F7C376 (F7C376_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1C Ensembl ENSMUSP00000108413

Gene names

Name:

Cacna1c Ensembl ENSMUSP00000108413 MGI 103013

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000108413

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2063 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification] RuleBase RU003808
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000108413

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS027359
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808 Ion channel Voltage-gated channel RuleBase RU003808 SAAS SAAS027359
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult walking behavior Inferred from genetic interaction PubMed 9882694. Source: MGI calcium ion import Inferred from Biological aspect of Ancestor. Source: RefGenome calcium ion transport Inferred from direct assay PubMed 7635187. Source: MGI calcium ion-dependent exocytosis Inferred from mutant phenotype PubMed 12881419. Source: MGI cellular calcium ion homeostasis Inferred from mutant phenotype PubMed 15132976. Source: MGI glucose homeostasis Inferred from mutant phenotype PubMed 12881419. Source: MGI growth hormone secretion Inferred from direct assay PubMed 1385406. Source: MGI insulin secretion Inferred from mutant phenotype PubMed 12881419. Source: MGI membrane depolarization during action potential Inferred from Biological aspect of Ancestor. Source: RefGenome positive regulation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Ensembl regulation of blood pressure Inferred from mutant phenotype PubMed 14609949. Source: MGI regulation of organ growth Inferred from mutant phenotype PubMed 15132976. Source: MGI regulation of vasoconstriction Inferred from mutant phenotype PubMed 14609949. Source: MGI smooth muscle contraction Inferred from mutant phenotype PubMed 16636102. Source: MGI smooth muscle contraction involved in micturition Inferred from mutant phenotype PubMed 15132976. Source: MGI synaptic transmission Inferred from mutant phenotype PubMed 16251435. Source: MGI visual learning Inferred from mutant phenotype PubMed 16251435. Source: MGI
Cellular_component	T-tubule Traceable author statement PubMed 11784029. Source: MGI Z disc Inferred from direct assay PubMed 19383796. Source: MGI caveolar macromolecular signaling complex Inferred from direct assay PubMed 16648270. Source: MGI dendritic shaft Inferred from direct assay PubMed 15090038. Source: MGI membrane Inferred from direct assay PubMed 15132976. Source: MGI neuronal cell body Inferred from direct assay PubMed 15090038. Source: MGI plasma membrane Inferred from direct assay PubMed 15090038PubMed 7598723. Source: MGI postsynaptic density Inferred from electronic annotation. Source: Ensembl voltage-gated calcium channel complex Traceable author statement PubMed 11296258. Source: MGI
Molecular_function	high voltage-gated calcium channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein binding Inferred from physical interaction PubMed 16787652. Source: MGI voltage-gated calcium channel activity Inferred from direct assay PubMed 1385406PubMed 16267232PubMed 7635187PubMed 7814415. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	F7C376 [UniParc]. Last modified October 3, 2012. Version 1. Checksum: E56D9F6387BE3EDA	FASTA	2,063	231,758
	10 20 30 40 50 60 ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS AILEQATKAD 70 80 90 100 110 120 GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN SIIKAMVPLL HIALLVLFVI 130 140 150 160 170 180 IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA EEDPSPCALE TGHGRQCQNG TVCKPGWDGP 190 200 210 220 230 240 KHGITNFDNF AFAMLTVFQC ITMEGWTDVL YWVNDAVGRD WPWIYFVTLI IIGSFFVLNL 250 260 270 280 290 300 VLGVLSGEFS KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 310 320 330 340 350 360 KPRNRGAPAG LHDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI EGENCGARLA 370 380 390 400 410 420 HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV FLNTLTIASE HYNQPHWLTE 430 440 450 460 470 480 VQDTANKALL ALFTAEMLLK MYSLGLQAYF VSLFNRFDCF IVCGGILETI LVETKIMSPL 490 500 510 520 530 540 GISVLRCVRL LRIFKITRYW NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG 550 560 570 580 590 600 GKFNFDEMQT RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI 610 620 630 640 650 660 ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP EKKQEVMEKP 670 680 690 700 710 720 AVEESKEEKI ELKSITADGE SPPTTKINMD DLQPSENEDK SPHSNPDTAG EEDEEEPEMP 730 740 750 760 770 780 VGPRPRPLSE LHLKEKAVPM PEASAFFIFS PNNRFRLQCH RIVNDTIFTN LILFFILLSS 790 800 810 820 830 840 ISLAAEDPVQ HTSFRNHILG NADYVFTSIF TLEIILKMTA YGAFLHKGSF CRNYFNILDL 850 860 870 880 890 900 LVVSVSLISF GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI 910 920 930 940 950 960 VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP IIQPRSWENS 970 980 990 1000 1010 1020 KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP IYNYRVEISI FFIIYIIIIA 1030 1040 1050 1060 1070 1080 FFMMNIFVGF VIVTFQEQGE QEYKNCELDK NQRQCVEYAL KARPLRRYIP KNQHQYKVWY 1090 1100 1110 1120 1130 1140 VVNSTYFEYL MFVLILLNTI CLAMQHYGQS CLFKIAMNIL NMLFTGLFTV EMILKLIAFK 1150 1160 1170 1180 1190 1200 PKHYFCDAWN TFDALIVVGS IVDIAITEVH PAEHTQCSPS MVRTTLQTTF PASVAPPLAT 1210 1220 1230 1240 1250 1260 HVLSTLISRA LGTQPSSHCM WPPCPLCALT ACAHVSCARS AEENSRISIT FFRLFRVMRL 1270 1280 1290 1300 1310 1320 VKLLSRGEGI RTLLWTFIKS FQALPYVALL IVMLFFIYAV IGMQVFGKIA LNDTTEINRN 1330 1340 1350 1360 1370 1380 NNFQTFPQAV LLLFRCATGE AWQDIMLACM PGKKCAPESE PSNSTEGETP CGSSFAVFYF 1390 1400 1410 1420 1430 1440 ISFYMLCAFL IINLFVAVIM DNFDYLTRDW SILGPHHLDE FKRIWAEYDP EAKGRIKHLD 1450 1460 1470 1480 1490 1500 VVTLLRRIQP PLGFGKLCPH RVACKRLVSM NMPLNSDGTV MFNATLFALV RTALRIKTEG 1510 1520 1530 1540 1550 1560 NLEQANEELR AIIKKIWKRT SMKLLDQVVP PAGDDEVTVG KFYATFLIQE YFRKFKKRKE 1570 1580 1590 1600 1610 1620 QGLVGKPSQR NALSLQAGLR TLHDIGPEIR RAISGDLTAE EELDKAMKEA VSAASEDDIF 1630 1640 1650 1660 1670 1680 RRAGGLFGNH VTYYQSDSRG NFPQTFATQR PLHINKTGNN QADTESPSHE KLVDSTFTPS 1690 1700 1710 1720 1730 1740 SYSSTGSNAN INNANNTALG RFPHPAGYSS TVSTVEGHGP PLSPAVRVQE AAWKLSSKRC 1750 1760 1770 1780 1790 1800 HSRESQGATV NQEIFPDETR SVRMSEEAEY CSEPSLLSTD MFSYQEDEHR QLTCPEEDKR 1810 1820 1830 1840 1850 1860 EIQPSPKRSF LRSASLGRRA SFHLECLKRQ KDQGGDISQK TALPLHLVHH QALAVAGLSP 1870 1880 1890 1900 1910 1920 LLQRSHSPTT FPRPCPTPPV TPGSRGRPLR PIPTLRLEGA ESSEKLNSSF PSIHCSSWSE 1930 1940 1950 1960 1970 1980 ETTACSGSSS MARRARPVSL TVPSQAGAPG RQFHGSASSL VEAVLISEGL GQFAQDPKFI 1990 2000 2010 2020 2030 2040 EVTTQELADA CDMTIEEMEN AADNILSGGA QQSPNGTLLP FVNCRDPGQD RAVAPEDESC 2050 2060 AYALGRGRSE EALADSRSYV SNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000108413.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000108413.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC036121 Genomic DNA. No translation available. AC127328 Genomic DNA. No translation available.
3D structure databases
ProteinModelPortal	F7C376.
SMR	F7C376. Positions 3-288, 385-674, 757-1031, 1087-1157, 1484-1564.
ModBase	Search...
MobiDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.
Organism-specific databases
MGI	MGI:103013. Cacna1c.
Phylogenomic databases
GeneTree	ENSGT00750000117620.
HOGENOM	HOG000231529.
OMA	NQHQYKV.
OrthoDB	EOG7T1RBQ.
TreeFam	TF312805.
Gene expression databases
ArrayExpress	F7C376.
Family and domain databases
Gene3D	1.20.120.350. 5 hits.
InterPro	IPR027359. Channel_four-helix_dom. IPR005821. Ion_trans_dom. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. [Graphical view]
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C.
SMART	SM01062. Ca_chan_IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CACNA1C. mouse.
NextBio	280766.
SOURCE	Search...

Entry information

Entry name

F7C376_MOUSE

Accession

Primary (citable) accession number: F7C376

Entry history

Integrated into UniProtKB/TrEMBL:	October 3, 2012
Last sequence update:	October 3, 2012
Last modified:	July 9, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)