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Protein

Multifunctional fusion protein

Gene

trpF

Organism
Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.UniRule annotationSAAS annotation
N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 and 4 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (VAA_02247)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. Multifunctional fusion protein (trpF)
  4. Multifunctional fusion protein (trpF)
  5. Tryptophan synthase alpha chain (trpA), Tryptophan synthase beta chain (trpB)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, IsomeraseUniRule annotation, Lyase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVANG882102:G12Y6-1976-MONOMER.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Multifunctional fusion proteinUniRule annotation
Including the following 2 domains:
Indole-3-glycerol phosphate synthaseUniRule annotation (EC:4.1.1.48UniRule annotation)
Short name:
IGPSUniRule annotation
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Synonyms:trpCUniRule annotation
Ordered Locus Names:VAA_02250Imported
OrganismiVibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)Imported
Taxonomic identifieri882102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000006800 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi882102.VAA_02250.

Structurei

3D structure databases

ProteinModelPortaliF7YLB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 266IGPSInterPro annotationAdd BLAST247
Domaini272 – 464PRAIInterPro annotationAdd BLAST193

Sequence similaritiesi

Belongs to the TrpC family.UniRule annotation
Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DK0. Bacteria.
COG0134. LUCA.
COG0135. LUCA.
KOiK13498.
OMAiYDIIGIN.
OrthoDBiPOG091H02GI.

Family and domain databases

CDDicd00331. IGPS. 1 hit.
cd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B. 1 hit.
MF_00135. PRAI. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiView protein in PROSITE
PS00614. IGPS. 1 hit.

Sequencei

Sequence statusi: Complete.

F7YLB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEQLSDHIS TQHTQMAEVL AKIVNDKYEW VEQRKTQQPL GSFEHLLTAS
60 70 80 90 100
DRSFYDALNT GKTAFILECK KASPSKGLIR QDFDLDYIAS VYHQYADAIS
110 120 130 140 150
VLTDEKYFQG NLEFLPRVRA QVSQPVICKD FMVDVYQVYL ARHYSADAIL
160 170 180 190 200
LMLSVLDDQH YQTLANVAHQ LGMGILTEVS NEEELHRAVA LQAKVIGINN
210 220 230 240 250
RNLRDLSTDL NRTKQLAPLL PEGTMIISES GIYTHQQVRE LSQYANGFLI
260 270 280 290 300
GSSLMAEENL ELAVRKVTLG ENKVCGLTHA DDAAKAYQAG AVFGGLIFVP
310 320 330 340 350
QSKRYVDLDN ARLTMSGAPL RYVGVFQNHT IEAITQIATT LKLFAVQLHG
360 370 380 390 400
EEDQAYVDQL RAHLPSQIEI WKAYGVSDCL PTKLERHIDR HLFDAKVGTQ
410 420 430 440 450
SGGTGQRFDW QLLTKINDVM LAGGLSPENA QQAANIGCLG LDLNSGVESE
460
PGKKDLHKLT LAFDAIRQY
Length:469
Mass (Da):52,294
Last modified:September 21, 2011 - v1
Checksum:i3E55D784C69CDD89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH33510.1.
RefSeqiWP_013857144.1. NC_015633.1.

Genome annotation databases

EnsemblBacteriaiAEH33510; AEH33510; VAA_02250.
GeneIDi10775754.
KEGGivan:VAA_02250.
PATRICifig|882102.3.peg.1932.

Similar proteinsi

Entry informationi

Entry nameiF7YLB1_VIBA7
AccessioniPrimary (citable) accession number: F7YLB1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 25, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported