Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kit ligand

Gene

KITLG

Organism
Callithrix jacchus (White-tufted-ear marmoset)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Kit ligandUniRule annotation
Alternative name(s):
c-Kit ligandUniRule annotation
Gene namesi
Name:KITLGImported
OrganismiCallithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifieri9483 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeCallitrichinaeCallithrixCallithrix
Proteomesi
  • UP000008225 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei178 – 202HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 128UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Subunit structurei

Homodimer, non-covalently linked.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili218 – 238Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the SCF family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF3Y. Eukaryota.
ENOG410XYQR. LUCA.
GeneTreeiENSGT00390000018272.

Family and domain databases

InterProiView protein in InterPro
IPR009079. 4_helix_cytokine-like_core.
IPR003452. SCF.
PANTHERiPTHR11574. PTHR11574. 1 hit.
PfamiView protein in Pfam
PF02404. SCF. 1 hit.
PIRSFiPIRSF015599. SCF. 1 hit.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

F7GD96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSCLAAQVA NLPKDYMITL KYVPGMDVLP SHCWISEMVV QLSSSLTDLL
60 70 80 90 100
DKFSNISEGL SNYSIIDKLV NIVDDLVECV KENSSKDLKK PFKSPEPRLF
110 120 130 140 150
TPEEFFRIFN RSIDAFKDFV VASETSDCMA SSTLSPEKDS RVSVTKPFML
160 170 180 190 200
PSVAANSLRN DSSSSNRKAK NPPGDSGLHW AAMALPALFS LIIGFAFGAL
210 220 230
YWKKRQPSLT RTVENIQINE EDNEISMLQE KEREFQEV
Length:238
Mass (Da):26,670
Last modified:July 27, 2011 - v1
Checksum:i434C2EE1E4471B73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ACFV01026536 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSCJAT00000038586; ENSCJAP00000036530; ENSCJAG00000019661.

Similar proteinsi

Entry informationi

Entry nameiF7GD96_CALJA
AccessioniPrimary (citable) accession number: F7GD96
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: December 20, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported