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F7XT97 (F7XT97_TREPU) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AEH40600.1
Ordered Locus Names:TPCCA_0670 EMBL AEH40600.1
OrganismTreponema paraluiscuniculi (strain Cuniculi A) [Complete proteome] [HAMAP] EMBL AEH40600.1
Taxonomic identifier545776 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain141 – 347207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding174 – 22956ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3011Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3141Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3161Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F7XT97 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 666ED19ECD0B2CE4

FASTA39642,794
        10         20         30         40         50         60 
MVHVTLLYGG RSAEHDVSVR SARFVARTLC LQHTVMLIGI TRRGVWYAQP ACALEQLCTG 

        70         80         90        100        110        120 
TVALSIQEDE KRRVCLVPGG GTAGAFVIAG MPCVTDVVFP VLHGSYGEDG TVQGLLEMLQ 

       130        140        150        160        170        180 
VPYVGCGVCA SALAMDKVKA KMLWQAAGLP VLPFVFFRKD TWRMHMQELV AQLETRLGYP 

       190        200        210        220        230        240 
LFVKPAQAGS SVGASPVQTR APLIPAIEAA FQWDEVVLVE RYVRAREIEC ALSGNGPYTV 

       250        260        270        280        290        300 
HGAGEVIAQG AFYDYEEKYA DASVARVLVT APLETAQYEQ ITTLALRAYE ALGLTGLARV 

       310        320        330        340        350        360 
DFFLLETGEV YANEVNTMPG FTSISLFPQI CQAAGVAPQD LMAQLLSCAR ERFAARAALS 

       370        380        390 
TDLHAHVCAP SVTAAHDPDA QEDDWDQRDS NPLPTA 

« Hide

References

[1]"Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A: the loss of infectivity to humans is associated with genome decay."
Smajs D., Zobanikova M., Strouhal M., Cejkova D., Dugan-Rocha S., Pospisilova P., Norris S.J., Albert T., Qin X., Hallsworth-Pepin K., Buhay C., Muzny D.M., Chen L., Gibbs R.A., Weinstock G.M.
PLoS ONE 6:E20415-E20415(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Cuniculi A EMBL AEH40600.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002103 Genomic DNA. Translation: AEH40600.1.
RefSeqYP_004673391.1. NC_015714.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH40600; AEH40600; TPCCA_0670.
GeneID10884360.
KEGGtpl:TPCCA_0670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycTPAR545776:GJC6-691-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF7XT97_TREPU
AccessionPrimary (citable) accession number: F7XT97
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 16, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)