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Protein

Alanine racemase

Gene

CXIVA_23590

Organism
Clostridium sp. (strain SY8519)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei39 – 391Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei269 – 2691Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei317 – 3171Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCSP1042156:GHDR-2411-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:CXIVA_23590Imported
OrganismiClostridium sp. (strain SY8519)Imported
Taxonomic identifieri1042156 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000008937 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliF7V6E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

F7V6E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAYSRVHAD IDLDAFSYNL QQIKNCRADS STKIMAVIKT DGYGHGALAL
60 70 80 90 100
SEVLEQEEDI WGYAVASVDE GKILRRAGRR KPILILGYSF PDQYEEMIDL
110 120 130 140 150
DIRTAVFSFE TARQISKAAR KLGKTAKIHI KLDTGMSRIG FSITEDSADD
160 170 180 190 200
IVSISQLPNL EIEGIFTHFA RADEKDKRFT ECQAEAFDRM IDLLMVRGLR
210 220 230 240 250
IPIHHISNSA GIIDLPQYNK DMVRAGIILY GLWPSDEVDR SRIRLKPLMS
260 270 280 290 300
IHSQVVLVKK LGPGRSISYG GTYKTSTDEV IATVPVGYGD GYPRSLSNKG
310 320 330 340 350
YVLIRGCRAP IRGRVCMDQF MVDVTHIPDV QQGEPVILLG RDGEQEITME
360 370 380 390
ELGELSGRFN YELACDLSKR IPRNYLKNGE IVSQYDFFAE
Length:390
Mass (Da):43,825
Last modified:September 21, 2011 - v1
Checksum:i164EAB872F75BCDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012212 Genomic DNA. Translation: BAK48326.1.
RefSeqiWP_013978283.1. NC_015737.1.
YP_004709428.1. NC_015737.1.

Genome annotation databases

EnsemblBacteriaiBAK48326; BAK48326; CXIVA_23590.
KEGGicls:CXIVA_23590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012212 Genomic DNA. Translation: BAK48326.1.
RefSeqiWP_013978283.1. NC_015737.1.
YP_004709428.1. NC_015737.1.

3D structure databases

ProteinModelPortaliF7V6E7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK48326; BAK48326; CXIVA_23590.
KEGGicls:CXIVA_23590.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCSP1042156:GHDR-2411-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genomic sequence of the O-desmethylangolensin-producing bacterium Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human intestine."
    Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.
    J. Bacteriol. 193:5568-5569(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SY8519Imported.

Entry informationi

Entry nameiF7V6E7_CLOSS
AccessioniPrimary (citable) accession number: F7V6E7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: April 1, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.