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F7XK86

- F7XK86_METZD

UniProt

F7XK86 - F7XK86_METZD

Protein

DNA ligase

Gene

lig

Organism
Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei245 – 2451ATPUniRule annotation
    Active sitei247 – 2471N6-AMP-lysine intermediateUniRule annotation
    Binding sitei252 – 2521ATPUniRule annotation
    Binding sitei267 – 2671ATPUniRule annotation
    Binding sitei297 – 2971ATPUniRule annotation
    Binding sitei335 – 3351ATPUniRule annotation
    Binding sitei412 – 4121ATPUniRule annotation
    Binding sitei418 – 4181ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMZHI679901:GHPZ-709-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Mzhil_0684Imported
    OrganismiMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)Imported
    Taxonomic identifieri679901 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosalsum
    ProteomesiUP000006622: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliF7XK86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiCTDIGEL.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7XK86-1 [UniParc]FASTAAdd to Basket

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    MASLKELVEL YVEMENTSSH KKIVGLLTSF FRSLDPDDVR TAAYLVLGTV    50
    GPEYEDTELG IREKLAIRSI ADAFGISRQK VEKTYSDTGD LGDAAFEFSS 100
    NKNSDLTIRD VMDCLTQIKN TSGEGSQQKK IELLAEILAR ASAMEAKYIM 150
    RITLGELRLG FGEQFVLSAL AMAFTGDDKN TVYLEEAYNV CTDIGQLAES 200
    VSEYGLASIK RFSVKIGRPV RSMLAKRVDK FENLNDKFPE QMAAEEKYDG 250
    ERIQVHIINE NIQIFSRRLD NITDQFPDVV DAVKKHIKAE KAVLDGEVIA 300
    FRNENINSFQ ELMQRRRKYD VEEYVDKVPV VAYMFDIIYL NGKSYLKVPY 350
    PHRRTALEEH LEENEKIRLV ERTVSADFNE IRSFFDRCID KGLEGIIIKS 400
    VADNSFYQPG KRGWLWVKWK KEYAEDVRDT FDLIIVGFYS GKGKRQGLFG 450
    SLLCAVLNKE KNQYETFTRV GTGFTDQDLE EISELLNKKK IKKKPPNLVV 500
    EKEMVPDSYI DPSVVIEVLG SQVTESPHHT AGKNKSDKGY ALRFPRFLRM 550
    RYDKGPLDVT TIEEVRNLL 569
    Length:569
    Mass (Da):64,974
    Last modified:September 21, 2011 - v1
    Checksum:i20C847FD2C44E2ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002101 Genomic DNA. Translation: AEH60551.1.
    RefSeqiWP_013897990.1. NC_015676.1.
    YP_004615770.1. NC_015676.1.

    Genome annotation databases

    EnsemblBacteriaiAEH60551; AEH60551; Mzhil_0684.
    GeneIDi10822295.
    KEGGimzh:Mzhil_0684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002101 Genomic DNA. Translation: AEH60551.1 .
    RefSeqi WP_013897990.1. NC_015676.1.
    YP_004615770.1. NC_015676.1.

    3D structure databases

    ProteinModelPortali F7XK86.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH60551 ; AEH60551 ; Mzhil_0684 .
    GeneIDi 10822295.
    KEGGi mzh:Mzhil_0684.

    Phylogenomic databases

    KOi K10747.
    OMAi CTDIGEL.

    Enzyme and pathway databases

    BioCyci MZHI679901:GHPZ-709-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 4017 / NBRC 107636 / OCM 62 / WeN5Imported.

    Entry informationi

    Entry nameiF7XK86_METZD
    AccessioniPrimary (citable) accession number: F7XK86
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3