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Protein

Kynureninase

Gene

BNA5

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (BNA5), Kynureninase (BNA5)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Kynurenine 3-monooxygenase (BNA4)
  2. Kynureninase (BNA5), Kynureninase (BNA5)
  3. 3-hydroxyanthranilate 3,4-dioxygenase (BNA1)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei152Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei153Pyridoxal phosphateUniRule annotation1
Binding sitei264Pyridoxal phosphateUniRule annotation1
Binding sitei267Pyridoxal phosphateUniRule annotation1
Binding sitei289Pyridoxal phosphateUniRule annotation1
Binding sitei327Pyridoxal phosphateUniRule annotation1
Binding sitei355Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
Biosynthesis of nicotinic acid protein 5UniRule annotation
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:BNA5UniRule annotation
ORF Names:SMAC_08947Imported
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)Imported
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:SMAC_08947

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei290N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi771870.XP_003353189.1

Structurei

3D structure databases

ProteinModelPortaliF7WB68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 397Aminotran_5InterPro annotationAdd BLAST279

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 183Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3846 Eukaryota
COG3844 LUCA
KOiK01556
OrthoDBiEOG092C20ON

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 2 hits
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

F7WB68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFTSKVEV LRDGQKPEFP SNANTLEYAQ SLDAQDELRH FRDEFIIPTR
60 70 80 90 100
GSLKKRALDG TIPGVPTPGT TEADTPCIYF VGNSLGAQPK AVRTYLEAQL
110 120 130 140 150
ETWASIGVNG HFSSMSNSPL APWQDMAADC AAKSAAIVGA ADPSEVVMMN
160 170 180 190 200
TLTVNLHFMM ASFYRPTEKR HKIILEWRPF PSDWYAFQSQ IEWHGLDPEK
210 220 230 240 250
SMVEIQPDEN LYLSTEKILK TIDEHAEDAA LLLLPGIQYY TGQLFDIPRI
260 270 280 290 300
TKYAQERGLV VGWDLAHCAG NVELQLHDWN VDFAVWCTYK YLNGGPGSMA
310 320 330 340 350
GAFVHERHGK VDMSSGKPVF KPRLSGWYGA DKSVRFNMDK EFQPTPGAQG
360 370 380 390 400
FQISNPSAID LTSLAAALSV FNKTSMKDLR SKALVLTAYT EHLLDEIVRR
410 420 430 440 450
QPEGEEPAFK IITPRDPLQR GTQLSLLLRD GLMDKVAAAL EENGVVCDKR
460 470 480
KPNVIRVAPV PMYCRFEDVW KFMEIFEGAI RG
Length:482
Mass (Da):53,898
Last modified:September 21, 2011 - v1
Checksum:iEED943F2B1D0041C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000070 Genomic DNA Translation: CCC14360.1
RefSeqiXP_003353189.1, XM_003353141.1

Genome annotation databases

EnsemblFungiiCCC14360; CCC14360; SMAC_08947
GeneIDi10810850
KEGGismp:SMAC_08947

Similar proteinsi

Entry informationi

Entry nameiF7WB68_SORMK
AccessioniPrimary (citable) accession number: F7WB68
Entry historyiIntegrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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