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F7XUC3

- F7XUC3_MIDMI

UniProt

F7XUC3 - F7XUC3_MIDMI

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Protein
D-alanine--D-alanine ligase
Gene
ddlA, ddl, midi_01206
Organism
Midichloria mitochondrii (strain IricVA)
Status
Unreviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotations

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi252 – 2521Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi268 – 2681Magnesium or manganese 1 By similarityUniRule annotation
Metal bindingi268 – 2681Magnesium or manganese 2 By similarityUniRule annotation
Metal bindingi270 – 2701Magnesium or manganese 2 By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi130 – 18455ATP By similarityUniRule annotation
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Cell cycle, Cell divisionSAAS annotations, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotations, Peptidoglycan synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, ManganeseUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMIT696127:GI3H-1205-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddlAImported
Synonyms:ddlUniRule annotation
Ordered Locus Names:midi_01206Imported
OrganismiMidichloria mitochondrii (strain IricVA)Imported
Taxonomic identifieri696127 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesCandidatus MidichloriaceaeCandidatus Midichloria
ProteomesiUP000006639: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotations, CytoplasmUniRule annotationSAAS annotations, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 301201ATP-grasp By similarityUniRule annotation
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

KOiK01921.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005548. Cell_div_FtsQ/DivIB.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR013685. POTRA_FtsQ_type.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
PF03799. FtsQ. 1 hit.
PF08478. POTRA_1. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7XUC3-1 [UniParc]FASTAAdd to Basket

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MNKHIVLLVG GVSREREVSQ ISGESVRNAL LSLGYRVTVV DPSENLASEL    50
IKLRPDIVFN CLHGTFGEGG SIPGLLELLR IPYTHSGVTA SAIAMDKILT 100
KKMAQTCDIN TPKYVKIEKS ALFTMLEKGE DPMPKPYVIK AVQQGSSIGI 150
YLVIDENSDK PKKAEWTFGE QILVEEYIPG QELSVAVLND KALGVLELRP 200
KTNFYDYTAK YSDGVTEHVH PAEIPQEVYL EAMKRAEEMH KALGCRTVSR 250
SDFRYNNIGS ADGLFFLEIN THPGFTNLSI VPDIASRRGI SFEQIIEQLL 300
KDAKMRNNAV KIAKYTYLDT DVHYGKQISS LLQPAREKPF KKIIRVYILF 350
LLGVAAIFYI LTKLCTNEVD QFVDKLINKT VISELNICGN IQVSKEEIIN 400
TLDLSLPLEV SYINASHIKE ELLKNPLIKD VEVKINLPNI LSLLVTERQP 450
FALWFDQKQF HLIDEEGFIV KACVEFQEKE NKYIIAAGTD SNNQLQNLLD 500
ELKGYSISKK LFAVQLISNR RWNILLKNGL IVKLPENNVK EALVALDLVL 550
ENYSPSKPFN IIDLRLAPGK VYAVF 575
Length:575
Mass (Da):64,744
Last modified:September 21, 2011 - v1
Checksum:i8635E4385156424D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002130 Genomic DNA. Translation: AEI89482.1.
RefSeqiWP_013951674.1. NC_015722.1.
YP_004680168.1. NC_015722.1.

Genome annotation databases

EnsemblBacteriaiAEI89482; AEI89482; midi_01206.
GeneIDi10914928.
KEGGimmn:midi_01206.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002130 Genomic DNA. Translation: AEI89482.1 .
RefSeqi WP_013951674.1. NC_015722.1.
YP_004680168.1. NC_015722.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEI89482 ; AEI89482 ; midi_01206 .
GeneIDi 10914928.
KEGGi mmn:midi_01206.

Phylogenomic databases

KOi K01921.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci MMIT696127:GI3H-1205-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005548. Cell_div_FtsQ/DivIB.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR013685. POTRA_FtsQ_type.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
PF03799. FtsQ. 1 hit.
PF08478. POTRA_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenomic evidence for the presence of a flagellum and cbb(3) oxidase in the free-living mitochondrial ancestor."
    Sassera D., Lo N., Epis S., D'Auria G., Montagna M., Comandatore F., Horner D., Pereto J., Luciano A.M., Franciosi F., Ferri E., Crotti E., Bazzocchi C., Daffonchio D., Sacchi L., Moya A., Latorre A., Bandi C.
    Mol. Biol. Evol. 28:3285-3296(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IricVAImported.

Entry informationi

Entry nameiF7XUC3_MIDMI
AccessioniPrimary (citable) accession number: F7XUC3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3