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UniProtKB - F7C376 (F7C376_MOUSE)

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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 145HelicalSequence analysisAdd BLAST18
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei268 – 290HelicalSequence analysisAdd BLAST23
Transmembranei349 – 370HelicalSequence analysisAdd BLAST22
Transmembranei382 – 404HelicalSequence analysisAdd BLAST23
Transmembranei550 – 567HelicalSequence analysisAdd BLAST18
Transmembranei587 – 610HelicalSequence analysisAdd BLAST24
Transmembranei679 – 698HelicalSequence analysisAdd BLAST20
Transmembranei751 – 778HelicalSequence analysisAdd BLAST28
Transmembranei921 – 943HelicalSequence analysisAdd BLAST23
Transmembranei963 – 984HelicalSequence analysisAdd BLAST22
Transmembranei996 – 1022HelicalSequence analysisAdd BLAST27
Transmembranei1042 – 1071HelicalSequence analysisAdd BLAST30
Transmembranei1167 – 1194HelicalSequence analysisAdd BLAST28
Transmembranei1245 – 1266HelicalSequence analysisAdd BLAST22
Transmembranei1272 – 1293HelicalSequence analysisAdd BLAST22
Transmembranei1442 – 1465HelicalSequence analysisAdd BLAST24
Transmembranei1535 – 1559HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiF7C376.
PaxDbiF7C376.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051331.
ExpressionAtlasiF7C376. baseline and differential.

Interactioni

GO - Molecular functioni

Complete GO annotation...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108413.

Structurei

3D structure databases

ProteinModelPortaliF7C376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1693 – 1727Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili781 – 807Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
OMAiPTTKINM.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Family and domain databases

InterProiView protein in InterPro
IPR031688. CAC1F_C.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
PANTHERiPTHR10037:SF240. PTHR10037:SF240. 1 hit.
PfamiView protein in Pfam
PF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiView protein in SMART
SM01062. Ca_chan_IQ. 1 hit.

Sequencei

Sequence statusi: Complete.

F7C376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL 
        60         70         80         90        100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP 
       110        120        130        140        150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 
       160        170        180        190        200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF 
       210        220        230        240        250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG 
       260        270        280        290        300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 
       310        320        330        340        350
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA 
       360        370        380        390        400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV 
       410        420        430        440        450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 
       460        470        480        490        500
NEDEGMDEDK PRNRGAPAGL HDQKKGKFAW FSHSTETHVS MPTSETESVN 
       510        520        530        540        550
TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR KCRAAVKSNV 
       560        570        580        590        600
FYWLVIFLVF LNTLTIASEH YNQPHWLTEV QDTANKALLA LFTAEMLLKM 
       610        620        630        640        650
YSLGLQAYFV SLFNRFDCFI VCGGILETIL VETKIMSPLG ISVLRCVRLL 
       660        670        680        690        700
RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG 
       710        720        730        740        750
KFNFDEMQTR RSTFDNFPQS LLTVFQILTG EDWNSVMYDG IMAYGGPSFP 
       760        770        780        790        800
GMLVCIYFII LFICGNYILL NVFLAIAVDN LADAESLTSA QKEEEEEKER 
       810        820        830        840        850
KKLARTASPE KKQEVMEKPA VEESKEEKIE LKSITADGES PPTTKINMDD 
       860        870        880        890        900
LQPSENEDKS PHSNPDTAGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP 
       910        920        930        940        950
EASAFFIFSP NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH 
       960        970        980        990       1000
TSFRNHILGN ADYVFTSIFT LEIILKMTAY GAFLHKGSFC RNYFNILDLL 
      1010       1020       1030       1040       1050
VVSVSLISFG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA 
      1060       1070       1080       1090       1100
IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL YTCSDSSKQT EAECKGNYIT 
      1110       1120       1130       1140       1150
YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE GWPELLYRSI 
      1160       1170       1180       1190       1200
DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ 
      1210       1220       1230       1240       1250
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM 
      1260       1270       1280       1290       1300
FVLILLNTIC LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP 
      1310       1320       1330       1340       1350
KHYFCDAWNT FDALIVVGSI VDIAITEVHP AEHTQCSPSM VRTTLQTTFP 
      1360       1370       1380       1390       1400
ASVAPPLATH VLSTLISRAL GTQPSSHCMW PPCPLCALTA CAHVSCARSA 
      1410       1420       1430       1440       1450
EENSRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI 
      1460       1470       1480       1490       1500
VMLFFIYAVI GMQVFGKIAL NDTTEINRNN NFQTFPQAVL LLFRCATGEA 
      1510       1520       1530       1540       1550
WQDIMLACMP GKKCAPESEP SNSTEGETPC GSSFAVFYFI SFYMLCAFLI 
      1560       1570       1580       1590       1600
INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWAEYDPE AKGRIKHLDV 
      1610       1620       1630       1640       1650
VTLLRRIQPP LGFGKLCPHR VACKRLVSMN MPLNSDGTVM FNATLFALVR 
      1660       1670       1680       1690       1700
TALRIKTEGN LEQANEELRA IIKKIWKRTS MKLLDQVVPP AGDDEVTVGK 
      1710       1720       1730       1740       1750
FYATFLIQEY FRKFKKRKEQ GLVGKPSQRN ALSLQAGLRT LHDIGPEIRR 
      1760       1770       1780       1790       1800
AISGDLTAEE ELDKAMKEAV SAASEDDIFR RAGGLFGNHV TYYQSDSRGN 
      1810       1820       1830       1840       1850
FPQTFATQRP LHINKTGNNQ ADTESPSHEK LVDSTFTPSS YSSTGSNANI 
      1860       1870       1880       1890       1900
NNANNTALGR FPHPAGYSST VSTVEGHGPP LSPAVRVQEA AWKLSSKRCH 
      1910       1920       1930       1940       1950
SRESQGATVN QEIFPDETRS VRMSEEAEYC SEPSLLSTDM FSYQEDEHRQ 
      1960       1970       1980       1990       2000
LTCPEEDKRE IQPSPKRSFL RSASLGRRAS FHLECLKRQK DQGGDISQKT 
      2010       2020       2030       2040       2050
ALPLHLVHHQ ALAVAGLSPL LQRSHSPTTF PRPCPTPPVT PGSRGRPLRP 
      2060       2070       2080       2090       2100
IPTLRLEGAE SSEKLNSSFP SIHCSSWSEE TTACSGSSSM ARRARPVSLT 
      2110       2120       2130       2140       2150
VPSQAGAPGR QFHGSASSLV EAVLISEGLG QFAQDPKFIE VTTQELADAC 
      2160       2170       2180       2190       2200
DMTIEEMENA ADNILSGGAQ QSPNGTLLPF VNCRDPGQDR AVAPEDESCA 
      2210       2220 
YALGRGRSEE ALADSRSYVS NL
Length:2,222
Mass (Da):248,894
Last modified:October 29, 2014 - v2
Checksum:iA2EF8A07BFDEA80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.
RefSeqiNP_001242931.1. NM_001256002.2.
UniGeneiMm.41628.
Mm.436656.

Genome annotation databases

EnsembliENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.
GeneIDi12288.
UCSCiuc012erj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.
RefSeqiNP_001242931.1. NM_001256002.2.
UniGeneiMm.41628.
Mm.436656.

3D structure databases

ProteinModelPortaliF7C376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108413.

Proteomic databases

MaxQBiF7C376.
PaxDbiF7C376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.
GeneIDi12288.
UCSCiuc012erj.3. mouse.

Organism-specific databases

CTDi775.
MGIiMGI:103013. Cacna1c.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
OMAiPTTKINM.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Miscellaneous databases

ChiTaRSiCacna1c. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051331.
ExpressionAtlasiF7C376. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR031688. CAC1F_C.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
PANTHERiPTHR10037:SF240. PTHR10037:SF240. 1 hit.
PfamiView protein in Pfam
PF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiView protein in SMART
SM01062. Ca_chan_IQ. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF7C376_MOUSE
AccessioniPrimary (citable) accession number: F7C376
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 29, 2014
Last modified: June 7, 2017
This is version 44 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.