F7GD21 (F7GD21_ORNAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ribonuclease RuleBase RU003515
EC=3.1.26.- RuleBase RU003515

Gene names

Name:

RNASEH2A Ensembl ENSOANP00000014455

Organism

Ornithorhynchus anatinus (Duckbill platypus) [Reference proteome] Ensembl ENSOANP00000014455

Taxonomic identifier

9258 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Prototheria › Monotremata › Ornithorhynchidae › Ornithorhynchus

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Endonuclease that specifically degrades the RNA of RNA-DNA hybrids By similarity. RuleBase RU003515
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. RuleBase RU003515
Sequence similarities	Belongs to the RNase HII family. RuleBase RU003515
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSOANP00000014455

Ontologies

Keywords
Molecular function	Endonuclease RuleBase RU003515 Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	RNA catabolic process Inferred from electronic annotation. Source: Compara nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	ribonuclease H2 complex Inferred from electronic annotation. Source: Compara
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease H activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F7GD21 [UniParc]. Last modified July 27, 2011. Version 1. Checksum: 358594F0682FE794	FASTA	300	33,700
	10 20 30 40 50 60 MDLGDFERDN TGSCRLSSPV PELCPNRRVL PGQSMSRPGF PCWVEGDCFC PLSRQGDLTA 70 80 90 100 110 120 LKVADSKTLT ESERERLFGK LDAAREFVGW ALEVLSPNLI STSMQRRAKY NLNALSHDTA 130 140 150 160 170 180 MALVQHALDM GVRVTQVFVD TVGPAEKYQE KLKQRFPELE VTVKPKADSL FPVVSAASIC 190 200 210 220 230 240 AKVARDLVVK NWRFLEDLGD GNMDYGSGYP NDPKTKEWLS QNLDPVFGFP QFVRFSWSTA 250 260 270 280 290 300 QTILDREAVP VREDAEEEEG ASSRKGTPSL LAFFARKDGP AQRQPHRFFH ERRLESITNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome analysis of the platypus reveals unique signatures of evolution." Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L., Fulton B. , Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P., Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D., Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A., Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K. Nature 453:175-183(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Glennie Ensembl ENSOANP00000014455.
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Glennie Ensembl ENSOANP00000014455.

Cross-references

3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSOANT00000014458; ENSOANP00000014455; ENSOANG00000009079.
Phylogenomic databases
GeneTree	ENSGT00390000010768.
OMA	NWRFLED.
Family and domain databases
Gene3D	1.10.10.460. 1 hit.
InterPro	IPR004649. RNase_H2_suA. IPR001352. RNase_HII/HIII. IPR024567. RNase_HII/HIII_dom. IPR023160. RNase_HII_hlx-loop-hlx_cap_dom. IPR012337. RNaseH-like_dom. [Graphical view]
PANTHER	PTHR10954. PTHR10954. 1 hit.
Pfam	PF01351. RNase_HII. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
TIGRFAMs	TIGR00729. TIGR00729. 1 hit.
ProtoNet	Search...

Entry information

Entry name

F7GD21_ORNAN

Accession

Primary (citable) accession number: F7GD21

Entry history

Integrated into UniProtKB/TrEMBL:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	March 6, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)