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F7XUC3

- F7XUC3_MIDMI

UniProt

F7XUC3 - F7XUC3_MIDMI

Protein

D-alanine--D-alanine ligase

Gene

ddlA

Organism
Midichloria mitochondrii (strain IricVA)
Status
Unreviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Cell wall formation.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi252 – 2521Magnesium or manganese 1UniRule annotation
    Metal bindingi268 – 2681Magnesium or manganese 1UniRule annotation
    Metal bindingi268 – 2681Magnesium or manganese 2UniRule annotation
    Metal bindingi270 – 2701Magnesium or manganese 2UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi130 – 18455ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionSAAS annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMIT696127:GI3H-1205-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
    Alternative name(s):
    D-Ala-D-Ala ligaseUniRule annotation
    D-alanylalanine synthetaseUniRule annotation
    Gene namesi
    Name:ddlAImported
    Synonyms:ddlUniRule annotation
    Ordered Locus Names:midi_01206Imported
    OrganismiMidichloria mitochondrii (strain IricVA)Imported
    Taxonomic identifieri696127 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesCandidatus MidichloriaceaeCandidatus Midichloria
    ProteomesiUP000006639: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, CytoplasmUniRule annotationSAAS annotation, Membrane

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 301201ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation
    Contains ATP-grasp domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    KOiK01921.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPiMF_00047. Dala_Dala_lig.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005548. Cell_div_FtsQ/DivIB.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR013685. POTRA_FtsQ_type.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR23132. PTHR23132. 1 hit.
    PfamiPF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 2 hits.
    PF03799. FtsQ. 1 hit.
    PF08478. POTRA_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7XUC3-1 [UniParc]FASTAAdd to Basket

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    MNKHIVLLVG GVSREREVSQ ISGESVRNAL LSLGYRVTVV DPSENLASEL    50
    IKLRPDIVFN CLHGTFGEGG SIPGLLELLR IPYTHSGVTA SAIAMDKILT 100
    KKMAQTCDIN TPKYVKIEKS ALFTMLEKGE DPMPKPYVIK AVQQGSSIGI 150
    YLVIDENSDK PKKAEWTFGE QILVEEYIPG QELSVAVLND KALGVLELRP 200
    KTNFYDYTAK YSDGVTEHVH PAEIPQEVYL EAMKRAEEMH KALGCRTVSR 250
    SDFRYNNIGS ADGLFFLEIN THPGFTNLSI VPDIASRRGI SFEQIIEQLL 300
    KDAKMRNNAV KIAKYTYLDT DVHYGKQISS LLQPAREKPF KKIIRVYILF 350
    LLGVAAIFYI LTKLCTNEVD QFVDKLINKT VISELNICGN IQVSKEEIIN 400
    TLDLSLPLEV SYINASHIKE ELLKNPLIKD VEVKINLPNI LSLLVTERQP 450
    FALWFDQKQF HLIDEEGFIV KACVEFQEKE NKYIIAAGTD SNNQLQNLLD 500
    ELKGYSISKK LFAVQLISNR RWNILLKNGL IVKLPENNVK EALVALDLVL 550
    ENYSPSKPFN IIDLRLAPGK VYAVF 575
    Length:575
    Mass (Da):64,744
    Last modified:September 21, 2011 - v1
    Checksum:i8635E4385156424D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002130 Genomic DNA. Translation: AEI89482.1.
    RefSeqiWP_013951674.1. NC_015722.1.
    YP_004680168.1. NC_015722.1.

    Genome annotation databases

    EnsemblBacteriaiAEI89482; AEI89482; midi_01206.
    GeneIDi10914928.
    KEGGimmn:midi_01206.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002130 Genomic DNA. Translation: AEI89482.1 .
    RefSeqi WP_013951674.1. NC_015722.1.
    YP_004680168.1. NC_015722.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEI89482 ; AEI89482 ; midi_01206 .
    GeneIDi 10914928.
    KEGGi mmn:midi_01206.

    Phylogenomic databases

    KOi K01921.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci MMIT696127:GI3H-1205-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    HAMAPi MF_00047. Dala_Dala_lig.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR005548. Cell_div_FtsQ/DivIB.
    IPR005905. D_ala_D_ala.
    IPR011095. Dala_Dala_lig_C.
    IPR011127. Dala_Dala_lig_N.
    IPR013685. POTRA_FtsQ_type.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR23132. PTHR23132. 1 hit.
    Pfami PF07478. Dala_Dala_lig_C. 1 hit.
    PF01820. Dala_Dala_lig_N. 2 hits.
    PF03799. FtsQ. 1 hit.
    PF08478. POTRA_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenomic evidence for the presence of a flagellum and cbb3 oxidase in the free-living mitochondrial ancestor."
      Sassera D., Lo N., Epis S., D'Auria G., Montagna M., Comandatore F., Horner D., Pereto J., Luciano A.M., Franciosi F., Ferri E., Crotti E., Bazzocchi C., Daffonchio D., Sacchi L., Moya A., Latorre A., Bandi C.
      Mol. Biol. Evol. 28:3285-3296(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IricVAImported.

    Entry informationi

    Entry nameiF7XUC3_MIDMI
    AccessioniPrimary (citable) accession number: F7XUC3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3