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Protein

Malate dehydrogenase

Gene

SMAC_07106

Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
ORF Names:SMAC_07106Imported
OrganismiSordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)Imported
Taxonomic identifieri771870 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeSordaria
ProteomesiUP000001881 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:SMAC_07106.

Interactioni

Protein-protein interaction databases

STRINGi771870.XP_003345822.1.

Structurei

3D structure databases

ProteinModelPortaliF7W7J8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

InParanoidiF7W7J8.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7W7J8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKAVVAGAA GGIGQPLSLL LKLSPLVDEL SLYDVVNTPG VAADLSHISS
60 70 80 90 100
TAKTTGYLPP NDGAKAAFKD ADIIVIPAGI PRKPGMTRDD LFNINAGIVK
110 120 130 140 150
GLIEVAAEVA PNAFILVISN PVNSTVPISA EVLKAKGVFN AQRLFGVTTL
160 170 180 190 200
DIVRAETFVA EIAGKSNPQE LVVPVIGGHS GETIVPLFSK VTPSVTIPDD
210 220 230 240 250
KYDALVNRVQ FGGDEVVKAK EGLGSATLSM AYAGYRFAEK LLKASKGAKG
260 270 280 290 300
LVEPSYVYLP GIPGGKEIAE KTGVDFFSVP IELGPNGAEK AIDILGDITE
310 320 330
KEKTLLEAAV KGLKGNIQKG VDFAHNPPQK
Length:330
Mass (Da):34,360
Last modified:September 21, 2011 - v1
Checksum:i2BA774C53398EF20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000039 Genomic DNA. Translation: CCC13482.1.
RefSeqiXP_003345822.1. XM_003345774.1.

Genome annotation databases

GeneIDi10803190.
KEGGismp:SMAC_07106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABT02000039 Genomic DNA. Translation: CCC13482.1.
RefSeqiXP_003345822.1. XM_003345774.1.

3D structure databases

ProteinModelPortaliF7W7J8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi771870.XP_003345822.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10803190.
KEGGismp:SMAC_07106.

Organism-specific databases

EuPathDBiFungiDB:SMAC_07106.

Phylogenomic databases

InParanoidiF7W7J8.
KOiK00026.
OrthoDBiEOG7GJ6Q7.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis."
    Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K., Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S., Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.
    PLoS Genet. 6:E1000891-E1000891(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC MYA-333 / DSM 997 / K(L3346) / K-hellImported.
    Tissue: MyceliumImported.

Entry informationi

Entry nameiF7W7J8_SORMK
AccessioniPrimary (citable) accession number: F7W7J8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.