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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotationSAAS annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (VAA_01561), Pyruvate kinase (VAA_03328), Pyruvate kinase (VAA_00177)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi13Manganese 2UniRule annotation1
Active sitei63Phosphoserine intermediateUniRule annotation1
Metal bindingi63Manganese 2UniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Binding sitei186SubstrateUniRule annotation1
Binding sitei192SubstrateUniRule annotation1
Binding sitei334SubstrateUniRule annotation1
Metal bindingi401Manganese 1UniRule annotation1
Metal bindingi405Manganese 1UniRule annotation1
Metal bindingi442Manganese 2UniRule annotation1
Metal bindingi443Manganese 2UniRule annotation1
Metal bindingi461Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotation
Ordered Locus Names:VAA_00342Imported
OrganismiVibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)Imported
Taxonomic identifieri882102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000006800 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi882102.VAA_00342.

Structurei

3D structure databases

ProteinModelPortaliF7YIU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 497MetalloenzymeInterPro annotationAdd BLAST493
Domaini83 – 297iPGM_NInterPro annotationAdd BLAST215

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Substrate bindingUniRule annotation2
Regioni262 – 265Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
KOiK15633.
OMAiIENYMQE.
OrthoDBiPOG091H01EL.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

F7YIU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKPMALV ILDGWGYRED NAHNAISNAH TPVMDSLIAN NPNTLISASG
60 70 80 90 100
MDVGLPDGQM GNSEVGHTNI GAGRIVYQDL TRITKSILDG EFQQNEVLVN
110 120 130 140 150
AMDKAIKAGK AVHLLGLMSP GGVHSHEDHI YAAVEMAAAR GAEKIYLHCF
160 170 180 190 200
LDGRDTPPRS AEASLQRFQD LFSKLGKGRI ASLIGRYYAM DRDNNWERVQ
210 220 230 240 250
KAYDLLVEAK AEFTFDSAVA GLEAAYAREE NDEFVKATEI KAEGQDSAAI
260 270 280 290 300
EDGDAVIFMN YRADRAREIT RAFIPDFNGF ERAKFPAIDF VMLTQYAADI
310 320 330 340 350
PLLCAFPPAS LENTYGEWLS KAGKTQLRIS ETEKYAHVTF FFNGGVENEF
360 370 380 390 400
PGEERQLVAS PKVATYDLQP EMSAPELTEK LVAAIKSGKY DAIICNYPNG
410 420 430 440 450
DMVGHTGIYE AAVKACEALD ECIGKVVEAI KEVDGQLLIT ADHGNAEMMV
460 470 480 490 500
NPETGGIHTA HTNLPVPLIY VGSKDLKLKD GGKLSDLAPT MLALSNMDIP
510
AEMSGQVLFK
Length:510
Mass (Da):55,562
Last modified:September 21, 2011 - v1
Checksum:i6F07808ED023E670
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH34380.1.
RefSeqiWP_013857941.1. NC_015633.1.

Genome annotation databases

EnsemblBacteriaiAEH34380; AEH34380; VAA_00342.
GeneIDi10776664.
KEGGivan:VAA_00342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH34380.1.
RefSeqiWP_013857941.1. NC_015633.1.

3D structure databases

ProteinModelPortaliF7YIU2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882102.VAA_00342.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH34380; AEH34380; VAA_00342.
GeneIDi10776664.
KEGGivan:VAA_00342.

Phylogenomic databases

eggNOGiENOG4105CJI. Bacteria.
COG0696. LUCA.
KOiK15633.
OMAiIENYMQE.
OrthoDBiPOG091H01EL.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
HAMAPiMF_01038. GpmI. 1 hit.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF7YIU2_VIBA7
AccessioniPrimary (citable) accession number: F7YIU2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: November 30, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.