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Protein

Superoxide dismutase [Cu-Zn]

Gene

SOD3

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:SOD3Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500336091319 – 240Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST222

Expressioni

Gene expression databases

BgeeiENSMMUG00000002612

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000003508

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 210Sod_CuInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
InParanoidiF7H9D9
KOiK16627
OMAiEQEDDMG
OrthoDBiEOG091G13ID
TreeFamiTF105133

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

F7H9D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLALLCSCLL LAAGASDAWT GKDSAEPNSD LAESIRDMHA KITEIWQELT
60 70 80 90 100
QRRDGDGALH AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLEAFFALE
110 120 130 140 150
GFPTQPNNSS RAIHVHQFGD LSQGCESTGP HYNPLAVPHP RHPGDFGNFA
160 170 180 190 200
VRDGSLWKYR AGLAASLAGP HSIVGRAVVV HAGEDDLGRG GNQASVENGN
210 220 230 240
AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAV
Length:240
Mass (Da):25,759
Last modified:July 27, 2011 - v1
Checksum:i12888ED6C4DD97EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03033069 Genomic DNA No translation available.
RefSeqiNP_001181261.1, NM_001194332.2
UniGeneiMmu.18365

Genome annotation databases

EnsembliENSMMUT00000003714; ENSMMUP00000003508; ENSMMUG00000002612
GeneIDi715931
KEGGimcc:715931

Similar proteinsi

Entry informationi

Entry nameiF7H9D9_MACMU
AccessioniPrimary (citable) accession number: F7H9D9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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