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Protein
Submitted name:

Ubiquitin C

Gene

ubc

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Enzyme and pathway databases

ReactomeiR-XTR-110312. Translesion synthesis by REV1.
R-XTR-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-XTR-110320. Translesion Synthesis by POLH.
R-XTR-1169091. Activation of NF-kappaB in B cells.
R-XTR-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-XTR-1253288. Downregulation of ERBB4 signaling.
R-XTR-1295596. Spry regulation of FGF signaling.
R-XTR-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-XTR-168638. NOD1/2 Signaling Pathway.
R-XTR-174048. APC/C:Cdc20 mediated degradation of Cyclin B.
R-XTR-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-XTR-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-XTR-174154. APC/C:Cdc20 mediated degradation of Securin.
R-XTR-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-XTR-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-XTR-179409. APC-Cdc20 mediated degradation of Nek2A.
R-XTR-182971. EGFR downregulation.
R-XTR-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-XTR-195253. Degradation of beta-catenin by the destruction complex.
R-XTR-201681. TCF dependent signaling in response to WNT.
R-XTR-202424. Downstream TCR signaling.
R-XTR-209543. p75NTR recruits signalling complexes.
R-XTR-209560. NF-kB is activated and signals survival.
R-XTR-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-XTR-2173788. Downregulation of TGF-beta receptor signaling.
R-XTR-2173791. TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
R-XTR-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-XTR-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
R-XTR-2467813. Separation of Sister Chromatids.
R-XTR-2559580. Oxidative Stress Induced Senescence.
R-XTR-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-XTR-2559585. Oncogene Induced Senescence.
R-XTR-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-XTR-2672351. Stimuli-sensing channels.
R-XTR-2871837. FCERI mediated NF-kB activation.
R-XTR-3134975. Regulation of innate immune responses to cytosolic DNA.
R-XTR-3322077. Glycogen synthesis.
R-XTR-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-XTR-3769402. Deactivation of the beta-catenin transactivating complex.
R-XTR-382556. ABC-family proteins mediated transport.
R-XTR-445989. TAK1 activates NFkB by phosphorylation and activation of IKKs complex.
R-XTR-450302. activated TAK1 mediates p38 MAPK activation.
R-XTR-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
R-XTR-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-XTR-4641257. Degradation of AXIN.
R-XTR-4641258. Degradation of DVL.
R-XTR-4641263. Regulation of FZD by ubiquitination.
R-XTR-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.
R-XTR-5357905. Regulation of TNFR1 signaling.
R-XTR-5357956. TNFR1-induced NFkappaB signaling pathway.
R-XTR-5358346. Hedgehog ligand biogenesis.
R-XTR-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-XTR-5607764. CLEC7A (Dectin-1) signaling.
R-XTR-5610780. Degradation of GLI1 by the proteasome.
R-XTR-5610785. GLI3 is processed to GLI3R by the proteasome.
R-XTR-5632684. Hedgehog 'on' state.
R-XTR-5654726. Negative regulation of FGFR1 signaling.
R-XTR-5654727. Negative regulation of FGFR2 signaling.
R-XTR-5654732. Negative regulation of FGFR3 signaling.
R-XTR-5654733. Negative regulation of FGFR4 signaling.
R-XTR-5655862. Translesion synthesis by POLK.
R-XTR-5656121. Translesion synthesis by POLI.
R-XTR-5656169. Termination of translesion DNA synthesis.
R-XTR-5668541. TNFR2 non-canonical NF-kB pathway.
R-XTR-5675221. Negative regulation of MAPK pathway.
R-XTR-5675482. Regulation of necroptotic cell death.
R-XTR-5676590. NIK-->noncanonical NF-kB signaling.
R-XTR-5684264. MAP3K8 (TPL2)-dependent MAPK1/3 activation.
R-XTR-5685942. HDR through Homologous Recombination (HRR).
R-XTR-5687128. MAPK6/MAPK4 signaling.
R-XTR-5689603. UCH proteinases.
R-XTR-5689877. Josephin domain DUBs.
R-XTR-5689880. Ub-specific processing proteases.
R-XTR-5689896. Ovarian tumor domain proteases.
R-XTR-5689901. Metalloprotease DUBs.
R-XTR-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-XTR-5696394. DNA Damage Recognition in GG-NER.
R-XTR-5696395. Formation of Incision Complex in GG-NER.
R-XTR-5696397. Gap-filling DNA repair synthesis and ligation in GG-NER.
R-XTR-5696400. Dual Incision in GG-NER.
R-XTR-6781823. Formation of TC-NER Pre-Incision Complex.
R-XTR-6782135. Dual incision in TC-NER.
R-XTR-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-XTR-6783310. Fanconi Anemia Pathway.
R-XTR-6804756. Regulation of TP53 Activity through Phosphorylation.
R-XTR-6804757. Regulation of TP53 Degradation.
R-XTR-6804760. Regulation of TP53 Activity through Methylation.
R-XTR-6807004. Negative regulation of MET activity.
R-XTR-68827. CDT1 association with the CDC6:ORC:origin complex.
R-XTR-68949. Orc1 removal from chromatin.
R-XTR-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-XTR-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-XTR-69231. Cyclin D associated events in G1.
R-XTR-69298. Association of licensing factors with the pre-replicative complex.
R-XTR-69481. G2/M Checkpoints.
R-XTR-69541. Stabilization of p53.
R-XTR-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-XTR-8849469. PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.
R-XTR-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-XTR-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-XTR-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-XTR-8856828. Clathrin-mediated endocytosis.
R-XTR-8863795. Downregulation of ERBB2 signaling.
R-XTR-8866652. Synthesis of active ubiquitin: roles of E1 and E2 enzymes.
R-XTR-8866654. E3 ubiquitin ligases ubiquitinate target proteins.
R-XTR-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.
R-XTR-8939902. Regulation of RUNX2 expression and activity.
R-XTR-8941858. Regulation of RUNX3 expression and activity.
R-XTR-8948747. Regulation of PTEN localization.
R-XTR-8948751. Regulation of PTEN stability and activity.
R-XTR-8951664. Neddylation.
R-XTR-901032. ER Quality Control Compartment (ERQC).
R-XTR-9010553. Regulation of expression of SLITs and ROBOs.
R-XTR-9013507. NOTCH3 Activation and Transmission of Signal to the Nucleus.
R-XTR-9020702. Interleukin-1 signaling.
R-XTR-912631. Regulation of signaling by CBL.
R-XTR-917729. Endosomal Sorting Complex Required For Transport (ESCRT).
R-XTR-917937. Iron uptake and transport.
R-XTR-936440. Negative regulators of DDX58/IFIH1 signaling.
R-XTR-937039. IRAK1 recruits IKK complex.
R-XTR-937042. IRAK2 mediated activation of TAK1 complex.
R-XTR-975110. TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.
R-XTR-975144. IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation.
R-XTR-975163. IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
R-XTR-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Ubiquitin CImported
Gene namesi
Name:ubcImported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-6066017. ubc.

PTM / Processingi

Proteomic databases

PaxDbiF7DNS3.

Expressioni

Gene expression databases

BgeeiENSXETG00000017136.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 37Ubiquitin-likeInterPro annotationAdd BLAST37
Domaini38 – 112Ubiquitin-likeInterPro annotationAdd BLAST75
Domaini113 – 188Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini189 – 264Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini265 – 340Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini341 – 416Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini417 – 492Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini493 – 568Ubiquitin-likeInterPro annotationAdd BLAST76
Domaini569 – 644Ubiquitin-likeInterPro annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0001. Eukaryota.
COG5272. LUCA.
GeneTreeiENSGT00810000125435.
InParanoidiF7DNS3.
OMAiHLTMQIF.
OrthoDBiEOG091G178I.
TreeFamiTF354256.

Family and domain databases

InterProiView protein in InterPro
IPR019956. Ubiquitin.
IPR029071. Ubiquitin-like_domsf.
IPR019954. Ubiquitin_CS.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF00240. ubiquitin. 9 hits.
PRINTSiPR00348. UBIQUITIN.
SMARTiView protein in SMART
SM00213. UBQ. 8 hits.
SUPFAMiSSF54236. SSF54236. 9 hits.
PROSITEiView protein in PROSITE
PS00299. UBIQUITIN_1. 7 hits.
PS50053. UBIQUITIN_2. 9 hits.

Sequencei

Sequence statusi: Complete.

F7DNS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DQQRLIFAGK QLEDGTLSDY NIQKESTLHL VLRLRGGMQI FVKTLTGKTI
60 70 80 90 100
TLEVEPSDTI ENVKAKIQDK EGPPDQQRLI FAGKQLEDGR TLSDYNIQKE
110 120 130 140 150
STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA KIQDKEGIPP
160 170 180 190 200
DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
210 220 230 240 250
ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ
260 270 280 290 300
KESTLHLVLR LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI
310 320 330 340 350
PPDQQRLIFA GKQLEDGRTL SDYNIQKEST LHLVLRLREN MQIFVKTLTG
360 370 380 390 400
KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
410 420 430 440 450
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE
460 470 480 490 500
GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL
510 520 530 540 550
TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD
560 570 580 590 600
YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD
610 620 630 640
KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR LRGGV
Length:645
Mass (Da):72,703
Last modified:July 27, 2011 - v1
Checksum:iD235C7F2052D1FD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01185333 Genomic DNA. No translation available.
AAMC01185334 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSXETT00000037338; ENSXETP00000037338; ENSXETG00000017136.

Similar proteinsi

Entry informationi

Entry nameiF7DNS3_XENTR
AccessioniPrimary (citable) accession number: F7DNS3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported