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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotationSAAS annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mn2+Note: Binds 2 manganese ions per subunit.
  • Mn2+UniRule annotationSAAS annotationNote: Binds 2 manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Manganese 2UniRule annotation
Active sitei63 – 631Phosphoserine intermediateUniRule annotation
Metal bindingi63 – 631Manganese 2UniRule annotation
Metal bindingi401 – 4011Manganese 1UniRule annotation
Metal bindingi405 – 4051Manganese 1UniRule annotation
Metal bindingi442 – 4421Manganese 2UniRule annotation
Metal bindingi443 – 4431Manganese 2UniRule annotation
Metal bindingi461 – 4611Manganese 1UniRule annotation

GO - Molecular functioni

  1. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glucose catabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLANG882102:GIWG-2886-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotationSAAS annotation (EC:5.4.2.12UniRule annotationSAAS annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Ordered Locus Names:VAA_00342Imported
OrganismiVibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)Imported
Taxonomic identifieri882102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000006800 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF7YIU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotation

Phylogenomic databases

KOiK15633.
OMAiIENYMQE.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

F7YIU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKPMALV ILDGWGYRED NAHNAISNAH TPVMDSLIAN NPNTLISASG
60 70 80 90 100
MDVGLPDGQM GNSEVGHTNI GAGRIVYQDL TRITKSILDG EFQQNEVLVN
110 120 130 140 150
AMDKAIKAGK AVHLLGLMSP GGVHSHEDHI YAAVEMAAAR GAEKIYLHCF
160 170 180 190 200
LDGRDTPPRS AEASLQRFQD LFSKLGKGRI ASLIGRYYAM DRDNNWERVQ
210 220 230 240 250
KAYDLLVEAK AEFTFDSAVA GLEAAYAREE NDEFVKATEI KAEGQDSAAI
260 270 280 290 300
EDGDAVIFMN YRADRAREIT RAFIPDFNGF ERAKFPAIDF VMLTQYAADI
310 320 330 340 350
PLLCAFPPAS LENTYGEWLS KAGKTQLRIS ETEKYAHVTF FFNGGVENEF
360 370 380 390 400
PGEERQLVAS PKVATYDLQP EMSAPELTEK LVAAIKSGKY DAIICNYPNG
410 420 430 440 450
DMVGHTGIYE AAVKACEALD ECIGKVVEAI KEVDGQLLIT ADHGNAEMMV
460 470 480 490 500
NPETGGIHTA HTNLPVPLIY VGSKDLKLKD GGKLSDLAPT MLALSNMDIP
510
AEMSGQVLFK
Length:510
Mass (Da):55,562
Last modified:September 21, 2011 - v1
Checksum:i6F07808ED023E670
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH34380.1.
RefSeqiYP_004567422.1. NC_015633.1.

Genome annotation databases

EnsemblBacteriaiAEH34380; AEH34380; VAA_00342.
KEGGivan:VAA_00342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH34380.1.
RefSeqiYP_004567422.1. NC_015633.1.

3D structure databases

ProteinModelPortaliF7YIU2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH34380; AEH34380; VAA_00342.
KEGGivan:VAA_00342.

Phylogenomic databases

KOiK15633.
OMAiIENYMQE.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciLANG882102:GIWG-2886-MONOMER.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the marine fish pathogen Vibrio anguillarum harboring the pJM1 virulence plasmid and genomic comparison with other virulent strains of V. anguillarum and V. ordalii."
    Naka H., Dias G.M., Thompson C.C., Dubay C., Thompson F.L., Crosa J.H.
    Infect. Immun. 79:2889-2900(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 68554 / 775Imported.

Entry informationi

Entry nameiF7YIU2_VIBA7
AccessioniPrimary (citable) accession number: F7YIU2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 1, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.