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F7XQS2

- HPRT_METZD

UniProt

F7XQS2 - HPRT_METZD

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Protein
Hypoxanthine/guanine phosphoribosyltransferase
Gene
hpt, Mzhil_1841
Organism
Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciMZHI679901:GHPZ-1902-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:Mzhil_1841
OrganismiMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Taxonomic identifieri679901 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosalsum
ProteomesiUP000006622: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation
PRO_0000415479Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF7XQS2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7XQS2-1 [UniParc]FASTAAdd to Basket

« Hide

MLEQLYDSLV NAPVVKRGDY SYFIHPVSDG VPLLEPSLLE EISECILCYA    50
DMDVDRIVTV EAMGIPVATC LSLKTGIPLS IVRKRKYDLA GEIELSQSTG 100
YSKGKLYVNG ISEGDRVLIV DDVISTGGTL LVLVKALEDA GIKISDVVAV 150
IERGTGSNDL RDAGIDVKTL VRVEVDDDRV VVEEVYSDNE 190
Length:190
Mass (Da):20,650
Last modified:September 21, 2011 - v1
Checksum:iCE4902299DE89F7B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002101 Genomic DNA. Translation: AEH61676.1.
RefSeqiYP_004616895.1. NC_015676.1.

Genome annotation databases

EnsemblBacteriaiAEH61676; AEH61676; Mzhil_1841.
GeneIDi10823485.
KEGGimzh:Mzhil_1841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002101 Genomic DNA. Translation: AEH61676.1 .
RefSeqi YP_004616895.1. NC_015676.1.

3D structure databases

ProteinModelPortali F7XQS2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH61676 ; AEH61676 ; Mzhil_1841 .
GeneIDi 10823485.
KEGGi mzh:Mzhil_1841.

Phylogenomic databases

KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci MZHI679901:GHPZ-1902-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4017 / NBRC 107636 / OCM 62 / WeN5.

Entry informationi

Entry nameiHPRT_METZD
AccessioniPrimary (citable) accession number: F7XQS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: September 21, 2011
Last modified: July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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