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F7WS03

- F7WS03_MYCTD

UniProt

F7WS03 - F7WS03_MYCTD

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Protein
Alanine racemase
Gene
alr, CCDC5180_3122, CFBR_3632
Organism
Mycobacterium tuberculosis (strain CCDC5180)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei164 – 1641Substrate By similarityUniRule annotation
Active sitei295 – 2951Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei343 – 3431Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMTUB443150:GLGS-3163-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:CCDC5180_3122Imported
ORF Names:CFBR_3632Imported
OrganismiMycobacterium tuberculosis (strain CCDC5180)Imported
Taxonomic identifieri443150 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000302: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF7WS03.
SMRiF7WS03. Positions 35-405.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.
OMAiPSECAGV.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7WS03-1 [UniParc]FASTAAdd to Basket

« Hide

MKRFWENVGK PNDTTDGRGT TSLAMTPISQ TPGLLAEAMV DLGAIEHNVR    50
VLREHAGHAQ LMAVVKADGY GHGATRVAQT ALGAGAAELG VATVDEALAL 100
RADGITAPVL AWLHPPGIDF GPALLADVQV AVSSLRQLDE LLHAVRRTGR 150
TATVTVKVDT GLNRNGVGPA QFPAMLTALR QAMAEDAVRL RGLMSHMVYA 200
DKPDDSINDV QAQRFTAFLA QAREQGVRFE VAHLSNSSAT MARPDLTFDL 250
VRPGIAVYGL SPVPALGDMG LVPAMTVKCA VALVKSIRAG EGVSYGHTWI 300
APRDTNLALL PIGYADGVFR SLGGRLEVLI NGRRCPGVGR ICMDQFMVDL 350
GPGPLDVAEG DEAILFGPGI RGEPTAQDWA DLVGTIHYEV VTSPRGRITR 400
TYREAENR 408
Length:408
Mass (Da):43,388
Last modified:September 21, 2011 - v1
Checksum:i44FECA297BA7C8E2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001642 Genomic DNA. Translation: AEJ51959.1.
CP002885 Genomic DNA. Translation: AHJ56717.1.
RefSeqiYP_005910954.1. NC_017522.1.

Genome annotation databases

EnsemblBacteriaiAEJ51959; AEJ51959; CCDC5180_3122.
GeneIDi12500999.
KEGGimtl:CCDC5180_3122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001642 Genomic DNA. Translation: AEJ51959.1 .
CP002885 Genomic DNA. Translation: AHJ56717.1 .
RefSeqi YP_005910954.1. NC_017522.1.

3D structure databases

ProteinModelPortali F7WS03.
SMRi F7WS03. Positions 35-405.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEJ51959 ; AEJ51959 ; CCDC5180_3122 .
GeneIDi 12500999.
KEGGi mtl:CCDC5180_3122.

Phylogenomic databases

KOi K01775.
OMAi PSECAGV.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MTUB443150:GLGS-3163-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete Genome Sequences of Mycobacterium tuberculosis Strains CCDC5079 and CCDC5080, Which Belong to the Beijing Family."
    Zhang Y., Chen C., Liu J., Deng H., Pan A., Zhang L., Zhao X., Huang M., Lu B., Dong H., Du P., Chen W., Wan K.
    J. Bacteriol. 193:5591-5592(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CCDC5180Imported.
  2. "Beijing/W Lineage of Mycobacterium tuberculosis Develop Totally Drug Resistant Phenotype by Reductive Evolution."
    Wan K., Liu H., Tang B., Jiang Y., Zheng H., Zhang Y., Lv B., Liu Z., Zhao X., Dong H., Zhao G.
    Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCDC5180Imported.

Entry informationi

Entry nameiF7WS03_MYCTD
AccessioniPrimary (citable) accession number: F7WS03
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi