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Protein
Submitted name:

D-alanine--D-alanine ligase

Gene

Theth_1510

Organism
Pseudothermotoga thermarum DSM 5069
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotationImported

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE688269:GHXV-1492-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Submitted name:
D-alanine--D-alanine ligaseImported (EC:6.3.2.4Imported)
Gene namesi
ORF Names:Theth_1510Imported
OrganismiPseudothermotoga thermarum DSM 5069Imported
Taxonomic identifieri688269 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaePseudothermotoga
Proteomesi
  • UP000006804 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi688269.Theth_1510.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 297ATP-graspInterPro annotationAdd BLAST204

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4108N9N. Bacteria.
COG1181. LUCA.
KOiK01921.
OrthoDBiPOG091H1LUD.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7YTY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKVAVVFDM VNLDEERKRM IDAVASALSK KFEVEKLPFD DDFVKKVKKF
60 70 80 90 100
DAVFNLSTAY KQIHVPAILD VLNIPYTGSD ALAHALCIDK VITKTILVQN
110 120 130 140 150
NVPTPEFVAV EVGQLPPQID FYPAIVKPSR QGSAKGIHAD SVVHNYDELC
160 170 180 190 200
RIVKRVHEQF NEPALVEKFI EGKELSVGIV AGEVLPILEI DFSELGEGLE
210 220 230 240 250
RFYSYRVKHY YGDKTKYYCP ARIDETVRKK IEFYAKRAFE ALRLKNYARM
260 270 280 290 300
DLRLKDDEIY FLEVNSLPML TPGYSDIIKM AEATGYSYDE LILKIFEDGV

MKCFGT
Length:306
Mass (Da):34,914
Last modified:September 21, 2011 - v1
Checksum:iA9F39B1BA74A9375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002351 Genomic DNA. Translation: AEH51563.1.

Genome annotation databases

EnsemblBacteriaiAEH51563; AEH51563; Theth_1510.
KEGGitta:Theth_1510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002351 Genomic DNA. Translation: AEH51563.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi688269.Theth_1510.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH51563; AEH51563; Theth_1510.
KEGGitta:Theth_1510.

Phylogenomic databases

eggNOGiENOG4108N9N. Bacteria.
COG1181. LUCA.
KOiK01921.
OrthoDBiPOG091H1LUD.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciTTHE688269:GHXV-1492-MONOMER.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR011095. Dala_Dala_lig_C.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF7YTY1_9THEM
AccessioniPrimary (citable) accession number: F7YTY1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.