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Protein

Xylose isomerase

Gene

xylA

Organism
Sinorhizobium meliloti (strain SM11)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei100 – 1001UniRule annotation
Active sitei103 – 1031UniRule annotation
Metal bindingi231 – 2311Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 1UniRule annotation
Metal bindingi267 – 2671Magnesium 2UniRule annotation
Metal bindingi270 – 2701Magnesium 2UniRule annotation
Metal bindingi295 – 2951Magnesium 1UniRule annotation
Metal bindingi306 – 3061Magnesium 2UniRule annotation
Metal bindingi308 – 3081Magnesium 2UniRule annotation
Metal bindingi338 – 3381Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotation

Keywords - Biological processi

Carbohydrate metabolism, Pentose shuntUniRule annotation, Xylose metabolismUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSMEL707241:GLKB-3065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotationImported
Ordered Locus Names:SM11_chr3066Imported
OrganismiSinorhizobium meliloti (strain SM11)Imported
Taxonomic identifieri707241 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
ProteomesiUP000009045: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliF7X9L1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

KOiK01805.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7X9L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTGFFGDIA KIKYEGPEST NPLAFRHYNP DDVVLGKRME DHLRFAVAYW
60 70 80 90 100
HTFVWPGGDP FGGQTFERPW FKDSMEAAKL KADVAFEFFQ LLGVPYYCFH
110 120 130 140 150
DADVRPEGRN FAENTSNLNA IVDYFAGKQE ETGVKLLWGT ANLFSNRRFM
160 170 180 190 200
AGAATNPDPD VFAFAAATVK TCIDATQRLD GENYVLWGGR EGYETLLNTD
210 220 230 240 250
LKRELDQLGR FLNLVVEYKH RIGFKGTILI EPKPQEPTKH QYDYDVATVY
260 270 280 290 300
GFLKRYGLEN EVKVNIEQGH AILAGHSFEH ELALANALGI FGSIDMNRND
310 320 330 340 350
YQSGWDTDQF PNNVPEMALA YYHVLAGGGF KTGGTNFDAK LRRQSIDPED
360 370 380 390 400
LLIGHIGGMD CCARGLKAAA KMIEDKALSA PLEARYAGWN VPEAKKMLDG
410 420 430
GFSLEEIEAW VLKSDVNPQP KSGRQELLEN VVNRYV
Length:436
Mass (Da):48,928
Last modified:September 21, 2011 - v1
Checksum:i91CEF4BD1BC686CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001830 Genomic DNA. Translation: AEH80310.1.
RefSeqiYP_005721571.1. NC_017325.1.

Genome annotation databases

EnsemblBacteriaiAEH80310; AEH80310; SM11_chr3066.
GeneIDi12309694.
KEGGismx:SM11_chr3066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001830 Genomic DNA. Translation: AEH80310.1.
RefSeqiYP_005721571.1. NC_017325.1.

3D structure databases

ProteinModelPortaliF7X9L1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEH80310; AEH80310; SM11_chr3066.
GeneIDi12309694.
KEGGismx:SM11_chr3066.

Phylogenomic databases

KOiK01805.

Enzyme and pathway databases

BioCyciSMEL707241:GLKB-3065-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the dominant Sinorhizobium meliloti field isolate SM11 extends the S. meliloti pan-genome."
    Schneiker-Bekel S., Wibberg D., Bekel T., Blom J., Linke B., Neuweger H., Stiens M., Vorholter F.J., Weidner S., Goesmann A., Puhler A., Schluter A.
    J. Biotechnol. 155:20-33(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SM11Imported.

Entry informationi

Entry nameiF7X9L1_SINMM
AccessioniPrimary (citable) accession number: F7X9L1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 4, 2015
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.