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F7C376

- F7C376_MOUSE

UniProt

F7C376 - F7C376_MOUSE

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Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene
Cacna1c
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. high voltage-gated calcium channel activity Source: RefGenome
  2. protein binding Source: MGI
  3. voltage-gated calcium channel activity Source: MGI

GO - Biological processi

  1. adult walking behavior Source: MGI
  2. calcium ion-dependent exocytosis Source: MGI
  3. calcium ion import Source: RefGenome
  4. calcium ion transport Source: MGI
  5. cellular calcium ion homeostasis Source: MGI
  6. glucose homeostasis Source: MGI
  7. growth hormone secretion Source: MGI
  8. insulin secretion Source: MGI
  9. membrane depolarization during action potential Source: RefGenome
  10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  11. regulation of blood pressure Source: MGI
  12. regulation of organ growth Source: MGI
  13. regulation of vasoconstriction Source: MGI
  14. smooth muscle contraction Source: MGI
  15. smooth muscle contraction involved in micturition Source: MGI
  16. synaptic transmission Source: MGI
  17. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1CImported
Gene namesi
Name:Cacna1cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

GO - Cellular componenti

  1. caveolar macromolecular signaling complex Source: MGI
  2. dendritic shaft Source: MGI
  3. membrane Source: MGI
  4. neuronal cell body Source: MGI
  5. plasma membrane Source: MGI
  6. postsynaptic density Source: Ensembl
  7. T-tubule Source: MGI
  8. voltage-gated calcium channel complex Source: MGI
  9. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiF7C376.

Structurei

3D structure databases

ProteinModelPortaliF7C376.
SMRiF7C376. Positions 3-288, 385-674, 757-1031, 1087-1157, 1484-1564.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117620.
HOGENOMiHOG000231529.
OMAiNQHQYKV.
OrthoDBiEOG7T1RBQ.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7C376-1 [UniParc]FASTAAdd to Basket

« Hide

ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS     50
AILEQATKAD GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN 100
SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA 150
EEDPSPCALE TGHGRQCQNG TVCKPGWDGP KHGITNFDNF AFAMLTVFQC 200
ITMEGWTDVL YWVNDAVGRD WPWIYFVTLI IIGSFFVLNL VLGVLSGEFS 250
KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
KPRNRGAPAG LHDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI 350
EGENCGARLA HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV 400
FLNTLTIASE HYNQPHWLTE VQDTANKALL ALFTAEMLLK MYSLGLQAYF 450
VSLFNRFDCF IVCGGILETI LVETKIMSPL GISVLRCVRL LRIFKITRYW 500
NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG GKFNFDEMQT 550
RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI 600
ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP 650
EKKQEVMEKP AVEESKEEKI ELKSITADGE SPPTTKINMD DLQPSENEDK 700
SPHSNPDTAG EEDEEEPEMP VGPRPRPLSE LHLKEKAVPM PEASAFFIFS 750
PNNRFRLQCH RIVNDTIFTN LILFFILLSS ISLAAEDPVQ HTSFRNHILG 800
NADYVFTSIF TLEIILKMTA YGAFLHKGSF CRNYFNILDL LVVSVSLISF 850
GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI 900
VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP 950
IIQPRSWENS KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP 1000
IYNYRVEISI FFIIYIIIIA FFMMNIFVGF VIVTFQEQGE QEYKNCELDK 1050
NQRQCVEYAL KARPLRRYIP KNQHQYKVWY VVNSTYFEYL MFVLILLNTI 1100
CLAMQHYGQS CLFKIAMNIL NMLFTGLFTV EMILKLIAFK PKHYFCDAWN 1150
TFDALIVVGS IVDIAITEVH PAEHTQCSPS MVRTTLQTTF PASVAPPLAT 1200
HVLSTLISRA LGTQPSSHCM WPPCPLCALT ACAHVSCARS AEENSRISIT 1250
FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL IVMLFFIYAV 1300
IGMQVFGKIA LNDTTEINRN NNFQTFPQAV LLLFRCATGE AWQDIMLACM 1350
PGKKCAPESE PSNSTEGETP CGSSFAVFYF ISFYMLCAFL IINLFVAVIM 1400
DNFDYLTRDW SILGPHHLDE FKRIWAEYDP EAKGRIKHLD VVTLLRRIQP 1450
PLGFGKLCPH RVACKRLVSM NMPLNSDGTV MFNATLFALV RTALRIKTEG 1500
NLEQANEELR AIIKKIWKRT SMKLLDQVVP PAGDDEVTVG KFYATFLIQE 1550
YFRKFKKRKE QGLVGKPSQR NALSLQAGLR TLHDIGPEIR RAISGDLTAE 1600
EELDKAMKEA VSAASEDDIF RRAGGLFGNH VTYYQSDSRG NFPQTFATQR 1650
PLHINKTGNN QADTESPSHE KLVDSTFTPS SYSSTGSNAN INNANNTALG 1700
RFPHPAGYSS TVSTVEGHGP PLSPAVRVQE AAWKLSSKRC HSRESQGATV 1750
NQEIFPDETR SVRMSEEAEY CSEPSLLSTD MFSYQEDEHR QLTCPEEDKR 1800
EIQPSPKRSF LRSASLGRRA SFHLECLKRQ KDQGGDISQK TALPLHLVHH 1850
QALAVAGLSP LLQRSHSPTT FPRPCPTPPV TPGSRGRPLR PIPTLRLEGA 1900
ESSEKLNSSF PSIHCSSWSE ETTACSGSSS MARRARPVSL TVPSQAGAPG 1950
RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA CDMTIEEMEN 2000
AADNILSGGA QQSPNGTLLP FVNCRDPGQD RAVAPEDESC AYALGRGRSE 2050
EALADSRSYV SNL 2063
Length:2,063
Mass (Da):231,758
Last modified:October 3, 2012 - v1
Checksum:iE56D9F6387BE3EDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali F7C376.
SMRi F7C376. Positions 3-288, 385-674, 757-1031, 1087-1157, 1484-1564.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112793 ; ENSMUSP00000108413 ; ENSMUSG00000051331 .

Organism-specific databases

MGIi MGI:103013. Cacna1c.

Phylogenomic databases

GeneTreei ENSGT00750000117620.
HOGENOMi HOG000231529.
OMAi NQHQYKV.
OrthoDBi EOG7T1RBQ.
TreeFami TF312805.

Miscellaneous databases

ChiTaRSi CACNA1C. mouse.
NextBioi 280766.
SOURCEi Search...

Gene expression databases

ArrayExpressi F7C376.

Family and domain databases

Gene3Di 1.20.120.350. 5 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view ]
Pfami PF08763. Ca_chan_IQ. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view ]
PRINTSi PR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTi SM01062. Ca_chan_IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiF7C376_MOUSE
AccessioniPrimary (citable) accession number: F7C376
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: October 1, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

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