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Protein
Submitted name:

Thrombomodulin

Gene

THBD

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
ThrombomodulinImported
Gene namesi
Name:THBDImported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei511 – 532HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500335602121 – 558Sequence analysisAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi441 ↔ 451PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMODG00000023139.

Interactioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000028571.

Structurei

3D structure databases

ProteinModelPortaliF7D9A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 160C-type lectinInterPro annotationAdd BLAST128
Domaini321 – 357EGF-likeInterPro annotationAdd BLAST37
Domaini361 – 401EGF-likeInterPro annotationAdd BLAST41
Domaini437 – 476EGF-likeInterPro annotationAdd BLAST40

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IF0T. Eukaryota.
ENOG410Y5JS. LUCA.
GeneTreeiENSGT00810000125382.
InParanoidiF7D9A3.
KOiK03907.
OrthoDBiEOG091G06M1.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link_sf.
IPR016187. CTDL_fold.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_cys_sf.
IPR015149. Tme5_EGF-like.
PfamiView protein in Pfam
PF07645. EGF_CA. 2 hits.
PF00059. Lectin_C. 1 hit.
PF09064. Tme5_EGF_like. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SUPFAMiSSF56436. SSF56436. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 2 hits.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 3 hits.
PS01187. EGF_CA. 2 hits.

Sequencei

Sequence statusi: Complete.

F7D9A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPFLLPLLS ILTMAELGLP ASPALQPGGS QCIEDDCYAV FWSPEQFTGA
60 70 80 90 100
NLVCQQFGGH LMTVRSSVAA DVISLLAQGG SEISLPASRL WIGLELEQNC
110 120 130 140 150
SHEQKGQLRG FRWVTGDTST SYSKWKHSGR GALCGHQCVV VSEDSASGSV
160 170 180 190 200
ELVWEEHSCD LVTEGFLCEY NYFGSCKPLN LEPSIGVNVT YSTPFGGKGA
210 220 230 240 250
DFQALPLNSH ALVVPLGLDL VCKKVEDTPR WSKESLGPWD CRVENGGCSQ
260 270 280 290 300
ICSQDNGNPE CLCSQGTLSK ADLRSCLTEG DLCNPGRCDQ YCQLSSEAPG
310 320 330 340 350
GYTCMCDSGY YLGEDGHSCI DVDDCALDPN PCPQKCVNTL GAFKCECNPG
360 370 380 390 400
FELLDSECVE LLDPCFGIQC QHKCLPLEGG AYRCICKEGF MPIPDQPDRC
410 420 430 440 450
MSFCNTSECP AICNPYNPDD CQCPDGYILD EDQMCSDIDD CAADECRGGE
460 470 480 490 500
CINLPGSFQC ICPPPYTLSR TGQECILIEI VSGDEGSGTI PSTEATGPTT
510 520 530 540 550
SSPVAGPIHS VVLIGIAVSI LSIITVLLAT ICHLRKKKYS AQATLDYKCA

GPTKEEVL
Length:558
Mass (Da):59,895
Last modified:July 27, 2011 - v1
Checksum:i1A89B5D81A3788FA
GO

Sequence databases

RefSeqiXP_007476681.1. XM_007476619.2.

Genome annotation databases

EnsembliENSMODT00000030155; ENSMODP00000028571; ENSMODG00000023139.
GeneIDi100033239.
KEGGimdo:100033239.

Similar proteinsi

Entry informationi

Entry nameiF7D9A3_MONDO
AccessioniPrimary (citable) accession number: F7D9A3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: January 31, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported