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Protein

Histone deacetylase

Gene

HDAC6

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1129 – 1190UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:HDAC6Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMMUG00000016465.
ExpressionAtlasiF7GBF5. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000021637.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1129 – 1190UBP-typeInterPro annotationAdd BLAST62

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1129 – 1190UBP-typePROSITE-ProRule annotationAdd BLAST62

Phylogenomic databases

eggNOGiKOG1343. Eukaryota.
COG0123. LUCA.
GeneTreeiENSGT00530000062809.
InParanoidiF7GBF5.
OrthoDBiEOG091G0210.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
PRINTSiPR01270. HDASUPER.
SMARTiView protein in SMART
SM00290. ZnF_UBP. 1 hit.
PROSITEiView protein in PROSITE
PS50271. ZF_UBP. 1 hit.

Sequencei

Sequence statusi: Complete.

F7GBF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV
60 70 80 90 100
KKKGKMKKLG QAMEEDLIAG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL
110 120 130 140 150
WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI
160 170 180 190 200
DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG
210 220 230 240 250
AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV
260 270 280 290 300
DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG
310 320 330 340 350
QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG
360 370 380 390 400
DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEVSDSPSP KGVPGPAFHL
410 420 430 440 450
LAGQPCISHF TSFAQASVSC ALEALEPFWE VLVRSSRKWA ETVEGDNMEE
460 470 480 490 500
DNVEENEEEG PWEPPVLPIL TWPVLQSRTG LVYDQSMMNH CNLWDSHHPE
510 520 530 540 550
VPQRILRIMC RLEELGLAGR CLTLTPRPAT EAELLTCHSA EYVGHLRATE
560 570 580 590 600
KMKTRELHRE SSNFDSIYIC PSTFACAQLA TGAACRLVEA VLSGEVLNGA
610 620 630 640 650
AVVRPPGHHA EQDAACGFCF FNSVAVAARH AQAISGRALR ILIVDWDVHH
660 670 680 690 700
GNGTQHMFED DPSVLYVSLH RYDHGTFFPM GDEGASSQIG RAAGTGFTVN
710 720 730 740 750
VAWNGPRMGD ADYLAAWHRL VLPIAYEFNP ELVLVSAGFD AARGDPLGGC
760 770 780 790 800
QVSPEGYAHL THLLMGLASG RIILILEGGY NLTSISESMA ACTRSLLGDP
810 820 830 840 850
PPLLTLPRPP LSGALASITE TIQVHRRYWR SLRVMKVEDR EGPSSSKLVT
860 870 880 890 900
KKAPQPAKPR LAERMTTREK KVLEAGMGKI TSASSGEEST PGQTKSETAV
910 920 930 940 950
VALTQDQSSE AATGGATLAQ TISEAAVGGA MLGQTTSEEA VGGATPDQTT
960 970 980 990 1000
SEKTVGGATL DQTTSEDAVG GATLGQTTSE EAVGGATLAQ TTSEAAMEGA
1010 1020 1030 1040 1050
TLDQTTSEEA PGGTELIQTP LASSTDHQTP PTSPVQGTTP QISPSTLIEN
1060 1070 1080 1090 1100
LRTLELGSKS QGASESQAPG EENLLGEAAG GQDMADSMLM QGSRGLTDQA
1110 1120 1130 1140 1150
IFYAVTPLPW CPHLVAVCPI PAAGLDVTQP CGDCGTIQEN WVCLSCYQVY
1160 1170 1180 1190 1200
CGRYINGHML QHHENSGHPL VLSYIDLSTW CYYCQAYVHH QALLDVKNIA
1210
HQNKFGEDMP HPH
Length:1,213
Mass (Da):131,380
Last modified:November 30, 2016 - v2
Checksum:iD561E31218265D37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03045524 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMMUT00000023129; ENSMMUP00000021637; ENSMMUG00000016465.

Similar proteinsi

Entry informationi

Entry nameiF7GBF5_MACMU
AccessioniPrimary (citable) accession number: F7GBF5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: August 30, 2017
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported