ID F7UV10_EEGSY Unreviewed; 833 AA. AC F7UV10; DT 21-SEP-2011, integrated into UniProtKB/TrEMBL. DT 21-SEP-2011, sequence version 1. DT 27-MAR-2024, entry version 61. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=EGYY_19050 {ECO:0000313|EMBL:BAK45033.1}; OS Eggerthella sp. (strain YY7918). OC Bacteria; Actinomycetota; Coriobacteriia; Eggerthellales; Eggerthellaceae; OC Eggerthella. OX NCBI_TaxID=502558 {ECO:0000313|EMBL:BAK45033.1, ECO:0000313|Proteomes:UP000008929}; RN [1] {ECO:0000313|EMBL:BAK45033.1, ECO:0000313|Proteomes:UP000008929} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YY7918 {ECO:0000313|EMBL:BAK45033.1, RC ECO:0000313|Proteomes:UP000008929}; RX PubMed=21914883; RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.; RT "Complete Genomic Sequence of the Equol-Producing Bacterium Eggerthella sp. RT Strain YY7918, Isolated from Adult Human Intestine."; RL J. Bacteriol. 193:5570-5571(2011). RN [2] {ECO:0000313|Proteomes:UP000008929} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=YY7918 {ECO:0000313|Proteomes:UP000008929}; RA Yokoyama S., Oshima K., Nomura I., Hattori M., Suzuki T.; RT "Complete genome sequence of the equol-producing bacterium Eggerthella sp. RT strain YY7918 isolated from adult human intestine."; RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP012211; BAK45033.1; -; Genomic_DNA. DR RefSeq; WP_013980277.1; NC_015738.1. DR AlphaFoldDB; F7UV10; -. DR STRING; 502558.EGYY_19050; -. DR KEGG; eyy:EGYY_19050; -. DR eggNOG; COG1793; Bacteria. DR eggNOG; COG3285; Bacteria. DR HOGENOM; CLU_008325_0_1_11; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000008929; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Reference proteome {ECO:0000313|Proteomes:UP000008929}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 309..437 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 1..32 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 508..535 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 508..525 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 833 AA; 92755 MW; A00177BF6D5F91A0 CRC64; MAAKLDEYNR KRDFTQTPEP AGSTGADPEA GTDIDGRLKF AVQHHLASHD HYDLRLEWDG ALLSWAVPKG PSFNPHDKRL AVHVEDHPLA YRTFEGTIPK GEYGGGTVML WDEGYWEPLV PVKEGLDKGD LKFILHGQRL KGAWVLVHIK PKPGERDDNW LLIKEKDSYI QPEAGIAKFN ASVSTGRTMD EIARGEDERF AQNPFDKVNV ELAKLVNAVP PGDEWLYEVK YDGYRIVAFV EASQARLITR NHHDYTDHFP TLANSLAEWA AGRAMVLDGE VVVTDEAGRS DFQALQNFLR HPAGKQPLYM VFDLLALDGD DLRTLPLGER KERLETLLND APEEVRYSVH VRGHGAESFH AACSQRLEGV VGKRADAPYH GTRNGDWIKL KCDKRQEFVV GGWTRTAKKS DGVSSLLLGA YENGTLVYVG RVGSGIGEDD ARELLAKFVG LERSAAPFVN PPKARSGEKS FWLEPALVAE VKFAEWTDDG QLRHPSYQGL RVDKDPRAVI REDPSDIEQP PPPTERKKDP MPATTASFIP ATPAHATGDL VIDGVTITSS DKLLFKDPDV TKGDVVRYYA QVADAMLPYT SGRILSIVRC PRGAGSACFF KKHPGPHEKG IHAIDVTGSD GEQDEYFYVD DAVGIVSEAQ MDTLEFHLWG SRVETLEQPD MMVFDLDPDK SLGLDLVRRG VRDLKSILDD LGLQTFLKTS GGKGYHVVIP LQPEASWDAF HDFARRIAQV MAEKWPDRYT SNVRLAKRNG KIFIDWMRNG RGATSIAPYS LRARSGARVS MPISWDELDD VAPDAVTMAD ALARLARGDN PWKGYFDVKQ SLR //