UniProtKB - F7C376 (F7C376_MOUSE)
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Protein
Voltage-dependent L-type calcium channel subunit alpha
Gene
Cacna1c
Organism
Mus musculus (Mouse)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.UniRule annotation
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- calmodulin binding Source: Ensembl
- high voltage-gated calcium channel activity Source: Ensembl
- voltage-gated calcium channel activity involved in AV node cell action potential Source: Ensembl
GO - Biological processi
- calcium ion transmembrane transport via high voltage-gated calcium channel Source: Ensembl
- camera-type eye development Source: Ensembl
- embryonic forelimb morphogenesis Source: Ensembl
- heart development Source: Ensembl
- immune system development Source: Ensembl
- membrane depolarization during atrial cardiac muscle cell action potential Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: Ensembl
- regulation of heart rate by cardiac conduction Source: Ensembl
- regulation of ion transmembrane transport Source: UniProtKB-KW
- regulation of ventricular cardiac muscle cell action potential Source: Ensembl
Keywordsi
Molecular function | Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:Cacna1cImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103013. Cacna1c. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 128 – 145 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 215 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 290 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 349 – 370 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 382 – 404 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 550 – 567 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 587 – 610 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 679 – 698 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 751 – 778 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 921 – 943 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 963 – 984 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 996 – 1022 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 1042 – 1071 | HelicalSequence analysisAdd BLAST | 30 | |
Transmembranei | 1167 – 1194 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 1245 – 1266 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1272 – 1293 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1442 – 1465 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1535 – 1559 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSMUSG00000051331. |
ExpressionAtlasi | F7C376. baseline and differential. |
Interactioni
GO - Molecular functioni
- alpha-actinin binding Source: Ensembl
- calmodulin binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000108413. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1693 – 1727 | Ca_chan_IQInterPro annotationAdd BLAST | 35 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 781 – 807 | Sequence analysisAdd BLAST | 27 | |
Coiled coili | 1654 – 1674 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG2301. Eukaryota. ENOG410XNP6. LUCA. |
GeneTreei | ENSGT00830000128247. |
OMAi | PTTKINM. |
OrthoDBi | EOG091G0TKO. |
TreeFami | TF312805. |
Family and domain databases
Gene3Di | 1.20.120.350. 4 hits. |
InterProi | View protein in InterPro IPR031688. CAC1F_C. IPR031649. GPHH_dom. IPR005821. Ion_trans_dom. IPR014873. VDCC_a1su_IQ. IPR005451. VDCC_L_a1csu. IPR005446. VDCC_L_a1su. IPR002077. VDCCAlpha1. IPR027359. Volt_channel_dom_sf. |
Pfami | View protein in Pfam PF08763. Ca_chan_IQ. 1 hit. PF16885. CAC1F_C. 1 hit. PF16905. GPHH. 1 hit. PF00520. Ion_trans. 4 hits. |
PRINTSi | PR00167. CACHANNEL. PR01630. LVDCCALPHA1. PR01635. LVDCCALPHA1C. |
SMARTi | View protein in SMART SM01062. Ca_chan_IQ. 1 hit. |
i Sequence
Sequence statusi: Complete.
F7C376-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVNENTRMYV PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGGTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIIDVPAE EDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEDK PRNRGAPAGL HDQKKGKFAW FSHSTETHVS MPTSETESVN
510 520 530 540 550
TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR KCRAAVKSNV
560 570 580 590 600
FYWLVIFLVF LNTLTIASEH YNQPHWLTEV QDTANKALLA LFTAEMLLKM
610 620 630 640 650
YSLGLQAYFV SLFNRFDCFI VCGGILETIL VETKIMSPLG ISVLRCVRLL
660 670 680 690 700
RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG
710 720 730 740 750
KFNFDEMQTR RSTFDNFPQS LLTVFQILTG EDWNSVMYDG IMAYGGPSFP
760 770 780 790 800
GMLVCIYFII LFICGNYILL NVFLAIAVDN LADAESLTSA QKEEEEEKER
810 820 830 840 850
KKLARTASPE KKQEVMEKPA VEESKEEKIE LKSITADGES PPTTKINMDD
860 870 880 890 900
LQPSENEDKS PHSNPDTAGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP
910 920 930 940 950
EASAFFIFSP NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH
960 970 980 990 1000
TSFRNHILGN ADYVFTSIFT LEIILKMTAY GAFLHKGSFC RNYFNILDLL
1010 1020 1030 1040 1050
VVSVSLISFG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA
1060 1070 1080 1090 1100
IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL YTCSDSSKQT EAECKGNYIT
1110 1120 1130 1140 1150
YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE GWPELLYRSI
1160 1170 1180 1190 1200
DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ
1210 1220 1230 1240 1250
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM
1260 1270 1280 1290 1300
FVLILLNTIC LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP
1310 1320 1330 1340 1350
KHYFCDAWNT FDALIVVGSI VDIAITEVHP AEHTQCSPSM VRTTLQTTFP
1360 1370 1380 1390 1400
ASVAPPLATH VLSTLISRAL GTQPSSHCMW PPCPLCALTA CAHVSCARSA
1410 1420 1430 1440 1450
EENSRISITF FRLFRVMRLV KLLSRGEGIR TLLWTFIKSF QALPYVALLI
1460 1470 1480 1490 1500
VMLFFIYAVI GMQVFGKIAL NDTTEINRNN NFQTFPQAVL LLFRCATGEA
1510 1520 1530 1540 1550
WQDIMLACMP GKKCAPESEP SNSTEGETPC GSSFAVFYFI SFYMLCAFLI
1560 1570 1580 1590 1600
INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWAEYDPE AKGRIKHLDV
1610 1620 1630 1640 1650
VTLLRRIQPP LGFGKLCPHR VACKRLVSMN MPLNSDGTVM FNATLFALVR
1660 1670 1680 1690 1700
TALRIKTEGN LEQANEELRA IIKKIWKRTS MKLLDQVVPP AGDDEVTVGK
1710 1720 1730 1740 1750
FYATFLIQEY FRKFKKRKEQ GLVGKPSQRN ALSLQAGLRT LHDIGPEIRR
1760 1770 1780 1790 1800
AISGDLTAEE ELDKAMKEAV SAASEDDIFR RAGGLFGNHV TYYQSDSRGN
1810 1820 1830 1840 1850
FPQTFATQRP LHINKTGNNQ ADTESPSHEK LVDSTFTPSS YSSTGSNANI
1860 1870 1880 1890 1900
NNANNTALGR FPHPAGYSST VSTVEGHGPP LSPAVRVQEA AWKLSSKRCH
1910 1920 1930 1940 1950
SRESQGATVN QEIFPDETRS VRMSEEAEYC SEPSLLSTDM FSYQEDEHRQ
1960 1970 1980 1990 2000
LTCPEEDKRE IQPSPKRSFL RSASLGRRAS FHLECLKRQK DQGGDISQKT
2010 2020 2030 2040 2050
ALPLHLVHHQ ALAVAGLSPL LQRSHSPTTF PRPCPTPPVT PGSRGRPLRP
2060 2070 2080 2090 2100
IPTLRLEGAE SSEKLNSSFP SIHCSSWSEE TTACSGSSSM ARRARPVSLT
2110 2120 2130 2140 2150
VPSQAGAPGR QFHGSASSLV EAVLISEGLG QFAQDPKFIE VTTQELADAC
2160 2170 2180 2190 2200
DMTIEEMENA ADNILSGGAQ QSPNGTLLPF VNCRDPGQDR AVAPEDESCA
2210 2220
YALGRGRSEE ALADSRSYVS NL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC036121 Genomic DNA. No translation available. AC115816 Genomic DNA. No translation available. AC126453 Genomic DNA. No translation available. AC127328 Genomic DNA. No translation available. AC163353 Genomic DNA. No translation available. |
RefSeqi | NP_001242931.1. NM_001256002.2. |
UniGenei | Mm.41628. Mm.436656. |
Genome annotation databases
Ensembli | ENSMUST00000112793; ENSMUSP00000108413; ENSMUSG00000051331. |
GeneIDi | 12288. |
UCSCi | uc012erj.3. mouse. |
Similar proteinsi
Entry informationi
Entry namei | F7C376_MOUSE | |
Accessioni | F7C376Primary (citable) accession number: F7C376 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 29, 2014 | |
Last modified: | March 28, 2018 | |
This is version 50 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |