ID   F7UXG3_EEGSY            Unreviewed;       495 AA.
AC   F7UXG3;
DT   21-SEP-2011, integrated into UniProtKB/TrEMBL.
DT   21-SEP-2011, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
GN   OrderedLocusNames=EGYY_01770 {ECO:0000313|EMBL:BAK43421.1};
OS   Eggerthella sp. (strain YY7918).
OC   Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae;
OC   Eggerthella.
OX   NCBI_TaxID=502558 {ECO:0000313|EMBL:BAK43421.1, ECO:0000313|Proteomes:UP000008929};
RN   [1] {ECO:0000313|EMBL:BAK43421.1, ECO:0000313|Proteomes:UP000008929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YY7918 {ECO:0000313|EMBL:BAK43421.1,
RC   ECO:0000313|Proteomes:UP000008929};
RX   PubMed=21914883;
RA   Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT   "Complete Genomic Sequence of the Equol-Producing Bacterium Eggerthella sp.
RT   Strain YY7918, Isolated from Adult Human Intestine.";
RL   J. Bacteriol. 193:5570-5571(2011).
RN   [2] {ECO:0000313|Proteomes:UP000008929}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YY7918 {ECO:0000313|Proteomes:UP000008929};
RA   Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.;
RT   "Complete genome sequence of the equol-producing bacterium Eggerthella sp.
RT   strain YY7918 isolated from adult human intestine.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2;
CC         Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000018,
CC         ECO:0000256|RuleBase:RU361171};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; AP012211; BAK43421.1; -; Genomic_DNA.
DR   AlphaFoldDB; F7UXG3; -.
DR   STRING; 502558.EGYY_01770; -.
DR   KEGG; eyy:EGYY_01770; -.
DR   eggNOG; COG0076; Bacteria.
DR   HOGENOM; CLU_019582_2_2_11; -.
DR   OrthoDB; 3401800at2; -.
DR   Proteomes; UP000008929; Chromosome.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF3; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008929}.
FT   REGION          473..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         285
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   495 AA;  55871 MW;  2C37BAAD1F398D2B CRC64;
     MEQSATSKVL DSMDEGTKYL TPIFGSESSD AQMPRLTMND QPVEPRIAYE MIKEYLSIEG
     NATQNLTTFC QTYMEPMATK IMAETLEKNA IDKDEYPMTA DLENRCVAMI GDLWHANPDE
     EPMGTSTVGS SEACMLGGLA MLFRWKKLAK DAGIDIYTAQ RPNLVISAGY QVCWEKFCRY
     WDIEMRLVPL EKDHLSLNMD TVMDYVDDHT IGITAILGIT YTGKFDDVKK LDELVEAYNQ
     EHTDLPIRIH VDGASGAMVA PFVNPDLEWD FRLKNVWSIN TSGHKYGLVY PGIGWVVWRS
     KEALPEDLIF WVSYLGGEQA TMAINFSRSA SQIVGQYYVL MRNGFEGFKE IQERTLDVAR
     YLALELDEMG IFEIYEDASN IPIVCWGLKE DAGVEWSLYD LSDRLRMSGW LVPAYPMPAD
     MQDTTVQRVV ARADFSMQLA IKLVEDMKKE IDTLNKAKFV TGNTQGVIQT GFNHGGRAAV
     NHGDKEQTKA PTPQK
//