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F7XL21

- F7XL21_METZD

UniProt

F7XL21 - F7XL21_METZD

Protein

DNA ligase

Gene

lig

Organism
Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei254 – 2541ATPUniRule annotation
    Active sitei256 – 2561N6-AMP-lysine intermediateUniRule annotation
    Binding sitei261 – 2611ATPUniRule annotation
    Binding sitei276 – 2761ATPUniRule annotation
    Binding sitei306 – 3061ATPUniRule annotation
    Binding sitei346 – 3461ATPUniRule annotation
    Binding sitei421 – 4211ATPUniRule annotation
    Binding sitei427 – 4271ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA recombination Source: UniProtKB-HAMAP
    4. DNA repair Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMZHI679901:GHPZ-902-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mzhil_0867Imported
    OrganismiMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)Imported
    Taxonomic identifieri679901 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosalsum
    ProteomesiUP000006622: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF7XL21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7XL21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAFKEFAHV CSQIENTSSS LEITDMVAEF FRIVDTEELP VVIHFIMGEV    50
    FPAWSEEELG IGKGLYYTSL SKVSGLSVDE IKEIVRKTGD IGKTTIEVMK 100
    NKSGDQVTFS VFFDDNTQLS IIDVYEALKK IAAINGKGSQ NIKMKNLQYI 150
    FSKASPQESQ YMARLVLEEL RIGVGEGIVR DAIALAFDVP AESIERGFML 200
    TNDMGAVGLA AKKGGIEEVE KLNMELNRPI KLMLAQVTPS IKTAIEEMEE 250
    AAIEWKFDGA RLQVHKDKDK VSIYSRKLEN ITNSLPDVVS AVKEYVNADT 300
    AILDGEAFAV DENGKPKPFQ EILKRLRRKY DIEITTRDIP LTVKFFDIMY 350
    LNGDYLIDLS LIERRRLLGE CVRNSNSITV DQQVVTDDPE IGEKIYSEAI 400
    RAGHEGIMIK NPQSPYTPGK RGKNWLKKKP VMETLDLVVI GGEWGYGRRT 450
    NFIGSYTLSC YDPDSGNFLP IGKVGTGITD ENLVELTGLF SDLIVVESGR 500
    DLEFKPEIVF EVAFEEIQKS TNYESGYALR FPRLVSIRDD KSPHEADTIS 550
    RVDEIYRSQR K 561
    Length:561
    Mass (Da):63,050
    Last modified:September 21, 2011 - v1
    Checksum:iD1AF3543A6495D18
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002101 Genomic DNA. Translation: AEH60729.1.
    RefSeqiYP_004615948.1. NC_015676.1.

    Genome annotation databases

    EnsemblBacteriaiAEH60729; AEH60729; Mzhil_0867.
    GeneIDi10822488.
    KEGGimzh:Mzhil_0867.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002101 Genomic DNA. Translation: AEH60729.1 .
    RefSeqi YP_004615948.1. NC_015676.1.

    3D structure databases

    ProteinModelPortali F7XL21.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH60729 ; AEH60729 ; Mzhil_0867 .
    GeneIDi 10822488.
    KEGGi mzh:Mzhil_0867.

    Phylogenomic databases

    KOi K10747.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MZHI679901:GHPZ-902-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 4017 / NBRC 107636 / OCM 62 / WeN5Imported.

    Entry informationi

    Entry nameiF7XL21_METZD
    AccessioniPrimary (citable) accession number: F7XL21
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3