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F7XL21

- F7XL21_METZD

UniProt

F7XL21 - F7XL21_METZD

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Protein
DNA ligase
Gene
lig, Mzhil_0867
Organism
Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541ATP By similarityUniRule annotation
Active sitei256 – 2561N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei261 – 2611ATP By similarityUniRule annotation
Binding sitei276 – 2761ATP By similarityUniRule annotation
Binding sitei306 – 3061ATP By similarityUniRule annotation
Binding sitei346 – 3461ATP By similarityUniRule annotation
Binding sitei421 – 4211ATP By similarityUniRule annotation
Binding sitei427 – 4271ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMZHI679901:GHPZ-902-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mzhil_0867Imported
OrganismiMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)Imported
Taxonomic identifieri679901 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosalsum
ProteomesiUP000006622: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF7XL21.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7XL21-1 [UniParc]FASTAAdd to Basket

« Hide

MTAFKEFAHV CSQIENTSSS LEITDMVAEF FRIVDTEELP VVIHFIMGEV    50
FPAWSEEELG IGKGLYYTSL SKVSGLSVDE IKEIVRKTGD IGKTTIEVMK 100
NKSGDQVTFS VFFDDNTQLS IIDVYEALKK IAAINGKGSQ NIKMKNLQYI 150
FSKASPQESQ YMARLVLEEL RIGVGEGIVR DAIALAFDVP AESIERGFML 200
TNDMGAVGLA AKKGGIEEVE KLNMELNRPI KLMLAQVTPS IKTAIEEMEE 250
AAIEWKFDGA RLQVHKDKDK VSIYSRKLEN ITNSLPDVVS AVKEYVNADT 300
AILDGEAFAV DENGKPKPFQ EILKRLRRKY DIEITTRDIP LTVKFFDIMY 350
LNGDYLIDLS LIERRRLLGE CVRNSNSITV DQQVVTDDPE IGEKIYSEAI 400
RAGHEGIMIK NPQSPYTPGK RGKNWLKKKP VMETLDLVVI GGEWGYGRRT 450
NFIGSYTLSC YDPDSGNFLP IGKVGTGITD ENLVELTGLF SDLIVVESGR 500
DLEFKPEIVF EVAFEEIQKS TNYESGYALR FPRLVSIRDD KSPHEADTIS 550
RVDEIYRSQR K 561
Length:561
Mass (Da):63,050
Last modified:September 21, 2011 - v1
Checksum:iD1AF3543A6495D18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002101 Genomic DNA. Translation: AEH60729.1.
RefSeqiYP_004615948.1. NC_015676.1.

Genome annotation databases

EnsemblBacteriaiAEH60729; AEH60729; Mzhil_0867.
GeneIDi10822488.
KEGGimzh:Mzhil_0867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002101 Genomic DNA. Translation: AEH60729.1 .
RefSeqi YP_004615948.1. NC_015676.1.

3D structure databases

ProteinModelPortali F7XL21.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH60729 ; AEH60729 ; Mzhil_0867 .
GeneIDi 10822488.
KEGGi mzh:Mzhil_0867.

Phylogenomic databases

KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MZHI679901:GHPZ-902-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4017 / NBRC 107636 / OCM 62 / WeN5.

Entry informationi

Entry nameiF7XL21_METZD
AccessioniPrimary (citable) accession number: F7XL21
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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