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F7V3H7 (F7V3H7_CLOSS) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 16. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase HAMAP-Rule MF_00022
EC=6.1.1.17 HAMAP-Rule MF_00022
Alternative name(s):
Glutamyl-tRNA synthetase HAMAP-Rule MF_00022
Gene names
Name:gltX HAMAP-Rule MF_00022
Ordered Locus Names:CXIVA_13400 EMBL BAK47306.1
OrganismClostridium sp. (strain SY8519) [Complete proteome] [HAMAP]
Taxonomic identifier1042156 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP-Rule MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP-Rule MF_00022

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00022

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP-Rule MF_00022 RuleBase RU003489

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif10 – 2011"HIGH" region By similarity HAMAP-Rule MF_00022
Motif252 – 2565"KMSKS" region By similarity HAMAP-Rule MF_00022

Sites

Binding site2551ATP By similarity HAMAP-Rule MF_00022

Sequences

Sequence LengthMass (Da)Tools
F7V3H7 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 3F2F595DB00AA25C

FASTA48355,438
        10         20         30         40         50         60 
MAKVRTRFAP SPTGRMHVGN LRTALYTYLI AKHAGGDFVL RIEDTDQGRF VAEAEDIIYH 

        70         80         90        100        110        120 
TLAETGLIHD EGPDKDGGYG PYVQSERCKS GLYMKYALEL IEKGEAYYCF CDQERLDSLK 

       130        140        150        160        170        180 
QNIGGKEISF YDKHCLHLSK EEIEANLAAG KPYVIRINVP NEGSTSFHDE IYGDISQPNE 

       190        200        210        220        230        240 
ELDDMILIKS DGYPTYNFAN VVDDHLMHIT HVVRGNEYLS SAPKYTRLYH AFGWEEPKYI 

       250        260        270        280        290        300 
HCPLITNEEH QKLSKRSGHA SYEDLVEQGF LPEAIVNFVA LLGWSPEDNQ EIMSLQELIE 

       310        320        330        340        350        360 
KFDYRHINKS PAVFDMVKLR WMNGEYLKAM DSDRFYELAE PYIKEVIHKD LDLRHIAEMV 

       370        380        390        400        410        420 
KTRIETLPEI REHIDFFEEV PAYEVSMYTH KKMKTDPEKS LALLEEVLPL LEAQEDFSND 

       430        440        450        460        470        480 
ALFAMLKAYG SEKGYKVGYV MWPIRTAVSG KQMTPGGATE LMEVLGKEES VDRIRKAIEK 


LRG

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References

[1]"Complete genomic sequence of the O-desmethylangolensin-producing bacterium Clostridium rRNA cluster XIVa strain SY8519, isolated from adult human intestine."
Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.
J. Bacteriol. 193:5568-5569(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SY8519.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP012212 Genomic DNA. Translation: BAK47306.1.
RefSeqYP_004708408.1. NC_015737.1.

3D structure databases

ProteinModelPortalF7V3H7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK47306; BAK47306; CXIVA_13400.
GeneID10925023.
KEGGcls:CXIVA_13400.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01885.

Enzyme and pathway databases

BioCycCSP1042156:GHDR-1379-MONOMER.

Family and domain databases

Gene3D1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPMF_00022_B. Glu_tRNA_synth_B.
InterProIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_Ib_bac/mito.
IPR000924. Glu/Gln-tRNA-synth_Ib.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PTHR10119:SF1. PTHR10119:SF1. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF48163. tRNA-synt_bind. 1 hit.
TIGRFAMsTIGR00464. gltX_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF7V3H7_CLOSS
AccessionPrimary (citable) accession number: F7V3H7
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: May 29, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info