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Protein

Alternative prion protein

Gene

PRNP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Alternative prion protein
Alternative name(s):
AltPrP
Gene namesi
Name:PRNP
Synonyms:ALTPRP, PRIP, PRP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:9449. PRNP.

Subcellular locationi

Mitochondrion outer membrane 1 Publication; Single-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7373Alternative prion proteinPRO_0000420424Add
BLAST

Expressioni

Tissue specificityi

Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level).1 Publication

Inductioni

Up-regulated by endoplasmic reticulum stress and proteasomal inhibition.1 Publication

Structurei

3D structure databases

ProteinModelPortaliF7VJQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 6440Trp-richAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK05634.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 3 (identifier: F7VJQ1-1) [UniParc]FASTAAdd to basket

Also known as: AltPrP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEHWGQPIPG AGQPWRQPLP TSGRWWLGAA SWWWLGAASW WWLGAAPWWW
60 70
LGTASWWWLG SRRWHPQSVE QAE
Length:73
Mass (Da):8,691
Last modified:September 21, 2011 - v1
Checksum:i4360C28341A4CA52
GO
Isoform 1 (identifier: P04156-1) [UniParc]FASTAAdd to basket

Also known as: PrP

The sequence of this isoform can be found in the external entry P04156.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:253
Mass (Da):27,661
GO
Isoform 2 (identifier: P04156-2) [UniParc]FASTAAdd to basket

Also known as: PrP(M8)

The sequence of this isoform can be found in the external entry P04156.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:246
Mass (Da):26,885
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133396 Genomic DNA. No translation available.
BK007887 Genomic DNA. Translation: DAA34790.1.
RefSeqiNP_001258490.1. NM_001271561.1. [F7VJQ1-1]
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

Genome annotation databases

GeneIDi5621.
KEGGihsa:5621.
UCSCiuc002wkw.4. human. [F7VJQ1-1]

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133396 Genomic DNA. No translation available.
BK007887 Genomic DNA. Translation: DAA34790.1.
RefSeqiNP_001258490.1. NM_001271561.1. [F7VJQ1-1]
UniGeneiHs.472010.
Hs.610285.
Hs.721670.

3D structure databases

ProteinModelPortaliF7VJQ1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5621.
KEGGihsa:5621.
UCSCiuc002wkw.4. human. [F7VJQ1-1]

Organism-specific databases

CTDi5621.
GeneReviewsiPRNP.
HGNCiHGNC:9449. PRNP.
neXtProtiNX_F7VJQ1.
GenAtlasiSearch...

Phylogenomic databases

KOiK05634.

Miscellaneous databases

ChiTaRSiPRNP. human.
GeneWikiiPRNP.
GenomeRNAii5621.
NextBioi35510517.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein."
    Vanderperre B., Staskevicius A.B., Tremblay G., McCoy M., O'Neill M.A., Cashman N.R., Roucou X.
    FASEB J. 25:2373-2386(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAPRIO_HUMAN
AccessioniPrimary (citable) accession number: F7VJQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2012
Last sequence update: September 21, 2011
Last modified: January 7, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the major prion protein/PRNP from an overlapping reading frame.1 Publication
The alternative prion protein/AltPrP and PRNP (AC P04156) have no apparent direct functional relation since a mutation that removes the start codon of the AltPrP has no apparent effect on the biology of PRNP. In mouse and hamster, the alternative initiation AUG codon is absent and is replaced by a GUG codon (PubMed:21478263).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.