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Protein

Elongation factor Tu

Gene

tufB

Organism
Midichloria mitochondrii (strain IricVA)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi76 – 805GTPUniRule annotation
Nucleotide bindingi131 – 1344GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotation, HydrolaseImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMIT696127:GI3H-560-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufBImported
Synonyms:tufUniRule annotation
Ordered Locus Names:midi_00560Imported
OrganismiMidichloria mitochondrii (strain IricVA)Imported
Taxonomic identifieri696127 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesCandidatus MidichloriaceaeCandidatus Midichloria
ProteomesiUP000006639 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

KOiK02358.
OMAiDEGGRHN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7XW13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEKFVRNK PHVNIGTIGH VDHGKTSLTA ALTKMFGRYV KYDEIDKAPE
60 70 80 90 100
EKARGITINS AHVEYETENR HYAHVDCPGH ADYVKNMITG AAQMDGAILV
110 120 130 140 150
VSAADGPMPQ TREHILLARQ VGVPALVVFL NKVDMVDDPE LLELVEMEVR
160 170 180 190 200
DLLNQYGFPG DQIPVIKGSA LMALEGKNPA LGEEAIKELM KQVDEYIPLP
210 220 230 240 250
TRSVDKPFLM PVEDVFSISG RGTVATGRVE QGVVKVGEEI EIVGLKAQSS
260 270 280 290 300
KTTCTGVEMF RRLLDQGEAG DNVGLLLRGI ERDQIERGQV LAKPGTIKPH
310 320 330 340 350
KKFRAEVYIL KKEEGGRHTP FVSNYRPQFY FRTTDVTGTI NLKAGVEMVM
360 370 380 390
PGDNTEIMVE LISPIAMDKG LKFAIREGGR TVGAGVVAEI IE
Length:392
Mass (Da):43,088
Last modified:September 21, 2011 - v1
Checksum:iADCED9395F4EC06F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002130 Genomic DNA. Translation: AEI88862.1.
RefSeqiWP_013951074.1. NC_015722.1.
YP_004679548.1. NC_015722.1.

Genome annotation databases

EnsemblBacteriaiAEI88862; AEI88862; midi_00560.
KEGGimmn:midi_00560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002130 Genomic DNA. Translation: AEI88862.1.
RefSeqiWP_013951074.1. NC_015722.1.
YP_004679548.1. NC_015722.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI88862; AEI88862; midi_00560.
KEGGimmn:midi_00560.

Phylogenomic databases

KOiK02358.
OMAiDEGGRHN.

Enzyme and pathway databases

BioCyciMMIT696127:GI3H-560-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Phylogenomic evidence for the presence of a flagellum and cbb3 oxidase in the free-living mitochondrial ancestor."
    Sassera D., Lo N., Epis S., D'Auria G., Montagna M., Comandatore F., Horner D., Pereto J., Luciano A.M., Franciosi F., Ferri E., Crotti E., Bazzocchi C., Daffonchio D., Sacchi L., Moya A., Latorre A., Bandi C.
    Mol. Biol. Evol. 28:3285-3296(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IricVAImported.

Entry informationi

Entry nameiF7XW13_MIDMI
AccessioniPrimary (citable) accession number: F7XW13
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 1, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.