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Protein

DNA ligase

Gene

lig

Organism
Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei245ATPUniRule annotation1
Active sitei247N6-AMP-lysine intermediateUniRule annotation1
Binding sitei252ATPUniRule annotation1
Binding sitei267ATPUniRule annotation1
Binding sitei297ATPUniRule annotation1
Binding sitei335ATPUniRule annotation1
Binding sitei412ATPUniRule annotation1
Binding sitei418ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mzhil_0684Imported
OrganismiMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)Imported
Taxonomic identifieri679901 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosalsum
Proteomesi
  • UP000006622 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi679901.Mzhil_0684

Structurei

3D structure databases

ProteinModelPortaliF7XK86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini323 – 458DNA_LIGASE_A3InterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F7XK86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLKELVEL YVEMENTSSH KKIVGLLTSF FRSLDPDDVR TAAYLVLGTV
60 70 80 90 100
GPEYEDTELG IREKLAIRSI ADAFGISRQK VEKTYSDTGD LGDAAFEFSS
110 120 130 140 150
NKNSDLTIRD VMDCLTQIKN TSGEGSQQKK IELLAEILAR ASAMEAKYIM
160 170 180 190 200
RITLGELRLG FGEQFVLSAL AMAFTGDDKN TVYLEEAYNV CTDIGQLAES
210 220 230 240 250
VSEYGLASIK RFSVKIGRPV RSMLAKRVDK FENLNDKFPE QMAAEEKYDG
260 270 280 290 300
ERIQVHIINE NIQIFSRRLD NITDQFPDVV DAVKKHIKAE KAVLDGEVIA
310 320 330 340 350
FRNENINSFQ ELMQRRRKYD VEEYVDKVPV VAYMFDIIYL NGKSYLKVPY
360 370 380 390 400
PHRRTALEEH LEENEKIRLV ERTVSADFNE IRSFFDRCID KGLEGIIIKS
410 420 430 440 450
VADNSFYQPG KRGWLWVKWK KEYAEDVRDT FDLIIVGFYS GKGKRQGLFG
460 470 480 490 500
SLLCAVLNKE KNQYETFTRV GTGFTDQDLE EISELLNKKK IKKKPPNLVV
510 520 530 540 550
EKEMVPDSYI DPSVVIEVLG SQVTESPHHT AGKNKSDKGY ALRFPRFLRM
560
RYDKGPLDVT TIEEVRNLL
Length:569
Mass (Da):64,974
Last modified:September 21, 2011 - v1
Checksum:i20C847FD2C44E2ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002101 Genomic DNA Translation: AEH60551.1

Genome annotation databases

EnsemblBacteriaiAEH60551; AEH60551; Mzhil_0684
KEGGimzh:Mzhil_0684

Similar proteinsi

Entry informationi

Entry nameiF7XK86_METZD
AccessioniPrimary (citable) accession number: F7XK86
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health