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F7V6E7

- F7V6E7_CLOSS

UniProt

F7V6E7 - F7V6E7_CLOSS

Protein

Alanine racemase

Gene

CXIVA_23590

Organism
Clostridium sp. (strain SY8519)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (21 Sep 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Active sitei269 – 2691Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciCSP1042156:GHDR-2411-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:CXIVA_23590Imported
    OrganismiClostridium sp. (strain SY8519)Imported
    Taxonomic identifieri1042156 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000008937: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliF7V6E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    F7V6E7-1 [UniParc]FASTAAdd to Basket

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    MKAYSRVHAD IDLDAFSYNL QQIKNCRADS STKIMAVIKT DGYGHGALAL    50
    SEVLEQEEDI WGYAVASVDE GKILRRAGRR KPILILGYSF PDQYEEMIDL 100
    DIRTAVFSFE TARQISKAAR KLGKTAKIHI KLDTGMSRIG FSITEDSADD 150
    IVSISQLPNL EIEGIFTHFA RADEKDKRFT ECQAEAFDRM IDLLMVRGLR 200
    IPIHHISNSA GIIDLPQYNK DMVRAGIILY GLWPSDEVDR SRIRLKPLMS 250
    IHSQVVLVKK LGPGRSISYG GTYKTSTDEV IATVPVGYGD GYPRSLSNKG 300
    YVLIRGCRAP IRGRVCMDQF MVDVTHIPDV QQGEPVILLG RDGEQEITME 350
    ELGELSGRFN YELACDLSKR IPRNYLKNGE IVSQYDFFAE 390
    Length:390
    Mass (Da):43,825
    Last modified:September 21, 2011 - v1
    Checksum:i164EAB872F75BCDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012212 Genomic DNA. Translation: BAK48326.1.
    RefSeqiWP_013978283.1. NC_015737.1.
    YP_004709428.1. NC_015737.1.

    Genome annotation databases

    EnsemblBacteriaiBAK48326; BAK48326; CXIVA_23590.
    GeneIDi10925732.
    KEGGicls:CXIVA_23590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012212 Genomic DNA. Translation: BAK48326.1 .
    RefSeqi WP_013978283.1. NC_015737.1.
    YP_004709428.1. NC_015737.1.

    3D structure databases

    ProteinModelPortali F7V6E7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAK48326 ; BAK48326 ; CXIVA_23590 .
    GeneIDi 10925732.
    KEGGi cls:CXIVA_23590.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci CSP1042156:GHDR-2411-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of the O-desmethylangolensin-producing bacterium Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human intestine."
      Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.
      J. Bacteriol. 193:5568-5569(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SY8519Imported.

    Entry informationi

    Entry nameiF7V6E7_CLOSS
    AccessioniPrimary (citable) accession number: F7V6E7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 21, 2011
    Last sequence update: September 21, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3