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Protein

Alanine racemase

Gene

Mesop_1250

Organism
Mesorhizobium opportunistum (strain LMG 24607 / HAMBI 3007 / WSM2075)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Mesop_6198), Alanine racemase (Mesop_1250)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei274Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei320Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMOPP536019:G1GPH-1277-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Mesop_1250Imported
OrganismiMesorhizobium opportunistum (strain LMG 24607 / HAMBI 3007 / WSM2075)Imported
Taxonomic identifieri536019 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000001623 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi536019.Mesop_1250

Structurei

3D structure databases

ProteinModelPortaliF7YFI8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 377Ala_racemase_CInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
KOiK01775
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

F7YFI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDASKRSLS GDTAGVSEAA AGAILTIDLG AIRENYRRLK AQLGGVRCAG
60 70 80 90 100
VVKADGYGLG ATQVASALMK DGCDTFFVAL LAEGISLRKA IGAGPDIYVL
110 120 130 140 150
NGLPPGSEPE AVAAGLCAVI NSGAQLKAWR AAAHGAGRQL PAAIQVDSGM
160 170 180 190 200
SRLGMAPAEV EAVVEDTGAF EGIDVRYVTS HLACADEPRH PANEQQRLAF
210 220 230 240 250
ERLRALLPAA PASLANSSGI FLGPRYHYDL ARPGAALYGI NPTPDATNPM
260 270 280 290 300
LPVVGLQAKV AQTRGIEKGT GVGYGHTYHA EGPRSLATIS FGYADGWLRR
310 320 330 340 350
SASAAWFEGV RLPFLGRVSM DSIILDVSAL SPGKLREGDL VELLGPAQSV
360 370
DDAAGHAGTI GYEILASLGT RFHRRYVGG
Length:379
Mass (Da):39,342
Last modified:September 21, 2011 - v1
Checksum:i1BAB425DE1386D64
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002279 Genomic DNA Translation: AEH85733.1
RefSeqiWP_013892470.1, NC_015675.1

Genome annotation databases

EnsemblBacteriaiAEH85733; AEH85733; Mesop_1250
KEGGimop:Mesop_1250

Similar proteinsi

Entry informationi

Entry nameiF7YFI8_MESOW
AccessioniPrimary (citable) accession number: F7YFI8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 23, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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