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F7WS03

- F7WS03_MYCTD

UniProt

F7WS03 - F7WS03_MYCTD

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Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium tuberculosis (strain CCDC5180)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Active sitei295 – 2951Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei343 – 3431Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciMTUB443150:GLGS-3163-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CCDC5180_3122Imported
ORF Names:CFBR_3632Imported
OrganismiMycobacterium tuberculosis (strain CCDC5180)Imported
Taxonomic identifieri443150 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000302: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF7WS03.
SMRiF7WS03. Positions 35-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiPSECAGV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7WS03-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRFWENVGK PNDTTDGRGT TSLAMTPISQ TPGLLAEAMV DLGAIEHNVR
60 70 80 90 100
VLREHAGHAQ LMAVVKADGY GHGATRVAQT ALGAGAAELG VATVDEALAL
110 120 130 140 150
RADGITAPVL AWLHPPGIDF GPALLADVQV AVSSLRQLDE LLHAVRRTGR
160 170 180 190 200
TATVTVKVDT GLNRNGVGPA QFPAMLTALR QAMAEDAVRL RGLMSHMVYA
210 220 230 240 250
DKPDDSINDV QAQRFTAFLA QAREQGVRFE VAHLSNSSAT MARPDLTFDL
260 270 280 290 300
VRPGIAVYGL SPVPALGDMG LVPAMTVKCA VALVKSIRAG EGVSYGHTWI
310 320 330 340 350
APRDTNLALL PIGYADGVFR SLGGRLEVLI NGRRCPGVGR ICMDQFMVDL
360 370 380 390 400
GPGPLDVAEG DEAILFGPGI RGEPTAQDWA DLVGTIHYEV VTSPRGRITR

TYREAENR
Length:408
Mass (Da):43,388
Last modified:September 21, 2011 - v1
Checksum:i44FECA297BA7C8E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001642 Genomic DNA. Translation: AEJ51959.1.
CP002885 Genomic DNA. Translation: AHJ56717.1.
RefSeqiYP_005910954.1. NC_017522.1.

Genome annotation databases

EnsemblBacteriaiAEJ51959; AEJ51959; CCDC5180_3122.
GeneIDi12500999.
KEGGimtl:CCDC5180_3122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001642 Genomic DNA. Translation: AEJ51959.1 .
CP002885 Genomic DNA. Translation: AHJ56717.1 .
RefSeqi YP_005910954.1. NC_017522.1.

3D structure databases

ProteinModelPortali F7WS03.
SMRi F7WS03. Positions 35-405.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEJ51959 ; AEJ51959 ; CCDC5180_3122 .
GeneIDi 12500999.
KEGGi mtl:CCDC5180_3122.

Phylogenomic databases

KOi K01775.
OMAi PSECAGV.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MTUB443150:GLGS-3163-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genome sequences of Mycobacterium tuberculosis strains CCDC5079 and CCDC5080, which belong to the Beijing family."
    Zhang Y., Chen C., Liu J., Deng H., Pan A., Zhang L., Zhao X., Huang M., Lu B., Dong H., Du P., Chen W., Wan K.
    J. Bacteriol. 193:5591-5592(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCDC5180Imported.
  2. "Beijing/W Lineage of Mycobacterium tuberculosis Develop Totally Drug Resistant Phenotype by Reductive Evolution."
    Wan K., Liu H., Tang B., Jiang Y., Zheng H., Zhang Y., Lv B., Liu Z., Zhao X., Dong H., Zhao G.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCDC5180Imported.

Entry informationi

Entry nameiF7WS03_MYCTD
AccessioniPrimary (citable) accession number: F7WS03
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3