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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
Gene namesi
Name:Cacna1cImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:103013. Cacna1c.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei128 – 145HelicalSequence analysisAdd BLAST18
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei268 – 290HelicalSequence analysisAdd BLAST23
Transmembranei349 – 370HelicalSequence analysisAdd BLAST22
Transmembranei382 – 404HelicalSequence analysisAdd BLAST23
Transmembranei550 – 567HelicalSequence analysisAdd BLAST18
Transmembranei587 – 610HelicalSequence analysisAdd BLAST24
Transmembranei679 – 698HelicalSequence analysisAdd BLAST20
Transmembranei751 – 778HelicalSequence analysisAdd BLAST28
Transmembranei921 – 943HelicalSequence analysisAdd BLAST23
Transmembranei963 – 984HelicalSequence analysisAdd BLAST22
Transmembranei996 – 1022HelicalSequence analysisAdd BLAST27
Transmembranei1042 – 1071HelicalSequence analysisAdd BLAST30
Transmembranei1167 – 1194HelicalSequence analysisAdd BLAST28
Transmembranei1245 – 1266HelicalSequence analysisAdd BLAST22
Transmembranei1272 – 1293HelicalSequence analysisAdd BLAST22
Transmembranei1442 – 1465HelicalSequence analysisAdd BLAST24
Transmembranei1535 – 1559HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiF7C376.
PaxDbiF7C376.

Expressioni

Gene expression databases

BgeeiENSMUSG00000051331.
ExpressionAtlasiF7C376. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108413.

Structurei

3D structure databases

ProteinModelPortaliF7C376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1693 – 1727Ca_chan_IQInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili781 – 807Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
OMAiCYNQEGI.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 2 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

F7C376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEDK PRNRGAPAGL HDQKKGKFAW FSHSTETHVS MPTSETESVN
510 520 530 540 550
TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR KCRAAVKSNV
560 570 580 590 600
FYWLVIFLVF LNTLTIASEH YNQPHWLTEV QDTANKALLA LFTAEMLLKM
610 620 630 640 650
YSLGLQAYFV SLFNRFDCFI VCGGILETIL VETKIMSPLG ISVLRCVRLL
660 670 680 690 700
RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG
710 720 730 740 750
KFNFDEMQTR RSTFDNFPQS LLTVFQILTG EDWNSVMYDG IMAYGGPSFP
760 770 780 790 800
GMLVCIYFII LFICGNYILL NVFLAIAVDN LADAESLTSA QKEEEEEKER
810 820 830 840 850
KKLARTASPE KKQEVMEKPA VEESKEEKIE LKSITADGES PPTTKINMDD
860 870 880 890 900
LQPSENEDKS PHSNPDTAGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP
910 920 930 940 950
EASAFFIFSP NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH
960 970 980 990 1000
TSFRNHILGN ADYVFTSIFT LEIILKMTAY GAFLHKGSFC RNYFNILDLL
1010 1020 1030 1040 1050
VVSVSLISFG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA
1060 1070 1080 1090 1100
IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL YTCSDSSKQT EAECKGNYIT
1110 1120 1130 1140 1150
YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE GWPELLYRSI
1160 1170 1180 1190 1200
DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ
1210 1220 1230 1240 1250
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM
1260 1270 1280 1290 1300
FVLILLNTIC LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP
1310 1320 1330 1340 1350
KHYFCDAWNT FDALIVVGSI VDIAITEVHP AEHTQCSPSM VRTTLQTTFP
1360 1370 1380 1390 1400
ASVAPPLATH VLSTLISRAL GTQPSSHCMW PPCPLCALTA CAHVSCARSA
1410 1420 1430 1440 1450
EENSRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI
1460 1470 1480 1490 1500
VMLFFIYAVI GMQVFGKIAL NDTTEINRNN NFQTFPQAVL LLFRCATGEA
1510 1520 1530 1540 1550
WQDIMLACMP GKKCAPESEP SNSTEGETPC GSSFAVFYFI SFYMLCAFLI
1560 1570 1580 1590 1600
INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWAEYDPE AKGRIKHLDV
1610 1620 1630 1640 1650
VTLLRRIQPP LGFGKLCPHR VACKRLVSMN MPLNSDGTVM FNATLFALVR
1660 1670 1680 1690 1700
TALRIKTEGN LEQANEELRA IIKKIWKRTS MKLLDQVVPP AGDDEVTVGK
1710 1720 1730 1740 1750
FYATFLIQEY FRKFKKRKEQ GLVGKPSQRN ALSLQAGLRT LHDIGPEIRR
1760 1770 1780 1790 1800
AISGDLTAEE ELDKAMKEAV SAASEDDIFR RAGGLFGNHV TYYQSDSRGN
1810 1820 1830 1840 1850
FPQTFATQRP LHINKTGNNQ ADTESPSHEK LVDSTFTPSS YSSTGSNANI
1860 1870 1880 1890 1900
NNANNTALGR FPHPAGYSST VSTVEGHGPP LSPAVRVQEA AWKLSSKRCH
1910 1920 1930 1940 1950
SRESQGATVN QEIFPDETRS VRMSEEAEYC SEPSLLSTDM FSYQEDEHRQ
1960 1970 1980 1990 2000
LTCPEEDKRE IQPSPKRSFL RSASLGRRAS FHLECLKRQK DQGGDISQKT
2010 2020 2030 2040 2050
ALPLHLVHHQ ALAVAGLSPL LQRSHSPTTF PRPCPTPPVT PGSRGRPLRP
2060 2070 2080 2090 2100
IPTLRLEGAE SSEKLNSSFP SIHCSSWSEE TTACSGSSSM ARRARPVSLT
2110 2120 2130 2140 2150
VPSQAGAPGR QFHGSASSLV EAVLISEGLG QFAQDPKFIE VTTQELADAC
2160 2170 2180 2190 2200
DMTIEEMENA ADNILSGGAQ QSPNGTLLPF VNCRDPGQDR AVAPEDESCA
2210 2220
YALGRGRSEE ALADSRSYVS NL
Length:2,222
Mass (Da):248,894
Last modified:October 29, 2014 - v2
Checksum:iA2EF8A07BFDEA80E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.
RefSeqiNP_001242931.1. NM_001256002.2.
UniGeneiMm.41628.
Mm.436656.

Genome annotation databases

EnsembliENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.
GeneIDi12288.
UCSCiuc012erj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC036121 Genomic DNA. No translation available.
AC115816 Genomic DNA. No translation available.
AC126453 Genomic DNA. No translation available.
AC127328 Genomic DNA. No translation available.
AC163353 Genomic DNA. No translation available.
RefSeqiNP_001242931.1. NM_001256002.2.
UniGeneiMm.41628.
Mm.436656.

3D structure databases

ProteinModelPortaliF7C376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108413.

Proteomic databases

MaxQBiF7C376.
PaxDbiF7C376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.
GeneIDi12288.
UCSCiuc012erj.3. mouse.

Organism-specific databases

CTDi775.
MGIiMGI:103013. Cacna1c.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
OMAiCYNQEGI.
OrthoDBiEOG091G0TKO.
TreeFamiTF312805.

Miscellaneous databases

ChiTaRSiCacna1c. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051331.
ExpressionAtlasiF7C376. baseline and differential.

Family and domain databases

Gene3Di1.20.120.350. 5 hits.
InterProiIPR031688. CAC1F_C.
IPR027359. Channel_four-helix_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 2 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16885. CAC1F_C. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF7C376_MOUSE
AccessioniPrimary (citable) accession number: F7C376
Entry historyi
Integrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 29, 2014
Last modified: November 2, 2016
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.