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F7GBF5

- F7GBF5_MACMU

UniProt

F7GBF5 - F7GBF5_MACMU

Protein
Submitted name:

Uncharacterized protein

Gene

HDAC6

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: Ensembl
    2. tubulin deacetylase activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. aggresome assembly Source: Ensembl
    2. cellular response to hydrogen peroxide Source: Ensembl
    3. cellular response to misfolded protein Source: Ensembl
    4. Hsp90 deacetylation Source: Ensembl
    5. lysosome localization Source: Ensembl
    6. macroautophagy Source: Ensembl
    7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
    8. negative regulation of microtubule depolymerization Source: Ensembl
    9. negative regulation of proteolysis Source: Ensembl
    10. peptidyl-lysine deacetylation Source: Ensembl
    11. polyubiquitinated misfolded protein transport Source: Ensembl
    12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
    13. positive regulation of epithelial cell migration Source: Ensembl
    14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
    15. positive regulation of receptor biosynthetic process Source: Ensembl
    16. positive regulation of signal transduction Source: Ensembl
    17. protein complex disassembly Source: Ensembl
    18. protein polyubiquitination Source: Ensembl
    19. regulation of establishment of protein localization Source: Ensembl
    20. regulation of receptor activity Source: Ensembl
    21. response to growth factor Source: Ensembl
    22. response to toxic substance Source: Ensembl
    23. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Uncharacterized proteinImported
    Gene namesi
    Name:HDAC6Imported
    OrganismiMacaca mulatta (Rhesus macaque)Imported
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome X

    Subcellular locationi

    GO - Cellular componenti

    1. aggresome Source: Ensembl
    2. caveola Source: Ensembl
    3. cell leading edge Source: Ensembl
    4. cytoplasmic microtubule Source: Ensembl
    5. cytosol Source: Ensembl
    6. dynein complex Source: Ensembl
    7. histone deacetylase complex Source: Ensembl
    8. perinuclear region of cytoplasm Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliF7GBF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062809.
    KOiK11407.
    OMAiLQENWVC.
    OrthoDBiEOG7992PT.
    TreeFamiTF106173.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.40.800.20. 2 hits.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 2 hits.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.
    SMARTiSM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7GBF5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGGNRGRGQ ASSTMTSTGQ DSTTTRQRRS RQNPQSPPQD SSVTSKRNIK     50
    KGAVPRSIPN LAEVKKKGKM KKLGQAMEED LIAGLQGMDL NLEAEALAGT 100
    GLVLDEQLNE FHCLWDDSFP EGPERLHAIK EQLIQEGLLD RCVSFQARFA 150
    EKEELMLVHS LEYIDLMETT QYMNEGELRV LADTYDSVYL HPNSYSCACL 200
    ASGSVLRLVD AVLGAEIRNG MAIIRPPGHH AQHSLMDGYC MFNHVAVAAR 250
    YAQQKHRIRR VLIVDWDVHH GQGTQFTFDQ DPSVLYFSIH RYEQGRFWPH 300
    LKASNWSTTG FGQGQGYTIN VPWNQVGMRD ADYIAAFLHV LLPVALEFQP 350
    QLVLVAAGFD ALQGDPKGEM AATPAGFAQL THLLMGLAGG KLILSLEGGY 400
    NLRALAEGVS ASLHTLLGDP CPMLESPGAP CRSAQASVSC ALEALEPFWE 450
    VLVRSTETVE GDNMEEDNVE ENEEEGPWEP PVLPILTWPV LQSRTGLVYD 500
    QSMMNHCNLW DSHHPEVPQR ILRIMCRLEE LGLAGRCLTL TPRPATEAEL 550
    LTCHSAEYVG HLRATEKMKT RELHRESSNF DSIYICPSTF ACAQLATGAA 600
    CRLVEAVLSG EVLNGAAVVR PPGHHAEQDA ACGFCFFNSV AVAARHAQAI 650
    SGRALRILIV DWDVHHGNGT QHMFEDDPSV LYVSLHRYDH GTFFPMGDEG 700
    ASSQIGRAAG TGFTVNVAWN GPRMGDADYL AAWHRLVLPI AYEFNPELVL 750
    VSAGFDAARG DPLGGCQVSP EGYAHLTHLL MGLASGRIIL ILEGGYNLTS 800
    ISESMAACTR SLLGDPPPLL TLPRPPLSGA LASITETIQV HRRYWRSLRV 850
    MKVEDREGPS SSKLVTKKAP QPAKPRLAER MTTREKKVLE AGMGKITSAS 900
    SGEESTPGQT KSETAVVALT QDQSSEAATG GATLAQTISE AAVGGAMLGQ 950
    TTSEEAVGGA TPDQTTSEKT VGGATLDQTT SEDAVGGATL GQTTSEEAVG 1000
    GATLAQTTSE AAMEGATLDQ TTSEEAPGGT ELIQTPLASS TDHQTPPTSP 1050
    VQGTTPQISP STLIENLRTL ELGSKSQGAS ESQAPGEENL LGEAAGGQDM 1100
    ADSMLMQGSR GLTDQAIFYA VTPLPWCPHL VAVCPIPAAG LDVTQPCGDC 1150
    GTIQENWVCL SCYQVYCGRY INGHMLQHHE NSGHPLVLSY IDLSTWCYYC 1200
    QAYVHHQALL DVKNIAHQNK FGEDMPHPH 1229
    Length:1,229
    Mass (Da):132,829
    Last modified:July 27, 2011 - v1
    Checksum:i65D90AAC97408AEC
    GO

    Sequence databases

    RefSeqiXP_001101619.1. XM_001101619.2.
    UniGeneiMmu.18720.

    Genome annotation databases

    EnsembliENSMMUT00000023129; ENSMMUP00000021637; ENSMMUG00000016465.
    GeneIDi711363.
    KEGGimcc:711363.

    Cross-referencesi

    Sequence databases

    RefSeqi XP_001101619.1. XM_001101619.2.
    UniGenei Mmu.18720.

    3D structure databases

    ProteinModelPortali F7GBF5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000023129 ; ENSMMUP00000021637 ; ENSMMUG00000016465 .
    GeneIDi 711363.
    KEGGi mcc:711363.

    Organism-specific databases

    CTDi 10013.

    Phylogenomic databases

    GeneTreei ENSGT00530000062809.
    KOi K11407.
    OMAi LQENWVC.
    OrthoDBi EOG7992PT.
    TreeFami TF106173.

    Miscellaneous databases

    NextBioi 19972529.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.40.800.20. 2 hits.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 2 hits.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    SMARTi SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary and biomedical insights from the rhesus macaque genome."
      Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M., Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C., Makova K.D., Miller W., Milosavljevic A.
      , Palermo R.E., Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J., Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E., Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J., Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J., Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A., Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E., Zwieg A.S.
      Science 316:222-234(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 17573Imported.
    2. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: 17573Imported.

    Entry informationi

    Entry nameiF7GBF5_MACMU
    AccessioniPrimary (citable) accession number: F7GBF5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3