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F7YW42

- F7YW42_9THEM

UniProt

F7YW42 - F7YW42_9THEM

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Protein

Thymidine kinase

Gene

tdk

Organism
Thermotoga thermarum DSM 5069
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation
Nucleotide bindingi83 – 864ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingSAAS annotation, Nucleotide-binding, ZincSAAS annotation

Enzyme and pathway databases

BioCyciTTHE688269:GHXV-449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:Theth_0436Imported
OrganismiThermotoga thermarum DSM 5069Imported
Taxonomic identifieri688269 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000006804: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7YW42-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKLTMIVG PMYSGKTTEL LSFVEIYKLG RKKFKVFKPA IDDRYGKSLV
60 70 80 90 100
KTHTGLEVEA IAVEGSKDIV NLLEEKIDAV FIDEVQFFDK DLVRIVKQLI
110 120 130 140 150
DSNVDVFCAG LDMTFKQNPF ETTAALMAIA DEVIKKKAVC EVCGEYKANL
160 170 180
TYKVTEEEKE IDIGGKEKYI AVCRDCYNNL SKERIK
Length:186
Mass (Da):20,982
Last modified:September 21, 2011 - v1
Checksum:iB3E9DA2D0FE74E95
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002351 Genomic DNA. Translation: AEH50531.1.
RefSeqiWP_013931754.1. NC_015707.1.
YP_004659627.1. NC_015707.1.

Genome annotation databases

EnsemblBacteriaiAEH50531; AEH50531; Theth_0436.
GeneIDi10885189.
KEGGitta:Theth_0436.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002351 Genomic DNA. Translation: AEH50531.1 .
RefSeqi WP_013931754.1. NC_015707.1.
YP_004659627.1. NC_015707.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH50531 ; AEH50531 ; Theth_0436 .
GeneIDi 10885189.
KEGGi tta:Theth_0436.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci TTHE688269:GHXV-449-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DSM 5069Imported.

Entry informationi

Entry nameiF7YW42_9THEM
AccessioniPrimary (citable) accession number: F7YW42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3