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F7XL21 (F7XL21_METZD) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase HAMAP-Rule MF_00407
EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Mzhil_0867
OrganismMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae) [Complete proteome] [HAMAP] EMBL AEH60729.1
Taxonomic identifier679901 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosalsum ›

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2561N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2541ATP By similarity HAMAP-Rule MF_00407
Binding site2611ATP By similarity HAMAP-Rule MF_00407
Binding site2761ATP By similarity HAMAP-Rule MF_00407
Binding site3061ATP By similarity HAMAP-Rule MF_00407
Binding site3461ATP By similarity HAMAP-Rule MF_00407
Binding site4211ATP By similarity HAMAP-Rule MF_00407
Binding site4271ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
F7XL21 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: D1AF3543A6495D18

FASTA56163,050
        10         20         30         40         50         60 
MTAFKEFAHV CSQIENTSSS LEITDMVAEF FRIVDTEELP VVIHFIMGEV FPAWSEEELG 

        70         80         90        100        110        120 
IGKGLYYTSL SKVSGLSVDE IKEIVRKTGD IGKTTIEVMK NKSGDQVTFS VFFDDNTQLS 

       130        140        150        160        170        180 
IIDVYEALKK IAAINGKGSQ NIKMKNLQYI FSKASPQESQ YMARLVLEEL RIGVGEGIVR 

       190        200        210        220        230        240 
DAIALAFDVP AESIERGFML TNDMGAVGLA AKKGGIEEVE KLNMELNRPI KLMLAQVTPS 

       250        260        270        280        290        300 
IKTAIEEMEE AAIEWKFDGA RLQVHKDKDK VSIYSRKLEN ITNSLPDVVS AVKEYVNADT 

       310        320        330        340        350        360 
AILDGEAFAV DENGKPKPFQ EILKRLRRKY DIEITTRDIP LTVKFFDIMY LNGDYLIDLS 

       370        380        390        400        410        420 
LIERRRLLGE CVRNSNSITV DQQVVTDDPE IGEKIYSEAI RAGHEGIMIK NPQSPYTPGK 

       430        440        450        460        470        480 
RGKNWLKKKP VMETLDLVVI GGEWGYGRRT NFIGSYTLSC YDPDSGNFLP IGKVGTGITD 

       490        500        510        520        530        540 
ENLVELTGLF SDLIVVESGR DLEFKPEIVF EVAFEEIQKS TNYESGYALR FPRLVSIRDD 

       550        560 
KSPHEADTIS RVDEIYRSQR K

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References

[1]"The complete genome of Methanosalsum zhilinae DSM 4017."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ovchinnikova G., Daligault H., Detter J.C., Han C., Tapia R., Larimer F., Land M. expand/collapse author list , Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S., Schueler E., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 4017 / NBRC 107636 / OCM 62 / WeN5.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002101 Genomic DNA. Translation: AEH60729.1.
RefSeqYP_004615948.1. NC_015676.1.

3D structure databases

ProteinModelPortalF7XL21.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH60729; AEH60729; Mzhil_0867.
GeneID10822488.
KEGGmzh:Mzhil_0867.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.

Enzyme and pathway databases

BioCycMZHI679901:GHPZ-902-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF7XL21_METZD
AccessionPrimary (citable) accession number: F7XL21
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 29, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info