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F7WS03

- F7WS03_MYCTD

UniProt

F7WS03 - F7WS03_MYCTD

Protein

Alanine racemase

Gene

alr

Organism
Mycobacterium tuberculosis (strain CCDC5180)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Active sitei295 – 2951Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei343 – 3431Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMTUB443150:GLGS-3163-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    Ordered Locus Names:CCDC5180_3122Imported
    ORF Names:CFBR_3632Imported
    OrganismiMycobacterium tuberculosis (strain CCDC5180)Imported
    Taxonomic identifieri443150 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000000302: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei66 – 661N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF7WS03.
    SMRiF7WS03. Positions 35-405.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.
    OMAiPSECAGV.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7WS03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRFWENVGK PNDTTDGRGT TSLAMTPISQ TPGLLAEAMV DLGAIEHNVR    50
    VLREHAGHAQ LMAVVKADGY GHGATRVAQT ALGAGAAELG VATVDEALAL 100
    RADGITAPVL AWLHPPGIDF GPALLADVQV AVSSLRQLDE LLHAVRRTGR 150
    TATVTVKVDT GLNRNGVGPA QFPAMLTALR QAMAEDAVRL RGLMSHMVYA 200
    DKPDDSINDV QAQRFTAFLA QAREQGVRFE VAHLSNSSAT MARPDLTFDL 250
    VRPGIAVYGL SPVPALGDMG LVPAMTVKCA VALVKSIRAG EGVSYGHTWI 300
    APRDTNLALL PIGYADGVFR SLGGRLEVLI NGRRCPGVGR ICMDQFMVDL 350
    GPGPLDVAEG DEAILFGPGI RGEPTAQDWA DLVGTIHYEV VTSPRGRITR 400
    TYREAENR 408
    Length:408
    Mass (Da):43,388
    Last modified:September 21, 2011 - v1
    Checksum:i44FECA297BA7C8E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001642 Genomic DNA. Translation: AEJ51959.1.
    CP002885 Genomic DNA. Translation: AHJ56717.1.
    RefSeqiYP_005910954.1. NC_017522.1.

    Genome annotation databases

    EnsemblBacteriaiAEJ51959; AEJ51959; CCDC5180_3122.
    GeneIDi12500999.
    KEGGimtl:CCDC5180_3122.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001642 Genomic DNA. Translation: AEJ51959.1 .
    CP002885 Genomic DNA. Translation: AHJ56717.1 .
    RefSeqi YP_005910954.1. NC_017522.1.

    3D structure databases

    ProteinModelPortali F7WS03.
    SMRi F7WS03. Positions 35-405.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEJ51959 ; AEJ51959 ; CCDC5180_3122 .
    GeneIDi 12500999.
    KEGGi mtl:CCDC5180_3122.

    Phylogenomic databases

    KOi K01775.
    OMAi PSECAGV.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MTUB443150:GLGS-3163-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequences of Mycobacterium tuberculosis strains CCDC5079 and CCDC5080, which belong to the Beijing family."
      Zhang Y., Chen C., Liu J., Deng H., Pan A., Zhang L., Zhao X., Huang M., Lu B., Dong H., Du P., Chen W., Wan K.
      J. Bacteriol. 193:5591-5592(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CCDC5180Imported.
    2. "Beijing/W Lineage of Mycobacterium tuberculosis Develop Totally Drug Resistant Phenotype by Reductive Evolution."
      Wan K., Liu H., Tang B., Jiang Y., Zheng H., Zhang Y., Lv B., Liu Z., Zhao X., Dong H., Zhao G.
      Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CCDC5180Imported.

    Entry informationi

    Entry nameiF7WS03_MYCTD
    AccessioniPrimary (citable) accession number: F7WS03
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3