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Protein
Submitted name:

Neuroendocrine convertase 2 isoform 1 preproprotein

Gene

PCSK2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.073.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 2 isoform 1 preproproteinImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:PCSK2Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMMUG00000014626.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000019197.

Structurei

3D structure databases

ProteinModelPortaliH9FVD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 90S8_pro-domainInterPro annotationAdd BLAST77
Domaini139 – 401Peptidase S8InterPro annotationAdd BLAST263
Domaini485 – 571P_proproteinInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
KOG3526. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
InParanoidiF7GNE5.
KOiK01360.
OMAiTDACQGK.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7GNE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDEARQVA
60 70 80 90 100
AEHGFGVRKL PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ
110 120 130 140 150
QEGFDRKKRG YRDINEIDIN MNDPLFTKQW YLINTGQADG TPGLDLNVAE
160 170 180 190 200
AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY
210 220 230 240 250
TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM LDQPFMTDII
260 270 280 290 300
EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
310 320 330 340 350
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST
360 370 380 390 400
LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA
410 420 430 440 450
NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG
460 470 480 490 500
AMVKMAKDWK TVPERFHCVG GSVQDPEKIP STGKLVLTLT TDACEGKENF
510 520 530 540 550
VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP RDDDSKVGFD
560 570 580 590 600
KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
610 620 630
DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILSKN
Length:638
Mass (Da):70,539
Last modified:November 30, 2016 - v2
Checksum:i789B1CDEFD32F396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03004819 Genomic DNA. No translation available.
JU334839 mRNA. Translation: AFE78592.1.
RefSeqiNP_001252954.1. NM_001266025.1.
UniGeneiMmu.34008.

Genome annotation databases

EnsembliENSMMUT00000020512; ENSMMUP00000019197; ENSMMUG00000014626.
GeneIDi695730.
KEGGimcc:695730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03004819 Genomic DNA. No translation available.
JU334839 mRNA. Translation: AFE78592.1.
RefSeqiNP_001252954.1. NM_001266025.1.
UniGeneiMmu.34008.

3D structure databases

ProteinModelPortaliH9FVD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000019197.

Protein family/group databases

MEROPSiS08.073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000020512; ENSMMUP00000019197; ENSMMUG00000014626.
GeneIDi695730.
KEGGimcc:695730.

Organism-specific databases

CTDi5126.

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
KOG3526. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
InParanoidiF7GNE5.
KOiK01360.
OMAiTDACQGK.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Gene expression databases

BgeeiENSMMUG00000014626.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Propept_inh.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF16470. S8_pro-domain. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF7GNE5_MACMU
AccessioniPrimary (citable) accession number: F7GNE5
Secondary accession number(s): H9FVD3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: November 30, 2016
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.