ID   F7XQJ9_METZD            Unreviewed;       340 AA.
AC   F7XQJ9;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   SubName: Full=Isocitrate dehydrogenase (NAD(+)) {ECO:0000313|EMBL:AEH60501.1};
DE            EC=1.1.1.41 {ECO:0000313|EMBL:AEH60501.1};
GN   OrderedLocusNames=Mzhil_0634 {ECO:0000313|EMBL:AEH60501.1};
OS   Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5)
OS   (Methanohalophilus zhilinae).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosalsum.
OX   NCBI_TaxID=679901 {ECO:0000313|EMBL:AEH60501.1, ECO:0000313|Proteomes:UP000006622};
RN   [1] {ECO:0000313|Proteomes:UP000006622}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 4017 / NBRC 107636 / OCM 62 / WeN5
RC   {ECO:0000313|Proteomes:UP000006622};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K.,
RA   Ovchinnikova G., Daligault H., Detter J.C., Han C., Tapia R., Larimer F.,
RA   Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T.,
RA   Wu D., Spring S., Schueler E., Brambilla E., Klenk H.-P., Eisen J.A.;
RT   "The complete genome of Methanosalsum zhilinae DSM 4017.";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC       dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
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DR   EMBL; CP002101; AEH60501.1; -; Genomic_DNA.
DR   RefSeq; WP_013897940.1; NC_015676.1.
DR   AlphaFoldDB; F7XQJ9; -.
DR   STRING; 679901.Mzhil_0634; -.
DR   GeneID; 10822245; -.
DR   KEGG; mzh:Mzhil_0634; -.
DR   HOGENOM; CLU_031953_0_1_2; -.
DR   OrthoDB; 6813at2157; -.
DR   Proteomes; UP000006622; Chromosome.
DR   GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR   InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR   PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR   PANTHER; PTHR11835:SF77; ISOCITRATE_ISOPROPYLMALATE DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00180; Iso_dh; 1.
DR   SMART; SM01329; Iso_dh; 1.
DR   SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000313|EMBL:AEH60501.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006622}.
FT   DOMAIN          4..333
FT                   /note="Isopropylmalate dehydrogenase-like"
FT                   /evidence="ECO:0000259|SMART:SM01329"
SQ   SEQUENCE   340 AA;  37372 MW;  709EA97EAE445B40 CRC64;
     MSKTAAVIKG DGVGPELVDA MLDVVNSAGT DVEFITCEAG ESWWKQHGGN SLIPDETWEV
     IENSDACFKG PTTTPGGAGS PKSVAVSIRQ KYNLYANVRP IKTFPNTNPP LGDVDFVCVR
     EGTEGMYIGE EIKLTDDVYI AIRKITRTAS RNIARFSFEE AKRRNYEAVV AIHKSNILKQ
     TCGTFVEEVN YVGEQYPDIE VWEYHIDNIA QQLIKNPQLF NNKILLSTNL FMDVISEECS
     ALVGSIGLIY SANIGDNYAM FEPAHGSAPK YAGKDKVNPV ATVLAGAWML DYLGEEKQAA
     AIFEATEKVI SEGKHVTYDL GGNAKLSEMT GEIIKYIEEF
//