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Protein

Alanine racemase

Gene

VAA_00263

Organism
Vibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (VAA_00263), Alanine racemase (VAA_01439)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Active sitei257Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei305Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciVANG882102:G12Y6-2851-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:VAA_00263Imported
OrganismiVibrio anguillarum (strain ATCC 68554 / 775) (Listonella anguillarum)Imported
Taxonomic identifieri882102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000006800 Componenti: Chromosome I

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi882102.VAA_00263.

Structurei

3D structure databases

ProteinModelPortaliF7YIR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 360Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiTHAKNQM.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

F7YIR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYMKAATAC IDLDALKHNL QRVKQQAPNS KIMAVVKANG YGHGLRHVAK
60 70 80 90 100
HALGADAFGV ARIEEALQLR ASGVVKPILL LEGFYSPMDL AVLVTNNIQT
110 120 130 140 150
VVHCEEQLVA LEKAQLDVPV NVWLKIDSGM HRLGVRPEQY PDFLERLQAC
160 170 180 190 200
KNVVKPLRYM SHFGCADELD KSTTSEQIEL FLAMTKGHEG ERSLAASAGL
210 220 230 240 250
LAWKHSQLEW VRPGIIMYGV SPFDDNSAQA LGYQPVMTLK SHLIAVRDVK
260 270 280 290 300
AGESVGYGAT WTSLRDTKVG VIAIGYGDGY PRTAPNGTPV VVNGRKVPIA
310 320 330 340 350
GRVSMDMLTV DLGPQACDKV GDEVILWGKE LPAEEVASHI GTIAYELVTK
360
LTSRVEMSYQ
Length:360
Mass (Da):39,274
Last modified:September 21, 2011 - v1
Checksum:i3A108C6FC071F693
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH34346.1.
RefSeqiWP_013857914.1. NC_015633.1.

Genome annotation databases

EnsemblBacteriaiAEH34346; AEH34346; VAA_00263.
GeneIDi10776629.
KEGGivan:VAA_00263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002284 Genomic DNA. Translation: AEH34346.1.
RefSeqiWP_013857914.1. NC_015633.1.

3D structure databases

ProteinModelPortaliF7YIR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi882102.VAA_00263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH34346; AEH34346; VAA_00263.
GeneIDi10776629.
KEGGivan:VAA_00263.

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
KOiK01775.
OMAiTHAKNQM.
OrthoDBiPOG091H022F.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciVANG882102:G12Y6-2851-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF7YIR2_VIBA7
AccessioniPrimary (citable) accession number: F7YIR2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 12, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.