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F7V6E7

- F7V6E7_CLOSS

UniProt

F7V6E7 - F7V6E7_CLOSS

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Protein
Alanine racemase
Gene
CXIVA_23590
Organism
Clostridium sp. (strain SY8519)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei138 – 1381Substrate By similarityUniRule annotation
Active sitei269 – 2691Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotations

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCSP1042156:GHDR-2411-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CXIVA_23590Imported
OrganismiClostridium sp. (strain SY8519)
Taxonomic identifieri1042156 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008937: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF7V6E7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

F7V6E7-1 [UniParc]FASTAAdd to Basket

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MKAYSRVHAD IDLDAFSYNL QQIKNCRADS STKIMAVIKT DGYGHGALAL    50
SEVLEQEEDI WGYAVASVDE GKILRRAGRR KPILILGYSF PDQYEEMIDL 100
DIRTAVFSFE TARQISKAAR KLGKTAKIHI KLDTGMSRIG FSITEDSADD 150
IVSISQLPNL EIEGIFTHFA RADEKDKRFT ECQAEAFDRM IDLLMVRGLR 200
IPIHHISNSA GIIDLPQYNK DMVRAGIILY GLWPSDEVDR SRIRLKPLMS 250
IHSQVVLVKK LGPGRSISYG GTYKTSTDEV IATVPVGYGD GYPRSLSNKG 300
YVLIRGCRAP IRGRVCMDQF MVDVTHIPDV QQGEPVILLG RDGEQEITME 350
ELGELSGRFN YELACDLSKR IPRNYLKNGE IVSQYDFFAE 390
Length:390
Mass (Da):43,825
Last modified:September 21, 2011 - v1
Checksum:i164EAB872F75BCDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012212 Genomic DNA. Translation: BAK48326.1.
RefSeqiWP_013978283.1. NC_015737.1.
YP_004709428.1. NC_015737.1.

Genome annotation databases

EnsemblBacteriaiBAK48326; BAK48326; CXIVA_23590.
GeneIDi10925732.
KEGGicls:CXIVA_23590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012212 Genomic DNA. Translation: BAK48326.1 .
RefSeqi WP_013978283.1. NC_015737.1.
YP_004709428.1. NC_015737.1.

3D structure databases

ProteinModelPortali F7V6E7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAK48326 ; BAK48326 ; CXIVA_23590 .
GeneIDi 10925732.
KEGGi cls:CXIVA_23590.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci CSP1042156:GHDR-2411-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genomic sequence of the O-desmethylangolensin-producing bacterium Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human intestine."
    Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.
    J. Bacteriol. 193:5568-5569(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SY8519.

Entry informationi

Entry nameiF7V6E7_CLOSS
AccessioniPrimary (citable) accession number: F7V6E7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: September 3, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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