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F7C376

- F7C376_MOUSE

UniProt

F7C376 - F7C376_MOUSE

Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1C

Gene

Cacna1c

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 19 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. high voltage-gated calcium channel activity Source: RefGenome
    2. protein binding Source: MGI
    3. voltage-gated calcium channel activity Source: MGI

    GO - Biological processi

    1. adult walking behavior Source: MGI
    2. calcium ion-dependent exocytosis Source: MGI
    3. calcium ion import Source: RefGenome
    4. calcium ion transport Source: MGI
    5. cellular calcium ion homeostasis Source: MGI
    6. glucose homeostasis Source: MGI
    7. growth hormone secretion Source: MGI
    8. insulin secretion Source: MGI
    9. membrane depolarization during action potential Source: RefGenome
    10. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    11. regulation of blood pressure Source: MGI
    12. regulation of organ growth Source: MGI
    13. regulation of vasoconstriction Source: MGI
    14. smooth muscle contraction Source: MGI
    15. smooth muscle contraction involved in micturition Source: MGI
    16. synaptic transmission Source: MGI
    17. visual learning Source: MGI

    Keywords - Molecular functioni

    Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Voltage-dependent L-type calcium channel subunit alpha-1CImported
    Gene namesi
    Name:Cacna1cImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:103013. Cacna1c.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. caveolar macromolecular signaling complex Source: MGI
    2. dendritic shaft Source: MGI
    3. membrane Source: MGI
    4. neuronal cell body Source: MGI
    5. plasma membrane Source: MGI
    6. postsynaptic density Source: Ensembl
    7. T-tubule Source: MGI
    8. voltage-gated calcium channel complex Source: MGI
    9. Z disc Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiF7C376.

    Structurei

    3D structure databases

    ProteinModelPortaliF7C376.
    SMRiF7C376. Positions 3-288, 385-674, 757-1031, 1087-1157, 1484-1564.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117620.
    HOGENOMiHOG000231529.
    OMAiNQHQYKV.
    OrthoDBiEOG7T1RBQ.
    TreeFamiTF312805.

    Family and domain databases

    Gene3Di1.20.120.350. 5 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005451. VDCC_L_a1csu.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view]
    PfamiPF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view]
    PRINTSiPR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01635. LVDCCALPHA1C.
    SMARTiSM01062. Ca_chan_IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    F7C376-1 [UniParc]FASTAAdd to Basket

    « Hide

    ERVEYLFLII FTVEAFLKVI AYGLLFHPNA YLRNGWNLLD FIIVVVGLFS     50
    AILEQATKAD GANALGGKGA GFDVKALRAF RVLRPLRLVS GVPSLQVVLN 100
    SIIKAMVPLL HIALLVLFVI IIYAIIGLEL FMGKMHKTCY NQEGIIDVPA 150
    EEDPSPCALE TGHGRQCQNG TVCKPGWDGP KHGITNFDNF AFAMLTVFQC 200
    ITMEGWTDVL YWVNDAVGRD WPWIYFVTLI IIGSFFVLNL VLGVLSGEFS 250
    KEREKAKARG DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEDEGMDED 300
    KPRNRGAPAG LHDQKKGKFA WFSHSTETHV SMPTSETESV NTENVAGGDI 350
    EGENCGARLA HRISKSKFSR YWRRWNRFCR RKCRAAVKSN VFYWLVIFLV 400
    FLNTLTIASE HYNQPHWLTE VQDTANKALL ALFTAEMLLK MYSLGLQAYF 450
    VSLFNRFDCF IVCGGILETI LVETKIMSPL GISVLRCVRL LRIFKITRYW 500
    NSLSNLVASL LNSVRSIASL LLLLFLFIII FSLLGMQLFG GKFNFDEMQT 550
    RRSTFDNFPQ SLLTVFQILT GEDWNSVMYD GIMAYGGPSF PGMLVCIYFI 600
    ILFICGNYIL LNVFLAIAVD NLADAESLTS AQKEEEEEKE RKKLARTASP 650
    EKKQEVMEKP AVEESKEEKI ELKSITADGE SPPTTKINMD DLQPSENEDK 700
    SPHSNPDTAG EEDEEEPEMP VGPRPRPLSE LHLKEKAVPM PEASAFFIFS 750
    PNNRFRLQCH RIVNDTIFTN LILFFILLSS ISLAAEDPVQ HTSFRNHILG 800
    NADYVFTSIF TLEIILKMTA YGAFLHKGSF CRNYFNILDL LVVSVSLISF 850
    GIQSSAINVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIVI 900
    VTTLLQFMFA CIGVQLFKGK LYTCSDSSKQ TEAECKGNYI TYKDGEVDHP 950
    IIQPRSWENS KFDFDNVLAA MMALFTVSTF EGWPELLYRS IDSHTEDKGP 1000
    IYNYRVEISI FFIIYIIIIA FFMMNIFVGF VIVTFQEQGE QEYKNCELDK 1050
    NQRQCVEYAL KARPLRRYIP KNQHQYKVWY VVNSTYFEYL MFVLILLNTI 1100
    CLAMQHYGQS CLFKIAMNIL NMLFTGLFTV EMILKLIAFK PKHYFCDAWN 1150
    TFDALIVVGS IVDIAITEVH PAEHTQCSPS MVRTTLQTTF PASVAPPLAT 1200
    HVLSTLISRA LGTQPSSHCM WPPCPLCALT ACAHVSCARS AEENSRISIT 1250
    FFRLFRVMRL VKLLSRGEGI RTLLWTFIKS FQALPYVALL IVMLFFIYAV 1300
    IGMQVFGKIA LNDTTEINRN NNFQTFPQAV LLLFRCATGE AWQDIMLACM 1350
    PGKKCAPESE PSNSTEGETP CGSSFAVFYF ISFYMLCAFL IINLFVAVIM 1400
    DNFDYLTRDW SILGPHHLDE FKRIWAEYDP EAKGRIKHLD VVTLLRRIQP 1450
    PLGFGKLCPH RVACKRLVSM NMPLNSDGTV MFNATLFALV RTALRIKTEG 1500
    NLEQANEELR AIIKKIWKRT SMKLLDQVVP PAGDDEVTVG KFYATFLIQE 1550
    YFRKFKKRKE QGLVGKPSQR NALSLQAGLR TLHDIGPEIR RAISGDLTAE 1600
    EELDKAMKEA VSAASEDDIF RRAGGLFGNH VTYYQSDSRG NFPQTFATQR 1650
    PLHINKTGNN QADTESPSHE KLVDSTFTPS SYSSTGSNAN INNANNTALG 1700
    RFPHPAGYSS TVSTVEGHGP PLSPAVRVQE AAWKLSSKRC HSRESQGATV 1750
    NQEIFPDETR SVRMSEEAEY CSEPSLLSTD MFSYQEDEHR QLTCPEEDKR 1800
    EIQPSPKRSF LRSASLGRRA SFHLECLKRQ KDQGGDISQK TALPLHLVHH 1850
    QALAVAGLSP LLQRSHSPTT FPRPCPTPPV TPGSRGRPLR PIPTLRLEGA 1900
    ESSEKLNSSF PSIHCSSWSE ETTACSGSSS MARRARPVSL TVPSQAGAPG 1950
    RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA CDMTIEEMEN 2000
    AADNILSGGA QQSPNGTLLP FVNCRDPGQD RAVAPEDESC AYALGRGRSE 2050
    EALADSRSYV SNL 2063
    Length:2,063
    Mass (Da):231,758
    Last modified:October 3, 2012 - v1
    Checksum:iE56D9F6387BE3EDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC036121 Genomic DNA. No translation available.
    AC115816 Genomic DNA. No translation available.
    AC126453 Genomic DNA. No translation available.
    AC127328 Genomic DNA. No translation available.
    AC163353 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC036121 Genomic DNA. No translation available.
    AC115816 Genomic DNA. No translation available.
    AC126453 Genomic DNA. No translation available.
    AC127328 Genomic DNA. No translation available.
    AC163353 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali F7C376.
    SMRi F7C376. Positions 3-288, 385-674, 757-1031, 1087-1157, 1484-1564.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112793 ; ENSMUSP00000108413 ; ENSMUSG00000051331 .

    Organism-specific databases

    MGIi MGI:103013. Cacna1c.

    Phylogenomic databases

    GeneTreei ENSGT00750000117620.
    HOGENOMi HOG000231529.
    OMAi NQHQYKV.
    OrthoDBi EOG7T1RBQ.
    TreeFami TF312805.

    Miscellaneous databases

    ChiTaRSi CACNA1C. mouse.
    NextBioi 280766.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi F7C376.

    Family and domain databases

    Gene3Di 1.20.120.350. 5 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR014873. VDCC_a1su_IQ.
    IPR005451. VDCC_L_a1csu.
    IPR005446. VDCC_L_a1su.
    IPR002077. VDCCAlpha1.
    [Graphical view ]
    Pfami PF08763. Ca_chan_IQ. 1 hit.
    PF00520. Ion_trans. 4 hits.
    [Graphical view ]
    PRINTSi PR00167. CACHANNEL.
    PR01630. LVDCCALPHA1.
    PR01635. LVDCCALPHA1C.
    SMARTi SM01062. Ca_chan_IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiF7C376_MOUSE
    AccessioniPrimary (citable) accession number: F7C376
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 19 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3