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F7X584 (F7X584_SINMM) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP-Rule MF_00116
Short name=dUTPase HAMAP-Rule MF_00116
EC=3.6.1.23 HAMAP-Rule MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP-Rule MF_00116
Gene names
Name:dnaS EMBL AEH81048.1
Synonyms:dut HAMAP-Rule MF_00116
Ordered Locus Names:SM11_chr3822 EMBL AEH81048.1
OrganismSinorhizobium meliloti (strain SM11) [Complete proteome] [HAMAP] EMBL AEH81048.1
Taxonomic identifier707241 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Sinorhizobium/Ensifer group › Sinorhizobium ›

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP-Rule MF_00116

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP-Rule MF_00116

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00116

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP-Rule MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP-Rule MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region81 – 833Substrate binding By similarity HAMAP-Rule MF_00116
Region98 – 1003Substrate binding By similarity HAMAP-Rule MF_00116

Sites

Binding site941Substrate By similarity HAMAP-Rule MF_00116
Binding site1081Substrate; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00116

Sequences

Sequence LengthMass (Da)Tools
F7X584 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 59A932AC3E454AB1

FASTA16216,956
        10         20         30         40         50         60 
MTMHTPENRP ALTPGLTLVR LPHGEGLDLP AYETAGAAGM DLRAALPADE PMTIRPGERA 

        70         80         90        100        110        120 
LVPTGFIFEI PAGHEGQIRP RSGLAFKHGI TCLNTPGTVD SDYRGEVKVL LVNLGAEDFA 

       130        140        150        160 
VERGMRIAQM VIAPVTRLAI REAGGATTTA RGAGGFGSTG TK

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References

[1]"The complete genome sequence of the dominant Sinorhizobium meliloti field isolate SM11 extends the S. meliloti pan-genome."
Schneiker-Bekel S., Wibberg D., Bekel T., Blom J., Linke B., Neuweger H., Stiens M., Vorholter F.J., Weidner S., Goesmann A., Puhler A., Schluter A.
J. Biotechnol. 155:20-33(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SM11 EMBL AEH81048.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001830 Genomic DNA. Translation: AEH81048.1.
RefSeqYP_005722309.1. NC_017325.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEH81048; AEH81048; SM11_chr3822.
GeneID12309256.
KEGGsmx:SM11_chr3822.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01520.

Enzyme and pathway databases

UniPathwayUPA00610; UER00666.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameF7X584_SINMM
AccessionPrimary (citable) accession number: F7X584
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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