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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 1

Gene

PCSK1

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:PCSK1Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 25HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMODG00000020079.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000025096.

Structurei

3D structure databases

ProteinModelPortaliF7GI61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini460 – 597P/Homo BInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
InParanoidiF7GI61.
KOiK01359.
OMAiFEPRALK.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di2.60.120.260. 1 hit.
3.30.70.850. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like_sf.
IPR034182. Kexin/furin.
IPR002884. P_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR036852. Peptidase_S8/S53_dom_sf.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR032815. S8_pro-domain.
IPR038466. S8_pro-domain_sf.
PfamiView protein in Pfam
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
PROSITEiView protein in PROSITE
PS51829. P_HOMO_B. 1 hit.
PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

F7GI61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRCWSLQY IAFALYFCWW AMYSVRAEKQ FVNEWAAEIP GGLNSAREIA
60 70 80 90 100
EELGYDLLGQ IGSLENHYLF RHKNHPRRSR RSAIHITKRL SDDDRVTWAE
110 120 130 140 150
QQYGKERNKR SILRDSAEDL FNDPMWNQQW YLQDTRMTPV LPKLDLHVIP
160 170 180 190 200
VWQKGITGKG VVITVLDDGL EWNHTDIFAN YDPEASYDFN DNDRDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNQKCGVGVA YNSKVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPDH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GIKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDDCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATAYSSGDY TDQRITSADL HDDCTETHTG TSASAPLAAG IFALALEANP
410 420 430 440 450
HLTWRDMQHL VVWTSEYDPL AINPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPKTWKG VPEKKECIVK DNNFEPKSLK ADGVVTIEIP TKACEGQENS
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPVGTWALR ITDMSGRMQN EGRIVNWKLI LHGTATQPEH
610 620 630 640 650
MKQPRVYTSY NAVQNDRRGV EKMADSVKDR AILENLPEGS QLSRISTTPS
660 670 680 690 700
TGSDSVKGDK LMEKTLSRAM LQLLQSAFSK QGAPNQAPKS EPSEKLKIPY
710 720 730 740 750
EHFYQALEKL NKPSQLKNDE NSLYSDYVDL FYNTKPYKHR DDRLLQALVD

ILKEGN
Length:756
Mass (Da):84,816
Last modified:July 27, 2011 - v1
Checksum:i6657A622291C2674
GO

Sequence databases

RefSeqiXP_001364000.1. XM_001363963.3.

Genome annotation databases

EnsembliENSMODT00000025539; ENSMODP00000025096; ENSMODG00000020079.
GeneIDi100010673.
KEGGimdo:100010673.

Similar proteinsi

Entry informationi

Entry nameiF7GI61_MONDO
AccessioniPrimary (citable) accession number: F7GI61
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported