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F7GBF5

- F7GBF5_MACMU

UniProt

F7GBF5 - F7GBF5_MACMU

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Protein
Submitted name:

Uncharacterized protein

Gene

HDAC6

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: Ensembl
  2. tubulin deacetylase activity Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. aggresome assembly Source: Ensembl
  2. cellular response to hydrogen peroxide Source: Ensembl
  3. cellular response to misfolded protein Source: Ensembl
  4. Hsp90 deacetylation Source: Ensembl
  5. lysosome localization Source: Ensembl
  6. macroautophagy Source: Ensembl
  7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  8. negative regulation of microtubule depolymerization Source: Ensembl
  9. negative regulation of proteolysis Source: Ensembl
  10. peptidyl-lysine deacetylation Source: Ensembl
  11. polyubiquitinated misfolded protein transport Source: Ensembl
  12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  15. positive regulation of receptor biosynthetic process Source: Ensembl
  16. positive regulation of signal transduction Source: Ensembl
  17. protein complex disassembly Source: Ensembl
  18. protein polyubiquitination Source: Ensembl
  19. regulation of establishment of protein localization Source: Ensembl
  20. regulation of receptor activity Source: Ensembl
  21. response to growth factor Source: Ensembl
  22. response to toxic substance Source: Ensembl
  23. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:HDAC6Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome X

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. axon Source: Ensembl
  3. caveola Source: Ensembl
  4. cell leading edge Source: Ensembl
  5. cytoplasmic microtubule Source: Ensembl
  6. cytosol Source: Ensembl
  7. dendrite Source: Ensembl
  8. dynein complex Source: Ensembl
  9. histone deacetylase complex Source: Ensembl
  10. perikaryon Source: Ensembl
  11. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiF7GBF5. baseline.

Structurei

3D structure databases

ProteinModelPortaliF7GBF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
InParanoidiF7GBF5.
KOiK11407.
OMAiLQENWVC.
OrthoDBiEOG7992PT.
TreeFamiTF106173.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7GBF5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGGNRGRGQ ASSTMTSTGQ DSTTTRQRRS RQNPQSPPQD SSVTSKRNIK
60 70 80 90 100
KGAVPRSIPN LAEVKKKGKM KKLGQAMEED LIAGLQGMDL NLEAEALAGT
110 120 130 140 150
GLVLDEQLNE FHCLWDDSFP EGPERLHAIK EQLIQEGLLD RCVSFQARFA
160 170 180 190 200
EKEELMLVHS LEYIDLMETT QYMNEGELRV LADTYDSVYL HPNSYSCACL
210 220 230 240 250
ASGSVLRLVD AVLGAEIRNG MAIIRPPGHH AQHSLMDGYC MFNHVAVAAR
260 270 280 290 300
YAQQKHRIRR VLIVDWDVHH GQGTQFTFDQ DPSVLYFSIH RYEQGRFWPH
310 320 330 340 350
LKASNWSTTG FGQGQGYTIN VPWNQVGMRD ADYIAAFLHV LLPVALEFQP
360 370 380 390 400
QLVLVAAGFD ALQGDPKGEM AATPAGFAQL THLLMGLAGG KLILSLEGGY
410 420 430 440 450
NLRALAEGVS ASLHTLLGDP CPMLESPGAP CRSAQASVSC ALEALEPFWE
460 470 480 490 500
VLVRSTETVE GDNMEEDNVE ENEEEGPWEP PVLPILTWPV LQSRTGLVYD
510 520 530 540 550
QSMMNHCNLW DSHHPEVPQR ILRIMCRLEE LGLAGRCLTL TPRPATEAEL
560 570 580 590 600
LTCHSAEYVG HLRATEKMKT RELHRESSNF DSIYICPSTF ACAQLATGAA
610 620 630 640 650
CRLVEAVLSG EVLNGAAVVR PPGHHAEQDA ACGFCFFNSV AVAARHAQAI
660 670 680 690 700
SGRALRILIV DWDVHHGNGT QHMFEDDPSV LYVSLHRYDH GTFFPMGDEG
710 720 730 740 750
ASSQIGRAAG TGFTVNVAWN GPRMGDADYL AAWHRLVLPI AYEFNPELVL
760 770 780 790 800
VSAGFDAARG DPLGGCQVSP EGYAHLTHLL MGLASGRIIL ILEGGYNLTS
810 820 830 840 850
ISESMAACTR SLLGDPPPLL TLPRPPLSGA LASITETIQV HRRYWRSLRV
860 870 880 890 900
MKVEDREGPS SSKLVTKKAP QPAKPRLAER MTTREKKVLE AGMGKITSAS
910 920 930 940 950
SGEESTPGQT KSETAVVALT QDQSSEAATG GATLAQTISE AAVGGAMLGQ
960 970 980 990 1000
TTSEEAVGGA TPDQTTSEKT VGGATLDQTT SEDAVGGATL GQTTSEEAVG
1010 1020 1030 1040 1050
GATLAQTTSE AAMEGATLDQ TTSEEAPGGT ELIQTPLASS TDHQTPPTSP
1060 1070 1080 1090 1100
VQGTTPQISP STLIENLRTL ELGSKSQGAS ESQAPGEENL LGEAAGGQDM
1110 1120 1130 1140 1150
ADSMLMQGSR GLTDQAIFYA VTPLPWCPHL VAVCPIPAAG LDVTQPCGDC
1160 1170 1180 1190 1200
GTIQENWVCL SCYQVYCGRY INGHMLQHHE NSGHPLVLSY IDLSTWCYYC
1210 1220
QAYVHHQALL DVKNIAHQNK FGEDMPHPH
Length:1,229
Mass (Da):132,829
Last modified:July 27, 2011 - v1
Checksum:i65D90AAC97408AEC
GO

Sequence databases

RefSeqiXP_001101619.1. XM_001101619.2.
UniGeneiMmu.18720.

Genome annotation databases

EnsembliENSMMUT00000023129; ENSMMUP00000021637; ENSMMUG00000016465.
GeneIDi711363.
KEGGimcc:711363.

Cross-referencesi

Sequence databases

RefSeqi XP_001101619.1. XM_001101619.2.
UniGenei Mmu.18720.

3D structure databases

ProteinModelPortali F7GBF5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000023129 ; ENSMMUP00000021637 ; ENSMMUG00000016465 .
GeneIDi 711363.
KEGGi mcc:711363.

Organism-specific databases

CTDi 10013.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
InParanoidi F7GBF5.
KOi K11407.
OMAi LQENWVC.
OrthoDBi EOG7992PT.
TreeFami TF106173.

Miscellaneous databases

NextBioi 19972529.

Gene expression databases

ExpressionAtlasi F7GBF5. baseline.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary and biomedical insights from the rhesus macaque genome."
    Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., Makova K.D., Miller W., Milosavljevic A.
    , Palermo R.E., Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., Zwieg A.S.
    Science 316:222-234(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 17573Imported.
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: 17573Imported.

Entry informationi

Entry nameiF7GBF5_MACMU
AccessioniPrimary (citable) accession number: F7GBF5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3