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Protein

Voltage-dependent P/Q-type calcium channel subunit alpha

Gene

CACNA1A

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent P/Q-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:CACNA1AImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei216 – 235HelicalSequence analysisAdd BLAST20
Transmembranei294 – 315HelicalSequence analysisAdd BLAST22
Transmembranei327 – 349HelicalSequence analysisAdd BLAST23
Transmembranei465 – 484HelicalSequence analysisAdd BLAST20
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Transmembranei591 – 613HelicalSequence analysisAdd BLAST23
Transmembranei667 – 691HelicalSequence analysisAdd BLAST25
Transmembranei1223 – 1242HelicalSequence analysisAdd BLAST20
Transmembranei1262 – 1283HelicalSequence analysisAdd BLAST22
Transmembranei1295 – 1312HelicalSequence analysisAdd BLAST18
Transmembranei1357 – 1379HelicalSequence analysisAdd BLAST23
Transmembranei1469 – 1494HelicalSequence analysisAdd BLAST26
Transmembranei1550 – 1568HelicalSequence analysisAdd BLAST19
Transmembranei1580 – 1603HelicalSequence analysisAdd BLAST24
Transmembranei1671 – 1689HelicalSequence analysisAdd BLAST19
Transmembranei1767 – 1791HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMMUG00000003555
ExpressionAtlasiF7ETU0 baseline

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000004738

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1928 – 1962Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili357 – 377Sequence analysisAdd BLAST21
Coiled coili706 – 726Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
GeneTreeiENSGT00830000128247
InParanoidiF7ETU0
OrthoDBiEOG091G0TKO
TreeFamiTF312805

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR005448 CACNA1A
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01632 PQVDCCALPHA1
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

Sequencei

Sequence statusi: Complete.

F7ETU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFGDEMPA RYGGGGSGAA AGVVVGAGGG RGAGGSRQGG QPGAQRMYKQ
60 70 80 90 100
SMAQRARTMA LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPYP
110 120 130 140 150
FARTPAAAQH LPDDDKTPMS ERLDDTEPYF IGIFCFEAGI KIIALGFAFH
160 170 180 190 200
KGSYLRNGWN VMDFVVVLTG ILATVGTEFD LRTLRAVRVL RPLKLVSGIP
210 220 230 240 250
SLQVVLKSIM KAMIPLLQIG LLLFFAILIF AIIGLEFYMG KFHTTCFEEG
260 270 280 290 300
TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ FDNILFAVLT
310 320 330 340 350
VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS
360 370 380 390 400
GEFAKERERV ENRRAFLKLR RQQQIERELN GYMEWISKAG EALSSRALRR
410 420 430 440 450
ATIKKSKTDL LNPEEAEDQL ADIASVGSPF ARASIKSAKL ENSTFFHKKE
460 470 480 490 500
RRMRFYIRRM VKTQAFYWTV LSLVALNTLC VAIVHYNQPE WLSDFLYYAE
510 520 530 540 550
FIFLGLFMSE MFIKMYGLGT RPYFHSSFNC FDCGVIIGSI FEVIWAVIKP
560 570 580 590 600
GTSFGISVLR ALRLLRIFKV TKYWASLRNL VVSLLNSMKS IISLLFLLFL
610 620 630 640 650
FIVVFALLGM QLFGGQFNFD EGTPPTNFDT FPAAIMTVFQ ILTGEDWNEV
660 670 680 690 700
MYDGIKSQGG VQGGMVFSIY FIVLTLFGNY TLLNVFLAIA VDNLANAQEL
710 720 730 740 750
TKVEGDEQEE EEAANQKLAL QKAKEVAEVS PLSAANMSIA MKEQQKNQKP
760 770 780 790 800
AKSVWEQRTS EMRKQNLLAS REALYNEMDP DERWKAAYTR HLRPDMKTHL
810 820 830 840 850
DRPLVVDPQE NRNNNTNKSR AAEPTVDQRL GQQRAEDFLR KQARYHDRAR
860 870 880 890 900
DPSGSAGLDA RRPWAGSQEA ELSREGPYGR ESDHHAREGS LEQPGFWEGE
910 920 930 940 950
AERGKAGDPH RRHVHRQGGS RESRSGSPRT GADGEPRRHR GHRRPGEEGP
960 970 980 990 1000
EDKAERRARH REGSRPARGG EGEGEGPDGG ERRRRHRHGA PATYEGDPRR
1010 1020 1030 1040 1050
EDKERRHRRR KENQGSGVPV SGPNLSTTRP IQQDLGRQDP PLAEDIDNMK
1060 1070 1080 1090 1100
NNKLATAESA GPHDSLGHAG LPQSPAKMGN STDPGPTPAI PAMATNPQNA
1110 1120 1130 1140 1150
ASRRMPNNPG NPSNPGPPKT PENSLIVTNP SGTQTNSAKT ARKPDHTTVD
1160 1170 1180 1190 1200
IPPACPPPLN HTVVQVNKNA NPDPLPKKED EKKEEEEDDR GEDGPKPMPP
1210 1220 1230 1240 1250
YSSMFILSTT NPLRRLCHYI LNLRYFEMCI LMVIAMSSIA LAAEDPVQPN
1260 1270 1280 1290 1300
APRNNVLRYF DYVFTGVFTF EMVIKMIDLG LVLHQGAYFR DLWNILDFIV
1310 1320 1330 1340 1350
VSGALVAFAF TGNSKGKDIN TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV
1360 1370 1380 1390 1400
VNSLKNVFNI LIVYMLFMFI FAVVAVQLFK GKFFHCTDES KEFEKDCRGK
1410 1420 1430 1440 1450
YLLYEKNEVK ARDREWKKYE FHYDNVLWAL LTLFTVSTGE GWPQVLKHSV
1460 1470 1480 1490 1500
DATFENQGPS PGYRMEMSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK
1510 1520 1530 1540 1550
MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ NKQSFQYRMW QFVVSPPFEY
1560 1570 1580 1590 1600
TIMAMIALNT IVLMMKFYGA SVAYENALRV FNIVFTSLFS LECVLKVMAF
1610 1620 1630 1640 1650
GILNYFRDAW NIFDFVTVLG SITDILVTEF GNNFINLSFL RLFRAARLIK
1660 1670 1680 1690 1700
LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA MLFFIYAIIG MQVFGNIGID
1710 1720 1730 1740 1750
VEDEDSDEDE FQITEHNNFR TFFQALMLLF RSATGEAWHN IMLSCLSGKP
1760 1770 1780 1790 1800
CDKNSGILTR ECGNEFAYFY FVSFIFLCSF LMLNLFVAVI MDNFEYLTRD
1810 1820 1830 1840 1850
SSILGPHHLD EYVRVWAEYD PAAWGRMPYL DMYQMLRHMS PPLGLGKKCP
1860 1870 1880 1890 1900
ARVAYKRLLR MDLPVADDNT VHFNSTLMAL IRTALDIKIA KGGADKQQMD
1910 1920 1930 1940 1950
AELRKEMMAI WPNLSQKTLD LLVTPHKSTD LTVGKIYAAM MIMEYYRQSK
1960 1970 1980 1990 2000
AKKLQAMREE QDRTPLMFQR MEPPSPTQEG GPGQNALPSA QLDPGGALMA
2010 2020 2030 2040 2050
HESGLKESPS WVTQRAQEMF QKTGTWSPER GPPTDMPNSQ PNSQSVEMRE
2060 2070 2080 2090 2100
MGRDGYSDSE HYLPMEGQGR AASMPRLPAE NQRRRGRPRG NNLSTISDTS
2110 2120 2130 2140 2150
PMKRSASVLG PKARRLDDYS LERVPPEENQ RHHQRRRDRS HRTSERSLGR
2160 2170 2180 2190 2200
YTDVDTGLGT DLSMTTQSGD LPSKERDQER GRPKDRKHRQ HHHHHHHHHP
2210 2220 2230 2240 2250
PPPDKDRYAQ ERPDHGRARA RDQRWSRSPS EGREHMVHRQ GSSSVSGSPA
2260 2270 2280 2290 2300
PSTSGTSTPR RGRRQLPQTP STPRPHVSYS PVIRKAGGSG PPQQQQQAVA
2310 2320 2330 2340 2350
RPGRAATSGP RRYPGPTAEP LAGDRPPTGG HSSGRSPRME RRVPGPARSE
2360 2370 2380 2390 2400
SPRACRHGGA RWPASGPHVS EGPPGPRHHG YYRGSDYDEA DGPGSGGGGE
2410 2420 2430 2440 2450
AMAGAYDPPP PARHASSGAT GRSPRTPRAS GPACASPSRH GRRLPNGYYP
2460 2470
AHGLARPRGP GSRKGLHEPY SESDDDWC
Length:2,478
Mass (Da):278,957
Last modified:November 30, 2016 - v2
Checksum:i3B4702B55859601E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JSUE03020853 Genomic DNA No translation available.
JSUE03020854 Genomic DNA No translation available.
JSUE03020855 Genomic DNA No translation available.
JSUE03020856 Genomic DNA No translation available.
JSUE03020857 Genomic DNA No translation available.
JSUE03020858 Genomic DNA No translation available.
JSUE03020859 Genomic DNA No translation available.
JSUE03020860 Genomic DNA No translation available.
JSUE03020861 Genomic DNA No translation available.
JSUE03020862 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMMUT00000005029; ENSMMUP00000004738; ENSMMUG00000003555

Similar proteinsi

Entry informationi

Entry nameiF7ETU0_MACMU
AccessioniPrimary (citable) accession number: F7ETU0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: November 30, 2016
Last modified: April 25, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health