ID   F7XSV6_TREPU            Unreviewed;       444 AA.
AC   F7XSV6;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   SubName: Full=Hexokinase {ECO:0000313|EMBL:AEH40442.1};
DE            EC=2.7.1.1 {ECO:0000313|EMBL:AEH40442.1};
GN   OrderedLocusNames=TPCCA_0505 {ECO:0000313|EMBL:AEH40442.1};
OS   Treponema paraluiscuniculi (strain Cuniculi A).
OC   Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Treponemataceae;
OC   Treponema.
OX   NCBI_TaxID=545776 {ECO:0000313|EMBL:AEH40442.1, ECO:0000313|Proteomes:UP000008317};
RN   [1] {ECO:0000313|EMBL:AEH40442.1, ECO:0000313|Proteomes:UP000008317}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Cuniculi A {ECO:0000313|EMBL:AEH40442.1,
RC   ECO:0000313|Proteomes:UP000008317};
RX   PubMed=21655244; DOI=10.1371/journal.pone.0020415;
RA   Smajs D., Zobanikova M., Strouhal M., Cejkova D., Dugan-Rocha S.,
RA   Pospisilova P., Norris S.J., Albert T., Qin X., Hallsworth-Pepin K.,
RA   Buhay C., Muzny D.M., Chen L., Gibbs R.A., Weinstock G.M.;
RT   "Complete genome sequence of Treponema paraluiscuniculi, strain Cuniculi A:
RT   the loss of infectivity to humans is associated with genome decay.";
RL   PLoS ONE 6:E20415-E20415(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001397};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC         Evidence={ECO:0000256|ARBA:ARBA00001397};
CC   -!- PATHWAY: Carbohydrate degradation. {ECO:0000256|ARBA:ARBA00004921}.
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|ARBA:ARBA00009225}.
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DR   EMBL; CP002103; AEH40442.1; -; Genomic_DNA.
DR   RefSeq; WP_013945145.1; NC_015714.1.
DR   AlphaFoldDB; F7XSV6; -.
DR   KEGG; tpl:TPCCA_0505; -.
DR   PATRIC; fig|545776.3.peg.508; -.
DR   HOGENOM; CLU_014393_5_3_12; -.
DR   UniPathway; UPA00109; UER00180.
DR   Proteomes; UP000008317; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IEA:RHEA.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.40.367.20; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; HEXOKINASE; 1.
DR   PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PRINTS; PR00475; HEXOKINASE.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEH40442.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AEH40442.1}.
FT   DOMAIN          19..205
FT                   /note="Hexokinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00349"
FT   DOMAIN          219..440
FT                   /note="Hexokinase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03727"
SQ   SEQUENCE   444 AA;  47859 MW;  58777811012AD67E CRC64;
     MDQHTRTRDL VSAFFGRFHF DVQGPSVRTV VDVLRADMVR GLEEEAQLPP RMGSALAMIP
     TWVAPPRVSP CNRRVIVIDA GGTNFRSCLV RFGDSGTPHI ENLEKRPMPG TTREYSRTEF
     FGEIADNLAR LKGAADCIGF CFSYPIRIRP DGDGEVIQFA KEIKAAEVIG TCVGAALTEA
     LSARNWPELR SLKMLNDATS ALLAGFFAAP EGCSFSSYVG FILGTGMNSA YLEPDPIPKI
     PAHHTPQVVV CESGKSNKVP RSVFDELFTQ TTAEPDIAHL EKMSSGTYLG PLASVVVRLA
     AQEGLFSHAV HAALSTVSFT LVDMDRFLFA PSVSTTTLGA LLAPGTDTDR EILFLLLDAV
     VARAARIAAG VIAASVLKSG AGYDPLRPVC VLAEGTTFQR TYRLRTRVTS HLQAFLTEER
     GVYFDIISLE NAVTLGSALG GLSS
//