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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Treponema paraluiscuniculi (strain Cuniculi A)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi125ZincUniRule annotation1
Metal bindingi127ZincUniRule annotation1
Metal bindingi152ZincUniRule annotation1
Metal bindingi154ZincUniRule annotation1
Binding sitei273ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTPAR545776:G1GYH-691-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotationImported
Ordered Locus Names:TPCCA_0673Imported
OrganismiTreponema paraluiscuniculi (strain Cuniculi A)Imported
Taxonomic identifieri545776 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008317 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 339tRNA-synt_1cInterPro annotationAdd BLAST338

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi270 – 274"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK01885.
OMAiAYYAFDT.

Family and domain databases

CDDicd00808. GluRS_core. 1 hit.
Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00022. Glu_tRNA_synth_type1. 1 hit.
InterProiView protein in InterPro
IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR033910. GluRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 2 hits.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

F7XTA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVRVRYAPS PTGLQHIGGI RTALFNFLFA RAHAGVFVLR VEDTDRSRCT
60 70 80 90 100
AAFEQNLYDT LRWLGVSWDE GGGCPETAVK QGARGDGRSV AHAGGAYGPY
110 120 130 140 150
TQSARTDLYR AQVARLVETG QAYYCFCDAS RLERVRKIRT LNRMPPGYDR
160 170 180 190 200
HCRELLPEEV RECLASGVPH VIRFKVPLEG STHFRDALLG DIEWQNEEIN
210 220 230 240 250
PDPILLKSDG FPTYHLANVV DDHAMRITHV LRAQEWVPST PLHLLLYRAF
260 270 280 290 300
GWQPPLFCHL PMVMGADGHK LSKRHGATSC DEFRNAGYLP EALLNYVAML
310 320 330 340 350
GCSYGEGQDL FTREQLCAHF SLSRLNKSPA VFDYKKLAWF NGQYIRAKSD
360 370 380 390 400
EQLCALVWPF IANAGVCGHI PADVEAEAVR TRRFADEAPC APTEAQRSML
410 420 430 440 450
MRVIPLIKER LRFLTDAPEL VRCFFQEPSL PEQGVFVPKR LDVAQVRAVL
460 470 480 490 500
VRARGLVHEI VSASEPDVEV LLRAEAEKFG IKLGDFLMPI RVALTGATVS
510 520 530
APLVGTIRIL GASRSCARIE HVIRERFSDD SQGVGGG
Length:537
Mass (Da):59,912
Last modified:September 21, 2011 - v1
Checksum:i9643E4DA12DAE029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002103 Genomic DNA. Translation: AEH40603.1.
RefSeqiWP_013945285.1. NC_015714.1.

Genome annotation databases

EnsemblBacteriaiAEH40603; AEH40603; TPCCA_0673.
KEGGitpl:TPCCA_0673.
PATRICifig|545776.3.peg.673.

Similar proteinsi

Entry informationi

Entry nameiF7XTA0_TREPU
AccessioniPrimary (citable) accession number: F7XTA0
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported