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F7XK86

- F7XK86_METZD

UniProt

F7XK86 - F7XK86_METZD

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Protein

DNA ligase

Gene
lig, Mzhil_0684
Organism
Methanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei245 – 2451ATP By similarityUniRule annotation
Active sitei247 – 2471N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei252 – 2521ATP By similarityUniRule annotation
Binding sitei267 – 2671ATP By similarityUniRule annotation
Binding sitei297 – 2971ATP By similarityUniRule annotation
Binding sitei335 – 3351ATP By similarityUniRule annotation
Binding sitei412 – 4121ATP By similarityUniRule annotation
Binding sitei418 – 4181ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMZHI679901:GHPZ-709-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Mzhil_0684Imported
OrganismiMethanosalsum zhilinae (strain DSM 4017 / NBRC 107636 / OCM 62 / WeN5) (Methanohalophilus zhilinae)Imported
Taxonomic identifieri679901 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosalsum
ProteomesiUP000006622: Chromosome

Structurei

3D structure databases

ProteinModelPortaliF7XK86.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK10747.
OMAiCTDIGEL.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7XK86-1 [UniParc]FASTAAdd to Basket

« Hide

MASLKELVEL YVEMENTSSH KKIVGLLTSF FRSLDPDDVR TAAYLVLGTV    50
GPEYEDTELG IREKLAIRSI ADAFGISRQK VEKTYSDTGD LGDAAFEFSS 100
NKNSDLTIRD VMDCLTQIKN TSGEGSQQKK IELLAEILAR ASAMEAKYIM 150
RITLGELRLG FGEQFVLSAL AMAFTGDDKN TVYLEEAYNV CTDIGQLAES 200
VSEYGLASIK RFSVKIGRPV RSMLAKRVDK FENLNDKFPE QMAAEEKYDG 250
ERIQVHIINE NIQIFSRRLD NITDQFPDVV DAVKKHIKAE KAVLDGEVIA 300
FRNENINSFQ ELMQRRRKYD VEEYVDKVPV VAYMFDIIYL NGKSYLKVPY 350
PHRRTALEEH LEENEKIRLV ERTVSADFNE IRSFFDRCID KGLEGIIIKS 400
VADNSFYQPG KRGWLWVKWK KEYAEDVRDT FDLIIVGFYS GKGKRQGLFG 450
SLLCAVLNKE KNQYETFTRV GTGFTDQDLE EISELLNKKK IKKKPPNLVV 500
EKEMVPDSYI DPSVVIEVLG SQVTESPHHT AGKNKSDKGY ALRFPRFLRM 550
RYDKGPLDVT TIEEVRNLL 569
Length:569
Mass (Da):64,974
Last modified:September 21, 2011 - v1
Checksum:i20C847FD2C44E2ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002101 Genomic DNA. Translation: AEH60551.1.
RefSeqiWP_013897990.1. NC_015676.1.
YP_004615770.1. NC_015676.1.

Genome annotation databases

EnsemblBacteriaiAEH60551; AEH60551; Mzhil_0684.
GeneIDi10822295.
KEGGimzh:Mzhil_0684.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002101 Genomic DNA. Translation: AEH60551.1 .
RefSeqi WP_013897990.1. NC_015676.1.
YP_004615770.1. NC_015676.1.

3D structure databases

ProteinModelPortali F7XK86.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEH60551 ; AEH60551 ; Mzhil_0684 .
GeneIDi 10822295.
KEGGi mzh:Mzhil_0684.

Phylogenomic databases

KOi K10747.
OMAi CTDIGEL.

Enzyme and pathway databases

BioCyci MZHI679901:GHPZ-709-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 4017 / NBRC 107636 / OCM 62 / WeN5.

Entry informationi

Entry nameiF7XK86_METZD
AccessioniPrimary (citable) accession number: F7XK86
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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