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Protein

Alanine racemase

Gene

Mesop_1250

Organism
Mesorhizobium opportunistum (strain LMG 24607 / HAMBI 3007 / WSM2075)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Mesop_1250), Alanine racemase (Mesop_6198)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei53 – 531Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei152 – 1521SubstrateUniRule annotation
Active sitei274 – 2741Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei320 – 3201Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMOPP536019:GH56-1259-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotationSAAS annotation (EC:5.1.1.1UniRule annotationSAAS annotation)
Gene namesi
Ordered Locus Names:Mesop_1250Imported
OrganismiMesorhizobium opportunistum (strain LMG 24607 / HAMBI 3007 / WSM2075)Imported
Taxonomic identifieri536019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
ProteomesiUP000001623 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi536019.Mesop_1250.

Structurei

3D structure databases

ProteinModelPortaliF7YFI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7YFI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDASKRSLS GDTAGVSEAA AGAILTIDLG AIRENYRRLK AQLGGVRCAG
60 70 80 90 100
VVKADGYGLG ATQVASALMK DGCDTFFVAL LAEGISLRKA IGAGPDIYVL
110 120 130 140 150
NGLPPGSEPE AVAAGLCAVI NSGAQLKAWR AAAHGAGRQL PAAIQVDSGM
160 170 180 190 200
SRLGMAPAEV EAVVEDTGAF EGIDVRYVTS HLACADEPRH PANEQQRLAF
210 220 230 240 250
ERLRALLPAA PASLANSSGI FLGPRYHYDL ARPGAALYGI NPTPDATNPM
260 270 280 290 300
LPVVGLQAKV AQTRGIEKGT GVGYGHTYHA EGPRSLATIS FGYADGWLRR
310 320 330 340 350
SASAAWFEGV RLPFLGRVSM DSIILDVSAL SPGKLREGDL VELLGPAQSV
360 370
DDAAGHAGTI GYEILASLGT RFHRRYVGG
Length:379
Mass (Da):39,342
Last modified:September 21, 2011 - v1
Checksum:i1BAB425DE1386D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002279 Genomic DNA. Translation: AEH85733.1.
RefSeqiWP_013892470.1. NC_015675.1.
YP_004609827.1. NC_015675.1.

Genome annotation databases

EnsemblBacteriaiAEH85733; AEH85733; Mesop_1250.
KEGGimop:Mesop_1250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002279 Genomic DNA. Translation: AEH85733.1.
RefSeqiWP_013892470.1. NC_015675.1.
YP_004609827.1. NC_015675.1.

3D structure databases

ProteinModelPortaliF7YFI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi536019.Mesop_1250.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH85733; AEH85733; Mesop_1250.
KEGGimop:Mesop_1250.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciMOPP536019:GH56-1259-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LMG 24607 / HAMBI 3007 / WSM2075Imported.

Entry informationi

Entry nameiF7YFI8_MESOW
AccessioniPrimary (citable) accession number: F7YFI8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.