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F7XTA8

- F7XTA8_TREPU

UniProt

F7XTA8 - F7XTA8_TREPU

Protein

Alanine racemase

Gene

alr

Organism
Treponema paraluiscuniculi (strain Cuniculi A)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei33 – 331Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei134 – 1341SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciTPAR545776:GJC6-703-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:TPCCA_0681Imported
    OrganismiTreponema paraluiscuniculi (strain Cuniculi A)Imported
    Taxonomic identifieri545776 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008317: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF7XTA8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7XTA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MACNQALIHL ANLRHNLGEI MSRTRARVCL PVKADAYGHG ACDVAQAALS    50
    CGVHSFAVAC VQEASQLRAA GVRAPILCLS TPTAEEISSL IEHRVHTVIS 100
    ERAHIALIAR ALRQSADTGA TCGVHVKIDT GMGRIGCAPD EACALVQMVC 150
    ATPGLHLEGV CTHFSVADSL RAENLQYTEM QRAHFMHCVQ YIRKSGISIP 200
    LVHAANSAAL LCHPRAHFDM VRPGLLAYGY APESVHPAVR SVFLPVMELV 250
    TRVRAIKKIP AGAYVSYQRL WRAHTETHVG ILPIGYADGV MRALSPGLQV 300
    CIGGKWYPVV GAICMDQCVV DLGTPLRVTV GDRVTLFGPQ DAGGPGQGAD 350
    VLASHAGTIP YELLCAIGKR VERVYIR 377
    Length:377
    Mass (Da):40,353
    Last modified:September 21, 2011 - v1
    Checksum:i0D9416E5B86B6BCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002103 Genomic DNA. Translation: AEH40611.1.
    RefSeqiWP_013945291.1. NC_015714.1.
    YP_004673402.1. NC_015714.1.

    Genome annotation databases

    EnsemblBacteriaiAEH40611; AEH40611; TPCCA_0681.
    GeneIDi10884372.
    KEGGitpl:TPCCA_0681.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002103 Genomic DNA. Translation: AEH40611.1 .
    RefSeqi WP_013945291.1. NC_015714.1.
    YP_004673402.1. NC_015714.1.

    3D structure databases

    ProteinModelPortali F7XTA8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH40611 ; AEH40611 ; TPCCA_0681 .
    GeneIDi 10884372.
    KEGGi tpl:TPCCA_0681.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci TPAR545776:GJC6-703-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay."
      Smajs D., Zobanikova M., Strouhal M., Cejkova D., Dugan-Rocha S., Pospisilova P., Norris S.J., Albert T., Qin X., Hallsworth-Pepin K., Buhay C., Muzny D.M., Chen L., Gibbs R.A., Weinstock G.M.
      PLoS ONE 6:E20415-E20415(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Cuniculi AImported.

    Entry informationi

    Entry nameiF7XTA8_TREPU
    AccessioniPrimary (citable) accession number: F7XTA8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3