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F7UXN4 (F7UXN4_EEGSY) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:DdlA EMBL BAK45795.1
Synonyms:ddl HAMAP-Rule MF_00047, ddl1 EMBL BAK45795.1
Ordered Locus Names:EGYY_28170 EMBL BAK45795.1
OrganismEggerthella sp. (strain YY7918) [Complete proteome] [HAMAP]
Taxonomic identifier502558 [NCBI]
Taxonomic lineageBacteriaActinobacteriaCoriobacteridaeCoriobacterialesCoriobacterineaeCoriobacteriaceaeEggerthella

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain122 – 326205ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding148 – 20053ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2811Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2931Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2931Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2951Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
F7UXN4 [UniParc].

Last modified September 21, 2011. Version 1.
Checksum: 8119B8B4709FEED3

FASTA32935,144
        10         20         30         40         50         60 
MGLKVAVLMG GASFEREFSL ASGKNVCAAL EEAGHKVVPL DTTSDLVPTL RSERPDVCYS 

        70         80         90        100        110        120 
ALHGKHGEDG TIQSLLEFVD IPFVGSPSSV CQRAWNKDSM HSEMAAYRAI TGDAPIAYWP 

       130        140        150        160        170        180 
QGLYIARDAF KDMGAATALD LVEERVIGGY PVCVKPAHGG SAMGVHRVDS VDQLGEAILD 

       190        200        210        220        230        240 
ALSFDEAVVI EQWIDGVEMA VSVLGTGWDA YALPPVEIVA KSGMYDTEAR MTPGAVEYFA 

       250        260        270        280        290        300 
PVRNASLAPE EADAQAIRAE IERAALEVYR AYNIRDLARI DLIWDGAQAR VFEVNVSPGM 

       310        320 
AETSLFPTAC AAAGLSLSGV LNELVSQYA 

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References

[1]"Complete genome sequence of the equol-producing bacterium Eggerthella sp. strain YY7918 isolated from adult human intestine."
Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.
Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: YY7918.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012211 Genomic DNA. Translation: BAK45795.1.
RefSeqYP_004712196.1. NC_015738.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAK45795; BAK45795; EGYY_28170.
GeneID10928304.
KEGGeyy:EGYY_28170.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycESP502558:GI1S-2554-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameF7UXN4_EEGSY
AccessionPrimary (citable) accession number: F7UXN4
Entry history
Integrated into UniProtKB/TrEMBL: September 21, 2011
Last sequence update: September 21, 2011
Last modified: June 11, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)