Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

F7VJQ1

- APRIO_HUMAN

UniProt

F7VJQ1 - APRIO_HUMAN

Protein

Alternative prion protein

Gene

PRNP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alternative prion protein
    Alternative name(s):
    AltPrP
    Gene namesi
    Name:PRNP
    Synonyms:ALTPRP, PRIP, PRP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:9449. PRNP.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial outer membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7373Alternative prion proteinPRO_0000420424Add
    BLAST

    Expressioni

    Tissue specificityi

    Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level).1 Publication

    Inductioni

    Up-regulated by endoplasmic reticulum stress and proteasomal inhibition.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliF7VJQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 6440Trp-richAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK05634.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative initiation. Align

    Isoform 3 (identifier: F7VJQ1-1) [UniParc]FASTAAdd to Basket

    Also known as: AltPrP

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEHWGQPIPG AGQPWRQPLP TSGRWWLGAA SWWWLGAASW WWLGAAPWWW   50
    LGTASWWWLG SRRWHPQSVE QAE 73
    Length:73
    Mass (Da):8,691
    Last modified:September 21, 2011 - v1
    Checksum:i4360C28341A4CA52
    GO
    Isoform 1 (identifier: P04156-1) [UniParc]FASTAAdd to Basket

    Also known as: PrP

    The sequence of this isoform can be found in the external entry P04156.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:253
    Mass (Da):27,661
    GO
    Isoform 2 (identifier: P04156-2) [UniParc]FASTAAdd to Basket

    Also known as: PrP(M8)

    The sequence of this isoform can be found in the external entry P04156.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:246
    Mass (Da):26,885
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133396 Genomic DNA. No translation available.
    BK007887 Genomic DNA. Translation: DAA34790.1.
    RefSeqiNP_001258490.1. NM_001271561.1.
    UniGeneiHs.472010.
    Hs.610285.
    Hs.721670.

    Genome annotation databases

    GeneIDi5621.
    KEGGihsa:5621.
    UCSCiuc002wkw.4. human.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133396 Genomic DNA. No translation available.
    BK007887 Genomic DNA. Translation: DAA34790.1 .
    RefSeqi NP_001258490.1. NM_001271561.1.
    UniGenei Hs.472010.
    Hs.610285.
    Hs.721670.

    3D structure databases

    ProteinModelPortali F7VJQ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5621.
    KEGGi hsa:5621.
    UCSCi uc002wkw.4. human.

    Organism-specific databases

    CTDi 5621.
    GeneReviewsi PRNP.
    HGNCi HGNC:9449. PRNP.
    neXtProti NX_F7VJQ1.
    GenAtlasi Search...

    Phylogenomic databases

    KOi K05634.

    Miscellaneous databases

    GeneWikii PRNP.
    GenomeRNAii 5621.
    NextBioi 35510517.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein."
      Vanderperre B., Staskevicius A.B., Tremblay G., McCoy M., O'Neill M.A., Cashman N.R., Roucou X.
      FASEB J. 25:2373-2386(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAPRIO_HUMAN
    AccessioniPrimary (citable) accession number: F7VJQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2012
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.1 Publication
    The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM

    External Data

    Dasty 3