002351 Genomic DNA. Translation: AEH50531.1.
RefSeqiWP_013931754.1. NC_015707.1.
YP_004659627.1. NC_015707.1.

Genome annotation databases

EnsemblBacteriaiAEH50531; AEH50531; Theth_0436.
GeneIDi10885189.
KEGGitta:Theth_0436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002351 Genomic DNA. Translation: AEH50531.1 .
RefSeqi WP_013931754.1. NC_015707.1.
YP_004659627.1. NC_015707.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH50531 ; AEH50531 ; Theth_0436 .
GeneIDi 10885189.
KEGGi tta:Theth_0436.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci TTHE688269:GHXV-449-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 5069Imported.

Entry informationi

Entry nameiF7YW42_9THEM
AccessioniPrimary (citable) accession number: F7YW42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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