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F7X514

- F7X514_SINMM

UniProt

F7X514 - F7X514_SINMM

Protein

Alanine racemase

Gene

alr

Organism
Sinorhizobium meliloti (strain SM11)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei54 – 541Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Active sitei273 – 2731Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei332 – 3321Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSMEL707241:GLKB-2536-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:SM11_chr2537Imported
    OrganismiSinorhizobium meliloti (strain SM11)Imported
    Taxonomic identifieri707241 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
    ProteomesiUP000009045: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF7X514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7X514-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYCCRYRPRR VFGMQSPEFL SASSRLTVDL TALADNWRAM NERSGKARAA    50
    AVLKADAYGL GVVHAAPALY AAGARDFFVA SVEEGADLRP LVPDGRIYIL 100
    AGMWPGNEEL FFENDLVPII NSEEQLAVFM AALSERGDHP CVLHVDTGMN 150
    RLGLSPEEAL ALAHDPARPA SFSPVLVMSH LACADDPGHP MNRYQLQRFR 200
    EVTAAFEGVP ASLANSGGVF LGADYHFDLT RPGIAVYGGE AVNGAVNPMK 250
    AVVTAEARIV QVRTVPSGGT ASYGASVRFG RDSRIATVAI GYADGYHRSV 300
    SGGGVTLRQA MPSGAFGFLH GMKVPHVGRV TMDLSLFDVT DLPEAAVRAG 350
    DYIEVFGRNV VIDDVARAGG TIGYELLTSL GRRYHRTYVG GA 392
    Length:392
    Mass (Da):41,923
    Last modified:September 21, 2011 - v1
    Checksum:iD8D9511570C83B50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001830 Genomic DNA. Translation: AEH79790.1.
    RefSeqiYP_005721051.1. NC_017325.1.

    Genome annotation databases

    EnsemblBacteriaiAEH79790; AEH79790; SM11_chr2537.
    GeneIDi12310982.
    KEGGismx:SM11_chr2537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001830 Genomic DNA. Translation: AEH79790.1 .
    RefSeqi YP_005721051.1. NC_017325.1.

    3D structure databases

    ProteinModelPortali F7X514.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEH79790 ; AEH79790 ; SM11_chr2537 .
    GeneIDi 12310982.
    KEGGi smx:SM11_chr2537.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci SMEL707241:GLKB-2536-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the dominant Sinorhizobium meliloti field isolate SM11 extends the S. meliloti pan-genome."
      Schneiker-Bekel S., Wibberg D., Bekel T., Blom J., Linke B., Neuweger H., Stiens M., Vorholter F.J., Weidner S., Goesmann A., Puhler A., Schluter A.
      J. Biotechnol. 155:20-33(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SM11Imported.

    Entry informationi

    Entry nameiF7X514_SINMM
    AccessioniPrimary (citable) accession number: F7X514
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3