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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Sinorhizobium meliloti (strain SM11)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotationImported
Ordered Locus Names:SM11_chr1138Imported
OrganismiSinorhizobium meliloti (strain SM11)Imported
Taxonomic identifieri707241 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeSinorhizobium/Ensifer groupSinorhizobium
Proteomesi
  • UP000009045 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei27 – 49HelicalUniRule annotationAdd BLAST23
Transmembranei69 – 90HelicalUniRule annotationAdd BLAST22
Transmembranei96 – 114HelicalUniRule annotationAdd BLAST19
Transmembranei134 – 154HelicalUniRule annotationAdd BLAST21
Transmembranei174 – 193HelicalUniRule annotationAdd BLAST20
Transmembranei205 – 225HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 262HelicalUniRule annotationAdd BLAST18
Transmembranei269 – 288HelicalUniRule annotationAdd BLAST20
Transmembranei294 – 317HelicalUniRule annotationAdd BLAST24
Transmembranei344 – 363HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, Membrane

Structurei

3D structure databases

ProteinModelPortaliF7X422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

F7X422-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIWLVELAD HFQFFNLFRY ITFRTGAALF TSALIVFLFG PAMIASLRIR
60 70 80 90 100
QGKGQPIRAD GPQTHFKKAG TPTMGGLMIL TGIVVSSLLW ADLSSIYVVS
110 120 130 140 150
TLLVTLGFGA IGFYDDYLKV TKQSEKGFSG KARLGIEFVI AAVAVFFMMQ
160 170 180 190 200
AALSAGAAGS TFGSSVTFPF FKDLMLNLGY FFVLFGGFVI VGAGNSVNLT
210 220 230 240 250
DGLDGLAIVP VMIASAAFGL IAYLAGNAVF ANYLQIHFVP GTGELAVILG
260 270 280 290 300
AVIGAGLGFL WFNAPPAAIF MGDTGSLALG GLIGTVAVAT KHEIVMIIIG
310 320 330 340 350
GLFVIETLSV IIQVFWFKRT GHRVFLMAPI HHHFEKKGWT ESQVVIRFWI
360
IAVILAMVGL STLKLR
Length:366
Mass (Da):39,266
Last modified:September 21, 2011 - v1
Checksum:iF42FB33AAB5491CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001830 Genomic DNA. Translation: AEH78415.1.
RefSeqiWP_003529135.1. NC_017325.1.

Genome annotation databases

EnsemblBacteriaiAEH78415; AEH78415; SM11_chr1138.
KEGGismx:SM11_chr1138.
PATRICifig|707241.3.peg.1198.

Similar proteinsi

Entry informationi

Entry nameiF7X422_SINMM
AccessioniPrimary (citable) accession number: F7X422
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 27, 2017
This is version 36 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported